| Rank | Player (age), + - HOFer, Bold - Active | Y/G | Year | Teams |
|---|---|---|---|---|
| 1. | Keith Lincoln (24) | 206.0 | 1963 | SDG |
| 2. | Priest Holmes (30) | 176.0 | 2003 | KAN |
| 3. | Cedric Benson (27) | 169.0 | 2009 | CIN |
| Barry Sanders+ (25) | 169.0 | 1993 | DET | |
| 5. | Paul Lowe (24) | 165.0 | 1960 | LAC |
| 6. | Earnest Byner (23) | 161.0 | 1985 | CLE |
| 7. | Eric Dickerson+ (26) | 158.0 | 1986 | RAM |
| 8. | Terrell Davis (26) | 156.0 | 1998 | DEN |
| 9. | Marcus Allen+ (23) | 155.3 | 1983 | RAI |
| 10. | John Riggins+ (33) | 152.5 | 1982 | WAS |
| 11. | Eric Dickerson+ (25) | 147.0 | 1985 | RAM |
| 12. | Terrell Davis (25) | 145.3 | 1997 | DEN |
| 13. | Arian Foster (25) | 142.5 | 2011 | HOU |
| 14. | Tiki Barber (31) | 137.0 | 2006 | NYG |
| 15. | Franco Harris+ (26) | 132.0 | 1976 | PIT |
| 16. | Thurman Thomas+ (24) | 130.0 | 1990 | BUF |
| 17. | Marion Barber (24) | 129.0 | 2007 | DAL |
| 18. | Brian Westbrook (27) | 128.5 | 2006 | PHI |
| 19. | Fred Taylor (22) | 124.0 | 1998 | JAX |
| 20. | LaDainian Tomlinson (27) | 123.0 | 2006 | SDG |
| 21. | Fred Taylor (23) | 122.5 | 1999 | JAX |
| 22. | Cookie Gilchrist (29) | 122.0 | 1964 | BUF |
| 23. | Marcus Allen+ (25) | 121.0 | 1985 | RAI |
| Isaac Redman (27) | 121.0 | 2011 | PIT | |
| 25. | Ottis Anderson (32) | 120.0 | 1989 | NYG |