| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 1, 1991 | W | Buffalo Bills | Miami Dolphins | 35 | 31 | box | |
| 2 | Sun | September 8, 1991 | W | Buffalo Bills | Pittsburgh Steelers | 52 | 34 | box | |
| 3 | Sun | September 15, 1991 | W | Buffalo Bills | @ | New York Jets | 23 | 20 | box |
| 4 | Sun | September 22, 1991 | W | Buffalo Bills | @ | Tampa Bay Buccaneers | 17 | 10 | box |
| 5 | Sun | September 29, 1991 | W | Buffalo Bills | Chicago Bears | 35 | 20 | box | |
| 6 | Mon | October 7, 1991 | L | Buffalo Bills | @ | Kansas City Chiefs | 6 | 33 | box |
| 7 | Sun | October 13, 1991 | W | Buffalo Bills | Indianapolis Colts | 42 | 6 | box | |
| 8 | Mon | October 21, 1991 | W | Buffalo Bills | Cincinnati Bengals | 35 | 16 | box | |
| 9 | Sun | November 3, 1991 | W | Buffalo Bills | New England Patriots | 22 | 17 | box | |
| 10 | Sun | November 10, 1991 | W | Buffalo Bills | @ | Green Bay Packers | 34 | 24 | box |
| 11 | Mon | November 18, 1991 | W | Buffalo Bills | @ | Miami Dolphins | 41 | 27 | box |
| 12 | Sun | November 24, 1991 | L | Buffalo Bills | @ | New England Patriots | 13 | 16 | box |
| 13 | Sun | December 1, 1991 | W | Buffalo Bills | New York Jets | 24 | 13 | box | |
| 14 | Sun | December 8, 1991 | W | Buffalo Bills | @ | Los Angeles Raiders | 30 | 27 | box |
| 15 | Sun | December 15, 1991 | W | Buffalo Bills | @ | Indianapolis Colts | 35 | 7 | box |
| 16 | Sun | January 5, 1992 | W | Buffalo Bills | Kansas City Chiefs | 37 | 14 | box | |
| 17 | Sun | January 12, 1992 | W | Buffalo Bills | Denver Broncos | 10 | 7 | box | |
| 18 | Sun | January 26, 1992 | L | Buffalo Bills | N | Washington Redskins | 24 | 37 | box |