| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 7, 1980 | W | Detroit Lions | @ | Los Angeles Rams | 41 | 20 | box |
| 2 | Sun | September 14, 1980 | W | Detroit Lions | @ | Green Bay Packers | 29 | 7 | box |
| 3 | Sun | September 21, 1980 | W | Detroit Lions | St. Louis Cardinals | 20 | 7 | box | |
| 4 | Sun | September 28, 1980 | W | Detroit Lions | Minnesota Vikings | 27 | 7 | box | |
| 5 | Sun | October 5, 1980 | L | Detroit Lions | @ | Atlanta Falcons | 28 | 43 | box |
| 6 | Sun | October 12, 1980 | W | Detroit Lions | New Orleans Saints | 24 | 13 | box | |
| 7 | Sun | October 19, 1980 | L | Detroit Lions | @ | Chicago Bears | 7 | 24 | box |
| 8 | Sun | October 26, 1980 | L | Detroit Lions | @ | Kansas City Chiefs | 17 | 20 | box |
| 9 | Sun | November 2, 1980 | W | Detroit Lions | San Francisco 49ers | 17 | 13 | box | |
| 10 | Sun | November 9, 1980 | L | Detroit Lions | @ | Minnesota Vikings | 0 | 34 | box |
| 11 | Sun | November 16, 1980 | L | Detroit Lions | Baltimore Colts | 9 | 10 | box | |
| 12 | Sun | November 23, 1980 | W | Detroit Lions | @ | Tampa Bay Buccaneers | 24 | 10 | box |
| 13 | Thu | November 27, 1980 | L | Detroit Lions | Chicago Bears | 17 | 23 | box | |
| 14 | Sun | December 7, 1980 | L | Detroit Lions | @ | St. Louis Cardinals | 23 | 24 | box |
| 15 | Sun | December 14, 1980 | W | Detroit Lions | Tampa Bay Buccaneers | 27 | 14 | box | |
| 16 | Sun | December 21, 1980 | W | Detroit Lions | Green Bay Packers | 24 | 3 | box |