| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | October 1, 2000 | W | Pittsburgh Steelers | @ | Jacksonville Jaguars | 24 | 13 | box |
| 2 | Sun | October 8, 2000 | W | Pittsburgh Steelers | @ | New York Jets | 20 | 3 | box |
| 3 | Sun | October 29, 2000 | W | Pittsburgh Steelers | @ | Baltimore Ravens | 9 | 6 | box |
| 4 | Sun | November 5, 2000 | L | Pittsburgh Steelers | @ | Tennessee Titans | 7 | 9 | box |
| 5 | Sun | November 12, 2000 | L | Pittsburgh Steelers | Philadelphia Eagles | 23 | 26 | box | |
| 6 | Sun | November 19, 2000 | L | Pittsburgh Steelers | Jacksonville Jaguars | 24 | 34 | box | |
| 7 | Sun | November 26, 2000 | W | Pittsburgh Steelers | @ | Cincinnati Bengals | 48 | 28 | box |
| 8 | Sun | December 3, 2000 | W | Pittsburgh Steelers | Oakland Raiders | 21 | 20 | box | |
| 9 | Sun | December 10, 2000 | L | Pittsburgh Steelers | @ | New York Giants | 10 | 30 | box |
| 10 | Sat | December 16, 2000 | W | Pittsburgh Steelers | Washington Redskins | 24 | 3 | box | |
| 11 | Sun | December 24, 2000 | W | Pittsburgh Steelers | @ | San Diego Chargers | 34 | 21 | box |