| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 6, 1992 | W | Buffalo Bills | Los Angeles Rams | 40 | 7 | box | |
| 2 | Sun | September 13, 1992 | W | Buffalo Bills | @ | San Francisco 49ers | 34 | 31 | box |
| 3 | Sun | September 20, 1992 | W | Buffalo Bills | Indianapolis Colts | 38 | 0 | box | |
| 4 | Sun | September 27, 1992 | W | Buffalo Bills | @ | New England Patriots | 41 | 7 | box |
| 5 | Sun | October 4, 1992 | L | Buffalo Bills | Miami Dolphins | 10 | 37 | box | |
| 6 | Sun | October 11, 1992 | L | Buffalo Bills | @ | Los Angeles Raiders | 3 | 20 | box |
| 7 | Mon | October 26, 1992 | W | Buffalo Bills | @ | New York Jets | 24 | 20 | box |
| 8 | Sun | November 1, 1992 | W | Buffalo Bills | New England Patriots | 16 | 7 | box | |
| 9 | Sun | November 8, 1992 | W | Buffalo Bills | Pittsburgh Steelers | 28 | 20 | box | |
| 10 | Mon | November 16, 1992 | W | Buffalo Bills | @ | Miami Dolphins | 26 | 20 | box |
| 11 | Sun | November 22, 1992 | W | Buffalo Bills | Atlanta Falcons | 41 | 14 | box | |
| 12 | Sun | November 29, 1992 | L | Buffalo Bills | @ | Indianapolis Colts | 13 | 16 | box |
| 13 | Sun | December 6, 1992 | L | Buffalo Bills | New York Jets | 17 | 24 | box | |
| 14 | Sat | December 12, 1992 | W | Buffalo Bills | Denver Broncos | 27 | 17 | box | |
| 15 | Sun | December 20, 1992 | W | Buffalo Bills | @ | New Orleans Saints | 20 | 16 | box |
| 16 | Sun | December 27, 1992 | L | Buffalo Bills | @ | Houston Oilers | 3 | 27 | box |
| 17 | Sun | January 17, 1993 | W | Buffalo Bills | @ | Miami Dolphins | 29 | 10 | box |
| 18 | Sun | January 31, 1993 | L | Buffalo Bills | N | Dallas Cowboys | 17 | 52 | box |