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Output includes all games from 1960 to 2009.
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Sk | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2007 | 8 | 2007-11-04 | 23-284 | SFO | @ | ATL | L 16-20 | 0.5 |
| 2 | 2007 | 9 | 2007-11-12 | 23-292 | SFO | @ | SEA | L 0-24 | 1.0 |
| 3 | 2007 | 10 | 2007-11-18 | 23-298 | SFO | STL | L 9-13 | 0.5 | |
| 4 | 2007 | 11 | 2007-11-25 | 23-305 | SFO | @ | ARI | W 37-31 | 0.5 |
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Sk | |
| 5 | 2008 | 1 | 2008-09-07 | 24-227 | SFO | ARI | L 13-23 | 2.0 | |
| 6 | 2008 | 2 | 2008-09-14 | 24-234 | SFO | @ | SEA | W 33-30 | 0.0 |
| 7 | 2008 | 3 | 2008-09-21 | 24-241 | SFO | DET | W 31-13 | 1.0 | |
| 8 | 2008 | 5 | 2008-10-05 | 24-255 | SFO | NWE | L 21-30 | 0.5 | |
| 9 | 2008 | 6 | 2008-10-12 | 24-262 | SFO | PHI | L 26-40 | 0.0 | |
| 10 | 2008 | 7 | 2008-10-19 | 24-269 | SFO | @ | NYG | L 17-29 | 0.0 |
| 11 | 2008 | 8 | 2008-10-26 | 24-276 | SFO | SEA | L 13-34 | 0.0 | |
| 12 | 2008 | 9 | 2008-11-10 | 24-291 | SFO | @ | ARI | L 24-29 | 0.0 |
| 13 | 2008 | 10 | 2008-11-16 | 24-297 | SFO | STL | W 35-16 | 1.0 | |
| 14 | 2008 | 12 | 2008-11-30 | 24-311 | SFO | @ | BUF | W 10-3 | 1.0 |
| 15 | 2008 | 13 | 2008-12-07 | 24-318 | SFO | NYJ | W 24-14 | 1.5 | |
| 16 | 2008 | 14 | 2008-12-14 | 24-325 | SFO | @ | MIA | L 9-14 | 0.0 |
| 17 | 2008 | 15 | 2008-12-21 | 24-332 | SFO | @ | STL | W 17-16 | 1.0 |
| 18 | 2008 | 16 | 2008-12-28 | 24-339 | SFO | WAS | W 27-24 | 0.0 | |
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Sk | |
| 19 | 2009 | 1 | 2009-09-13 | 25-232 | SFO | @ | ARI | W 20-16 | 1.0 |
| 20 | 2009 | 2 | 2009-09-20 | 25-239 | SFO | SEA | W 23-10 | 0.0 | |
| 21 | 2009 | 3 | 2009-09-27 | 25-246 | SFO | @ | MIN | L 24-27 | 0.0 |
| 22 | 2009 | 4 | 2009-10-04 | 25-253 | SFO | STL | W 35-0 | 0.0 | |
| 23 | 2009 | 5 | 2009-10-11 | 25-260 | SFO | ATL | L 10-45 | 0.0 | |
| 24 | 2009 | 6 | 2009-10-25 | 25-274 | SFO | @ | HOU | L 21-24 | 0.0 |
| 25 | 2009 | 7 | 2009-11-01 | 25-281 | SFO | @ | IND | L 14-18 | 0.0 |
| 26 | 2009 | 8 | 2009-11-08 | 25-288 | SFO | TEN | L 27-34 | 0.0 | |
| 27 | 2009 | 9 | 2009-11-12 | 25-292 | SFO | CHI | W 10-6 | 0.0 | |
| 28 | 2009 | 10 | 2009-11-22 | 25-302 | SFO | @ | GNB | L 24-30 | 1.0 |
| 28 Games | 12.5 | ||||||||