| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 1, 1991 | W | Houston Oilers | Los Angeles Raiders | 47 | 17 | box | |
| 2 | Sun | September 8, 1991 | W | Houston Oilers | @ | Cincinnati Bengals | 30 | 7 | box |
| 3 | Mon | September 16, 1991 | W | Houston Oilers | Kansas City Chiefs | 17 | 7 | box | |
| 4 | Sun | September 22, 1991 | L | Houston Oilers | @ | New England Patriots | 20 | 24 | box |
| 5 | Sun | October 6, 1991 | W | Houston Oilers | Denver Broncos | 42 | 14 | box | |
| 6 | Sun | October 13, 1991 | W | Houston Oilers | @ | New York Jets | 23 | 20 | box |
| 7 | Sun | October 20, 1991 | W | Houston Oilers | @ | Miami Dolphins | 17 | 13 | box |
| 8 | Sun | October 27, 1991 | W | Houston Oilers | Cincinnati Bengals | 35 | 3 | box | |
| 9 | Sun | November 3, 1991 | L | Houston Oilers | @ | Washington Redskins | 13 | 16 | box |
| 10 | Sun | November 10, 1991 | W | Houston Oilers | Dallas Cowboys | 26 | 23 | box | |
| 11 | Sun | November 17, 1991 | W | Houston Oilers | Cleveland Browns | 28 | 24 | box | |
| 12 | Sun | November 24, 1991 | L | Houston Oilers | @ | Pittsburgh Steelers | 14 | 26 | box |
| 13 | Mon | December 2, 1991 | L | Houston Oilers | Philadelphia Eagles | 6 | 13 | box | |
| 14 | Sun | December 8, 1991 | W | Houston Oilers | Pittsburgh Steelers | 31 | 6 | box | |
| 15 | Sun | December 15, 1991 | W | Houston Oilers | @ | Cleveland Browns | 17 | 14 | box |
| 16 | Sat | December 21, 1991 | L | Houston Oilers | @ | New York Giants | 20 | 24 | box |
| 17 | Sun | December 29, 1991 | W | Houston Oilers | New York Jets | 17 | 10 | box | |
| 18 | Sat | January 4, 1992 | L | Houston Oilers | @ | Denver Broncos | 24 | 26 | box |