| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 7, 1986 | L | Buffalo Bills | New York Jets | 24 | 28 | box | |
| 2 | Sun | September 14, 1986 | L | Buffalo Bills | @ | Cincinnati Bengals | 33 | 36 | box |
| 3 | Sun | September 21, 1986 | W | Buffalo Bills | St. Louis Cardinals | 17 | 10 | box | |
| 4 | Sun | September 28, 1986 | L | Buffalo Bills | Kansas City Chiefs | 17 | 20 | box | |
| 5 | Sun | October 5, 1986 | L | Buffalo Bills | @ | New York Jets | 13 | 14 | box |
| 6 | Sun | October 12, 1986 | L | Buffalo Bills | @ | Miami Dolphins | 14 | 27 | box |
| 7 | Sun | October 19, 1986 | W | Buffalo Bills | Indianapolis Colts | 24 | 13 | box | |
| 8 | Sun | October 26, 1986 | L | Buffalo Bills | New England Patriots | 3 | 23 | box | |
| 9 | Sun | November 2, 1986 | L | Buffalo Bills | @ | Tampa Bay Buccaneers | 28 | 34 | box |
| 10 | Sun | November 9, 1986 | W | Buffalo Bills | Pittsburgh Steelers | 16 | 12 | box | |
| 11 | Sun | November 16, 1986 | L | Buffalo Bills | Miami Dolphins | 24 | 34 | box | |
| 12 | Sun | November 23, 1986 | L | Buffalo Bills | @ | New England Patriots | 19 | 22 | box |
| 13 | Sun | November 30, 1986 | W | Buffalo Bills | @ | Kansas City Chiefs | 17 | 14 | box |
| 14 | Sun | December 7, 1986 | L | Buffalo Bills | Cleveland Browns | 17 | 21 | box | |
| 15 | Sun | December 14, 1986 | L | Buffalo Bills | @ | Indianapolis Colts | 14 | 24 | box |
| 16 | Sun | December 21, 1986 | L | Buffalo Bills | @ | Houston Oilers | 7 | 16 | box |