| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 12, 1999 | L | Buffalo Bills | @ | Indianapolis Colts | 14 | 31 | box |
| 2 | Sun | September 19, 1999 | W | Buffalo Bills | New York Jets | 17 | 3 | box | |
| 3 | Sun | September 26, 1999 | W | Buffalo Bills | Philadelphia Eagles | 26 | 0 | box | |
| 4 | Mon | October 4, 1999 | W | Buffalo Bills | @ | Miami Dolphins | 23 | 18 | box |
| 5 | Sun | October 10, 1999 | W | Buffalo Bills | Pittsburgh Steelers | 24 | 21 | box | |
| 6 | Sun | October 17, 1999 | L | Buffalo Bills | Oakland Raiders | 14 | 20 | box | |
| 7 | Sun | October 24, 1999 | L | Buffalo Bills | @ | Seattle Seahawks | 16 | 26 | box |
| 8 | Sun | October 31, 1999 | W | Buffalo Bills | @ | Baltimore Ravens | 13 | 10 | box |
| 9 | Sun | November 7, 1999 | W | Buffalo Bills | @ | Washington Redskins | 34 | 17 | box |
| 10 | Sun | November 14, 1999 | W | Buffalo Bills | Miami Dolphins | 23 | 3 | box | |
| 11 | Sun | November 21, 1999 | L | Buffalo Bills | @ | New York Jets | 7 | 17 | box |
| 12 | Sun | November 28, 1999 | W | Buffalo Bills | New England Patriots | 17 | 7 | box | |
| 13 | Sun | December 12, 1999 | L | Buffalo Bills | New York Giants | 17 | 19 | box | |
| 14 | Sun | December 19, 1999 | W | Buffalo Bills | @ | Arizona Cardinals | 31 | 21 | box |
| 15 | Sun | December 26, 1999 | W | Buffalo Bills | @ | New England Patriots | 13 | 10 | box |