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Output includes all games from 1960 to 2009.
| Rk | Year | G# | Date | Age | Tm | Opp | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 2005 | 1 | 2005-09-11 | 28-332 | SFO | STL | W 28-25 | |
| 2 | 2005 | 2 | 2005-09-18 | 28-339 | SFO | @ | PHI | L 3-42 |
| 3 | 2005 | 3 | 2005-09-25 | 28-346 | SFO | DAL | L 31-34 | |
| 4 | 2005 | 4 | 2005-10-02 | 28-353 | SFO | @ | ARI | L 14-31 |
| 5 | 2005 | 5 | 2005-10-09 | 28-360 | SFO | IND | L 3-28 | |
| 6 | 2005 | 6 | 2005-10-23 | 29-009 | SFO | @ | WAS | L 17-52 |
| 7 | 2005 | 7 | 2005-10-30 | 29-016 | SFO | TAM | W 15-10 | |
| 8 | 2005 | 8 | 2005-11-06 | 29-023 | SFO | NYG | L 6-24 | |
| 9 | 2005 | 9 | 2005-11-13 | 29-030 | SFO | @ | CHI | L 9-17 |
| 10 | 2005 | 10 | 2005-11-20 | 29-037 | SFO | SEA | L 25-27 | |
| 11 | 2005 | 11 | 2005-11-27 | 29-044 | SFO | @ | TEN | L 22-33 |
| 12 | 2005 | 12 | 2005-12-04 | 29-051 | SFO | ARI | L 10-17 | |
| 13 | 2005 | 13 | 2005-12-11 | 29-058 | SFO | @ | SEA | L 3-41 |
| 14 | 2005 | 14 | 2005-12-18 | 29-065 | SFO | @ | JAX | L 9-10 |
| 15 | 2005 | 15 | 2005-12-24 | 29-071 | SFO | @ | STL | W 24-20 |
| 16 | 2005 | 16 | 2006-01-01 | 29-079 | SFO | HOU | W 20-17 | |
| Rk | Year | G# | Date | Age | Tm | Opp | Result | |
| 17 | 2006 | 1 | 2006-09-10 | 29-331 | SFO | @ | ARI | L 27-34 |
| 18 | 2006 | 2 | 2006-09-17 | 29-338 | SFO | STL | W 20-13 | |
| 19 | 2006 | 3 | 2006-09-24 | 29-345 | SFO | PHI | L 24-38 | |
| 20 | 2006 | 4 | 2006-10-01 | 29-352 | SFO | @ | KAN | L 0-41 |
| 21 | 2006 | 5 | 2006-10-08 | 29-359 | SFO | OAK | W 34-20 | |
| 22 | 2006 | 6 | 2006-10-15 | 30-001 | SFO | SDG | L 19-48 | |
| 23 | 2006 | 7 | 2006-10-29 | 30-015 | SFO | @ | CHI | L 10-41 |
| 24 | 2006 | 8 | 2006-11-05 | 30-022 | SFO | MIN | W 9-3 | |
| 25 | 2006 | 9 | 2006-11-12 | 30-029 | SFO | @ | DET | W 19-13 |
| 26 | 2006 | 10 | 2006-11-19 | 30-036 | SFO | SEA | W 20-14 | |
| 27 | 2006 | 11 | 2006-11-26 | 30-043 | SFO | @ | STL | L 17-20 |
| 28 | 2006 | 12 | 2006-12-03 | 30-050 | SFO | @ | NOR | L 10-34 |
| 29 | 2006 | 13 | 2006-12-10 | 30-057 | SFO | GNB | L 19-30 | |
| 30 | 2006 | 14 | 2006-12-14 | 30-061 | SFO | @ | SEA | W 24-14 |
| 31 | 2006 | 15 | 2006-12-24 | 30-071 | SFO | ARI | L 20-26 | |
| 32 | 2006 | 16 | 2006-12-31 | 30-078 | SFO | @ | DEN | W 26-23 |
| Rk | Year | G# | Date | Age | Tm | Opp | Result | |
| 33 | 2007 | 1 | 2007-09-10 | 30-331 | SFO | ARI | W 20-17 | |
| 34 | 2007 | 2 | 2007-09-16 | 30-337 | SFO | @ | STL | W 17-16 |
| 35 | 2007 | 3 | 2007-09-23 | 30-344 | SFO | @ | PIT | L 16-37 |
| 36 | 2007 | 4 | 2007-09-30 | 30-351 | SFO | SEA | L 3-23 | |
| 37 | 2007 | 5 | 2007-10-07 | 30-358 | SFO | BAL | L 7-9 | |
| 38 | 2007 | 6 | 2007-10-21 | 31-007 | SFO | @ | NYG | L 15-33 |
| 39 | 2007 | 7 | 2007-10-28 | 31-014 | SFO | NOR | L 10-31 | |
| 40 | 2007 | 8 | 2007-11-04 | 31-021 | SFO | @ | ATL | L 16-20 |
| 41 | 2007 | 9 | 2007-11-12 | 31-029 | SFO | @ | SEA | L 0-24 |
| 42 | 2007 | 10 | 2007-11-18 | 31-035 | SFO | STL | L 9-13 | |
| 43 | 2007 | 11 | 2007-11-25 | 31-042 | SFO | @ | ARI | W 37-31 |
| 44 | 2007 | 12 | 2007-12-02 | 31-049 | SFO | @ | CAR | L 14-31 |
| 45 | 2007 | 13 | 2007-12-09 | 31-056 | SFO | MIN | L 7-27 | |
| 46 | 2007 | 14 | 2007-12-15 | 31-062 | SFO | CIN | W 20-13 | |
| 47 | 2007 | 15 | 2007-12-23 | 31-070 | SFO | TAM | W 21-19 | |
| 48 | 2007 | 16 | 2007-12-30 | 31-077 | SFO | @ | CLE | L 7-20 |
| Rk | Year | G# | Date | Age | Tm | Opp | Result | |
| 49 | 2008 | 5 | 2008-10-05 | 31-357 | SFO | NWE | L 21-30 | |
| 50 | 2008 | 8 | 2008-10-26 | 32-012 | SFO | SEA | L 13-34 | |
| 51 | 2008 | 13 | 2008-12-07 | 32-054 | SFO | NYJ | W 24-14 | |
| 52 | 2008 | 14 | 2008-12-14 | 32-061 | SFO | @ | MIA | L 9-14 |
| Rk | Year | G# | Date | Age | Tm | Opp | Result | |
| 53 | 2009 | 1 | 2009-09-13 | 32-334 | SFO | @ | ARI | W 20-16 |
| 54 | 2009 | 2 | 2009-09-20 | 32-341 | SFO | SEA | W 23-10 | |
| 55 | 2009 | 4 | 2009-10-04 | 32-355 | SFO | STL | W 35-0 | |
| 56 | 2009 | 7 | 2009-11-01 | 33-018 | SFO | @ | IND | L 14-18 |
| 56 Games | ||||||||