| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 7, 1980 | W | Minnesota Vikings | Atlanta Falcons | 24 | 23 | box | |
| 2 | Sun | September 14, 1980 | L | Minnesota Vikings | Philadelphia Eagles | 7 | 42 | box | |
| 3 | Sun | September 21, 1980 | W | Minnesota Vikings | @ | Chicago Bears | 34 | 14 | box |
| 4 | Sun | September 28, 1980 | L | Minnesota Vikings | @ | Detroit Lions | 7 | 27 | box |
| 5 | Sun | October 5, 1980 | L | Minnesota Vikings | Pittsburgh Steelers | 17 | 23 | box | |
| 6 | Sun | October 12, 1980 | W | Minnesota Vikings | Chicago Bears | 13 | 7 | box | |
| 7 | Sun | October 19, 1980 | L | Minnesota Vikings | @ | Cincinnati Bengals | 0 | 14 | box |
| 8 | Sun | October 26, 1980 | L | Minnesota Vikings | @ | Green Bay Packers | 3 | 16 | box |
| 9 | Sun | November 9, 1980 | W | Minnesota Vikings | Detroit Lions | 34 | 0 | box | |
| 10 | Sun | November 16, 1980 | W | Minnesota Vikings | Tampa Bay Buccaneers | 38 | 30 | box | |
| 11 | Sun | November 23, 1980 | L | Minnesota Vikings | Green Bay Packers | 13 | 25 | box | |
| 12 | Sun | November 30, 1980 | W | Minnesota Vikings | @ | New Orleans Saints | 23 | 20 | box |
| 13 | Sun | December 7, 1980 | W | Minnesota Vikings | @ | Tampa Bay Buccaneers | 21 | 10 | box |
| 14 | Sun | December 14, 1980 | W | Minnesota Vikings | Cleveland Browns | 28 | 23 | box | |
| 15 | Sun | December 21, 1980 | L | Minnesota Vikings | @ | Houston Oilers | 16 | 20 | box |
| 16 | Sat | January 3, 1981 | L | Minnesota Vikings | @ | Philadelphia Eagles | 16 | 31 | box |