| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 7, 1980 | W | Baltimore Colts | @ | New York Jets | 17 | 14 | box |
| 2 | Sun | September 14, 1980 | L | Baltimore Colts | Pittsburgh Steelers | 17 | 20 | box | |
| 3 | Sun | September 21, 1980 | L | Baltimore Colts | @ | Houston Oilers | 16 | 21 | box |
| 4 | Sun | September 28, 1980 | W | Baltimore Colts | New York Jets | 35 | 21 | box | |
| 5 | Sun | October 5, 1980 | W | Baltimore Colts | @ | Miami Dolphins | 30 | 17 | box |
| 6 | Sun | October 12, 1980 | W | Baltimore Colts | @ | Buffalo Bills | 17 | 12 | box |
| 7 | Sun | October 19, 1980 | L | Baltimore Colts | New England Patriots | 21 | 37 | box | |
| 8 | Sun | October 26, 1980 | L | Baltimore Colts | St. Louis Cardinals | 10 | 17 | box | |
| 9 | Sun | November 2, 1980 | W | Baltimore Colts | @ | Kansas City Chiefs | 31 | 24 | box |
| 10 | Sun | November 9, 1980 | L | Baltimore Colts | Cleveland Browns | 27 | 28 | box | |
| 11 | Sun | November 16, 1980 | W | Baltimore Colts | @ | Detroit Lions | 10 | 9 | box |
| 12 | Sun | November 23, 1980 | L | Baltimore Colts | @ | New England Patriots | 21 | 47 | box |
| 13 | Sun | December 7, 1980 | L | Baltimore Colts | @ | Cincinnati Bengals | 33 | 34 | box |
| 14 | Sun | December 14, 1980 | L | Baltimore Colts | Miami Dolphins | 14 | 24 | box | |
| 15 | Sun | December 21, 1980 | L | Baltimore Colts | Kansas City Chiefs | 28 | 38 | box |