| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 6, 1981 | W | Baltimore Colts | @ | New England Patriots | 29 | 28 | box |
| 2 | Sun | September 13, 1981 | L | Baltimore Colts | Buffalo Bills | 3 | 35 | box | |
| 3 | Sun | September 20, 1981 | L | Baltimore Colts | @ | Denver Broncos | 10 | 28 | box |
| 4 | Sun | September 27, 1981 | L | Baltimore Colts | Miami Dolphins | 28 | 31 | box | |
| 5 | Sun | October 4, 1981 | L | Baltimore Colts | @ | Buffalo Bills | 17 | 23 | box |
| 6 | Sun | October 11, 1981 | L | Baltimore Colts | Cincinnati Bengals | 19 | 41 | box | |
| 7 | Sun | October 18, 1981 | L | Baltimore Colts | San Diego Chargers | 14 | 43 | box | |
| 8 | Sun | October 25, 1981 | L | Baltimore Colts | @ | Cleveland Browns | 28 | 42 | box |
| 9 | Sun | November 1, 1981 | L | Baltimore Colts | @ | Miami Dolphins | 10 | 27 | box |
| 10 | Sun | November 8, 1981 | L | Baltimore Colts | New York Jets | 14 | 41 | box | |
| 11 | Sun | November 15, 1981 | L | Baltimore Colts | @ | Philadelphia Eagles | 13 | 38 | box |
| 12 | Sun | November 22, 1981 | L | Baltimore Colts | St. Louis Cardinals | 24 | 35 | box | |
| 13 | Sun | November 29, 1981 | L | Baltimore Colts | @ | New York Jets | 0 | 25 | box |
| 14 | Sun | December 13, 1981 | L | Baltimore Colts | @ | Washington Redskins | 14 | 38 | box |
| 15 | Sun | December 20, 1981 | W | Baltimore Colts | New England Patriots | 23 | 21 | box |