| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 9, 1990 | L | Houston Oilers | @ | Atlanta Falcons | 27 | 47 | box |
| 2 | Sun | September 16, 1990 | L | Houston Oilers | @ | Pittsburgh Steelers | 9 | 20 | box |
| 3 | Sun | September 23, 1990 | W | Houston Oilers | Indianapolis Colts | 24 | 10 | box | |
| 4 | Sun | September 30, 1990 | W | Houston Oilers | @ | San Diego Chargers | 17 | 7 | box |
| 5 | Sun | October 7, 1990 | L | Houston Oilers | San Francisco 49ers | 21 | 24 | box | |
| 6 | Sun | October 14, 1990 | W | Houston Oilers | Cincinnati Bengals | 48 | 17 | box | |
| 7 | Sun | October 21, 1990 | W | Houston Oilers | New Orleans Saints | 23 | 10 | box | |
| 8 | Sun | October 28, 1990 | L | Houston Oilers | New York Jets | 12 | 17 | box | |
| 9 | Sun | November 4, 1990 | L | Houston Oilers | @ | Los Angeles Rams | 13 | 17 | box |
| 10 | Sun | November 18, 1990 | W | Houston Oilers | @ | Cleveland Browns | 35 | 23 | box |
| 11 | Mon | November 26, 1990 | W | Houston Oilers | Buffalo Bills | 27 | 24 | box | |
| 12 | Sun | December 2, 1990 | L | Houston Oilers | @ | Seattle Seahawks | 10 | 13 | box |
| 13 | Sun | December 9, 1990 | W | Houston Oilers | Cleveland Browns | 58 | 14 | box | |
| 14 | Sun | December 16, 1990 | W | Houston Oilers | @ | Kansas City Chiefs | 27 | 10 | box |
| 15 | Sun | December 23, 1990 | L | Houston Oilers | @ | Cincinnati Bengals | 20 | 40 | box |