| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 10, 2000 | W | Detroit Lions | Washington Redskins | 15 | 10 | box | |
| 2 | Sun | September 17, 2000 | L | Detroit Lions | Tampa Bay Buccaneers | 10 | 31 | box | |
| 3 | Sun | September 24, 2000 | W | Detroit Lions | @ | Chicago Bears | 21 | 14 | box |
| 4 | Sun | October 1, 2000 | L | Detroit Lions | Minnesota Vikings | 24 | 31 | box | |
| 5 | Sun | October 8, 2000 | W | Detroit Lions | Green Bay Packers | 31 | 24 | box | |
| 6 | Thu | October 19, 2000 | W | Detroit Lions | @ | Tampa Bay Buccaneers | 28 | 14 | box |
| 7 | Sun | October 29, 2000 | L | Detroit Lions | @ | Indianapolis Colts | 18 | 30 | box |
| 8 | Sun | November 5, 2000 | L | Detroit Lions | Miami Dolphins | 8 | 23 | box | |
| 9 | Sun | November 12, 2000 | W | Detroit Lions | Atlanta Falcons | 13 | 10 | box | |
| 10 | Sun | November 19, 2000 | W | Detroit Lions | @ | New York Giants | 31 | 21 | box |
| 11 | Thu | November 23, 2000 | W | Detroit Lions | New England Patriots | 34 | 9 | box | |
| 12 | Thu | November 30, 2000 | L | Detroit Lions | @ | Minnesota Vikings | 17 | 24 | box |
| 13 | Sun | December 10, 2000 | L | Detroit Lions | @ | Green Bay Packers | 13 | 26 | box |
| 14 | Sun | December 17, 2000 | W | Detroit Lions | @ | New York Jets | 10 | 7 | box |
| 15 | Sun | December 24, 2000 | L | Detroit Lions | Chicago Bears | 20 | 23 | box |