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Output includes all games that meet at least one of the following criteria: 300+ yards passing, 100+ yards rushing, 100+ yards receiving, or 4+ passing touchdowns.
| Passing | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Cmp | Att | Yds | TD | Int | |||||
| 1 | 1998 | 1 | 1998-09-06 | 22-166 | IND | MIA | L 15-24 | 21 | 37 | 56.8% | 302 | 1 | 3 | 58.6 | 8.16 | 5.05 | |
| 2 | 1998 | 4 | 1998-09-27 | 22-187 | IND | NOR | L 13-19 | 19 | 32 | 59.4% | 309 | 1 | 3 | 63.2 | 9.66 | 6.06 | |
| 3 | 1998 | 12 | 1998-11-29 | 22-250 | IND | @ | BAL | L 31-38 | 27 | 42 | 64.3% | 357 | 3 | 1 | 105.0 | 8.50 | 8.86 |
| 4 | 1998 | 15 | 1998-12-20 | 22-271 | IND | @ | SEA | L 23-27 | 23 | 39 | 59.0% | 335 | 1 | 1 | 84.9 | 8.59 | 7.95 |
| Passing | |||||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Cmp | Att | Yds | TD | Int | |||||
| 5 | 1999 | 3 | 1999-09-26 | 23-186 | IND | @ | SDG | W 27-19 | 29 | 54 | 53.7% | 404 | 2 | 1 | 82.6 | 7.48 | 7.39 |
| 6 | 1999 | 7 | 1999-10-31 | 23-221 | IND | DAL | W 34-24 | 22 | 34 | 64.7% | 313 | 1 | 0 | 104.2 | 9.21 | 9.79 | |
| Passing | |||||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Cmp | Att | Yds | TD | Int | |||||
| 7 | 2000 | 2 | 2000-09-10 | 24-170 | IND | OAK | L 31-38 | 33 | 48 | 68.8% | 367 | 3 | 2 | 94.7 | 7.65 | 7.02 | |
| 8 | 2000 | 3 | 2000-09-25 | 24-185 | IND | JAX | W 43-14 | 23 | 36 | 63.9% | 440 | 4 | 0 | 143.3 | 12.22 | 14.44 | |
| 9 | 2000 | 5 | 2000-10-08 | 24-198 | IND | @ | NWE | L 16-24 | 31 | 54 | 57.4% | 334 | 1 | 3 | 58.7 | 6.19 | 4.06 |
| 10 | 2000 | 9 | 2000-11-05 | 24-226 | IND | @ | CHI | L 24-27 | 26 | 39 | 66.7% | 302 | 2 | 1 | 96.3 | 7.74 | 7.62 |
| 11 | 2000 | 13 | 2000-12-03 | 24-254 | IND | @ | NYJ | L 17-27 | 27 | 51 | 52.9% | 339 | 2 | 2 | 70.6 | 6.65 | 5.67 |
| 12 | 2000 | 16 | 2000-12-24 | 24-275 | IND | MIN | W 31-10 | 25 | 36 | 69.4% | 283 | 4 | 1 | 118.2 | 7.86 | 8.83 | |
| Passing | |||||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Cmp | Att | Yds | TD | Int | |||||
| 13 | 2001 | 2 | 2001-09-23 | 25-183 | IND | BUF | W 42-26 | 23 | 29 | 79.3% | 421 | 4 | 2 | 129.6 | 14.52 | 14.17 | |
| 14 | 2001 | 5 | 2001-10-21 | 25-211 | IND | NWE | L 17-38 | 22 | 34 | 64.7% | 335 | 1 | 0 | 106.9 | 9.85 | 10.44 | |
| 15 | 2001 | 10 | 2001-11-25 | 25-246 | IND | SFO | L 21-40 | 31 | 51 | 60.8% | 370 | 1 | 4 | 56.8 | 7.25 | 4.12 | |
| 16 | 2001 | 11 | 2001-12-02 | 25-253 | IND | @ | BAL | L 27-39 | 27 | 48 | 56.3% | 310 | 2 | 1 | 81.1 | 6.46 | 6.35 |
| 17 | 2001 | 13 | 2001-12-16 | 25-267 | IND | ATL | W 41-27 | 23 | 35 | 65.7% | 325 | 3 | 1 | 112.2 | 9.29 | 9.71 | |
| Passing | |||||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Cmp | Att | Yds | TD | Int | |||||
| 18 | 2002 | 6 | 2002-10-21 | 26-211 | IND | @ | PIT | L 10-28 | 32 | 48 | 66.7% | 304 | 1 | 3 | 64.9 | 6.33 | 3.94 |
| 19 | 2002 | 8 | 2002-11-03 | 26-224 | IND | TEN | L 15-23 | 37 | 50 | 74.0% | 327 | 2 | 1 | 96.0 | 6.54 | 6.44 | |
| 20 | 2002 | 9 | 2002-11-10 | 26-231 | IND | @ | PHI | W 35-13 | 18 | 23 | 78.3% | 319 | 3 | 0 | 158.3 | 13.87 | 16.48 |
| 21 | 2002 | 15 | 2002-12-22 | 26-273 | IND | NYG | L 27-44 | 30 | 46 | 65.2% | 365 | 3 | 2 | 93.1 | 7.93 | 7.28 | |
| Passing | |||||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Cmp | Att | Yds | TD | Int | |||||
| 22 | 2003 | 4 | 2003-09-28 | 27-188 | IND | @ | NOR | W 55-21 | 20 | 25 | 80.0% | 314 | 6 | 0 | 158.3 | 12.56 | 17.36 |
| 23 | 2003 | 5 | 2003-10-06 | 27-196 | IND | @ | TAM | W 38-35 | 34 | 47 | 72.3% | 386 | 2 | 1 | 101.9 | 8.21 | 8.11 |
| 24 | 2003 | 9 | 2003-11-09 | 27-230 | IND | @ | JAX | L 23-28 | 28 | 45 | 62.2% | 347 | 2 | 2 | 82.4 | 7.71 | 6.60 |
| 25 | 2003 | 10 | 2003-11-16 | 27-237 | IND | NYJ | W 38-31 | 27 | 36 | 75.0% | 401 | 1 | 0 | 120.3 | 11.14 | 11.69 | |
| 26 | 2003 | 12 | 2003-11-30 | 27-251 | IND | NWE | L 34-38 | 29 | 48 | 60.4% | 278 | 4 | 1 | 95.7 | 5.79 | 6.52 | |
| 27 | 2003 | 14 | 2003-12-14 | 27-265 | IND | ATL | W 38-7 | 25 | 30 | 83.3% | 290 | 5 | 0 | 146.5 | 9.67 | 13.00 | |
| 28 | 2003 | 17 | 2004-01-04 | 27-286 | IND | DEN | W 41-10 | 22 | 26 | 84.6% | 377 | 5 | 0 | 158.3 | 14.50 | 18.35 | |
| 29 | 2003 | 18 | 2004-01-11 | 27-293 | IND | @ | KAN | W 38-31 | 22 | 30 | 73.3% | 304 | 3 | 0 | 138.7 | 10.13 | 12.13 |
| Passing | |||||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Cmp | Att | Yds | TD | Int | |||||
| 30 | 2004 | 3 | 2004-09-26 | 28-186 | IND | GNB | W 45-31 | 28 | 40 | 70.0% | 393 | 5 | 0 | 140.9 | 9.83 | 12.33 | |
| 31 | 2004 | 6 | 2004-10-24 | 28-214 | IND | JAX | L 24-27 | 27 | 39 | 69.2% | 368 | 3 | 0 | 124.7 | 9.44 | 10.97 | |
| 32 | 2004 | 7 | 2004-10-31 | 28-221 | IND | @ | KAN | L 35-45 | 25 | 44 | 56.8% | 472 | 5 | 1 | 122.5 | 10.73 | 11.98 |
| 33 | 2004 | 8 | 2004-11-08 | 28-229 | IND | MIN | W 31-28 | 23 | 29 | 79.3% | 268 | 4 | 0 | 144.8 | 9.24 | 12.00 | |
| 34 | 2004 | 9 | 2004-11-14 | 28-235 | IND | HOU | W 49-14 | 18 | 27 | 66.7% | 320 | 5 | 2 | 115.7 | 11.85 | 12.22 | |
| 35 | 2004 | 10 | 2004-11-21 | 28-242 | IND | @ | CHI | W 41-10 | 17 | 28 | 60.7% | 211 | 4 | 1 | 108.8 | 7.54 | 8.79 |
| 36 | 2004 | 11 | 2004-11-25 | 28-246 | IND | @ | DET | W 41-9 | 23 | 28 | 82.1% | 236 | 6 | 0 | 141.4 | 8.43 | 12.71 |
| 37 | 2004 | 12 | 2004-12-05 | 28-256 | IND | TEN | W 51-24 | 25 | 33 | 75.8% | 425 | 3 | 2 | 122.3 | 12.88 | 11.97 | |
| 38 | 2004 | 15 | 2004-12-26 | 28-277 | IND | SDG | W 34-31 | 27 | 44 | 61.4% | 383 | 2 | 1 | 95.2 | 8.70 | 8.59 | |
| 39 | 2004 | 17 | 2005-01-09 | 28-291 | IND | DEN | W 49-24 | 27 | 33 | 81.8% | 458 | 4 | 1 | 145.7 | 13.88 | 14.94 | |
| Passing | |||||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Cmp | Att | Yds | TD | Int | |||||
| 40 | 2005 | 4 | 2005-10-02 | 29-192 | IND | @ | TEN | W 31-10 | 20 | 27 | 74.1% | 264 | 4 | 0 | 144.1 | 9.78 | 12.74 |
| 41 | 2005 | 8 | 2005-11-07 | 29-228 | IND | @ | NWE | W 40-21 | 28 | 37 | 75.7% | 321 | 3 | 1 | 117.1 | 8.68 | 9.08 |
| 42 | 2005 | 10 | 2005-11-20 | 29-241 | IND | @ | CIN | W 45-37 | 24 | 40 | 60.0% | 365 | 3 | 1 | 104.7 | 9.13 | 9.50 |
| 43 | 2005 | 13 | 2005-12-11 | 29-262 | IND | @ | JAX | W 26-18 | 24 | 36 | 66.7% | 324 | 2 | 0 | 113.7 | 9.00 | 10.11 |
| 44 | 2005 | 14 | 2005-12-18 | 29-269 | IND | SDG | L 17-26 | 26 | 45 | 57.8% | 336 | 1 | 2 | 70.2 | 7.47 | 5.91 | |
| Passing | |||||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Cmp | Att | Yds | TD | Int | |||||
| 45 | 2006 | 2 | 2006-09-17 | 30-177 | IND | HOU | W 43-24 | 26 | 38 | 68.4% | 400 | 3 | 0 | 129.3 | 10.53 | 12.11 | |
| 46 | 2006 | 6 | 2006-10-22 | 30-212 | IND | WAS | W 36-22 | 25 | 35 | 71.4% | 342 | 4 | 0 | 140.4 | 9.77 | 12.06 | |
| 47 | 2006 | 7 | 2006-10-29 | 30-219 | IND | @ | DEN | W 34-31 | 32 | 39 | 82.1% | 345 | 3 | 0 | 129.2 | 8.85 | 10.38 |
| 48 | 2006 | 8 | 2006-11-05 | 30-226 | IND | @ | NWE | W 27-20 | 20 | 36 | 55.6% | 326 | 2 | 1 | 93.1 | 9.06 | 8.92 |
| 49 | 2006 | 12 | 2006-12-03 | 30-254 | IND | @ | TEN | L 17-20 | 21 | 28 | 75.0% | 351 | 1 | 2 | 98.8 | 12.54 | 10.04 |
| 50 | 2006 | 13 | 2006-12-10 | 30-261 | IND | @ | JAX | L 17-44 | 25 | 50 | 50.0% | 313 | 0 | 1 | 61.5 | 6.26 | 5.36 |
| 51 | 2006 | 14 | 2006-12-18 | 30-269 | IND | CIN | W 34-16 | 29 | 36 | 80.6% | 282 | 4 | 0 | 136.3 | 7.83 | 10.06 | |
| 52 | 2006 | 19 | 2007-01-21 | 30-303 | IND | NWE | W 38-34 | 27 | 47 | 57.4% | 349 | 1 | 1 | 79.1 | 7.43 | 6.89 | |
| Passing | |||||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Cmp | Att | Yds | TD | Int | |||||
| 53 | 2007 | 2 | 2007-09-16 | 31-176 | IND | @ | TEN | W 22-20 | 28 | 42 | 66.7% | 312 | 1 | 1 | 86.6 | 7.43 | 6.83 |
| 54 | 2007 | 9 | 2007-11-11 | 31-232 | IND | @ | SDG | L 21-23 | 34 | 56 | 60.7% | 328 | 2 | 6 | 49.4 | 5.86 | 1.75 |
| 55 | 2007 | 12 | 2007-12-02 | 31-253 | IND | JAX | W 28-25 | 20 | 29 | 69.0% | 288 | 4 | 1 | 126.1 | 9.93 | 11.14 | |
| 56 | 2007 | 13 | 2007-12-09 | 31-260 | IND | @ | BAL | W 44-20 | 13 | 17 | 76.5% | 249 | 4 | 0 | 157.5 | 14.65 | 19.35 |
| 57 | 2007 | 15 | 2007-12-23 | 31-274 | IND | HOU | W 38-15 | 28 | 35 | 80.0% | 311 | 3 | 0 | 132.3 | 8.89 | 10.60 | |
| 58 | 2007 | 17 | 2008-01-13 | 31-295 | IND | SDG | L 24-28 | 33 | 48 | 68.8% | 402 | 3 | 2 | 97.7 | 8.38 | 7.75 | |
| Passing | |||||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Cmp | Att | Yds | TD | Int | |||||
| 59 | 2008 | 2 | 2008-09-14 | 32-174 | IND | @ | MIN | W 18-15 | 26 | 42 | 61.9% | 311 | 1 | 2 | 72.6 | 7.40 | 5.74 |
| 60 | 2008 | 10 | 2008-11-16 | 32-237 | IND | HOU | W 33-27 | 30 | 46 | 65.2% | 320 | 2 | 0 | 99.9 | 6.96 | 7.83 | |
| 61 | 2008 | 14 | 2008-12-14 | 32-265 | IND | DET | W 31-21 | 28 | 37 | 75.7% | 318 | 1 | 0 | 110.0 | 8.59 | 9.14 | |
| 62 | 2008 | 15 | 2008-12-18 | 32-269 | IND | @ | JAX | W 31-24 | 29 | 34 | 85.3% | 364 | 3 | 0 | 140.7 | 10.71 | 12.47 |
| 63 | 2008 | 17 | 2009-01-03 | 32-285 | IND | @ | SDG | L 17-23 | 25 | 42 | 59.5% | 310 | 1 | 0 | 90.4 | 7.38 | 7.86 |
| Passing | |||||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Cmp | Att | Yds | TD | Int | |||||
| 64 | 2009 | 1 | 2009-09-13 | 33-173 | IND | JAX | W 14-12 | 28 | 38 | 73.7% | 301 | 1 | 1 | 94.3 | 7.92 | 7.26 | |
| 65 | 2009 | 2 | 2009-09-21 | 33-181 | IND | @ | MIA | W 27-23 | 14 | 23 | 60.9% | 303 | 2 | 0 | 133.9 | 13.17 | 14.91 |
| 66 | 2009 | 3 | 2009-09-27 | 33-187 | IND | @ | ARI | W 31-10 | 24 | 35 | 68.6% | 379 | 4 | 1 | 130.5 | 10.83 | 11.83 |
| 67 | 2009 | 4 | 2009-10-04 | 33-194 | IND | SEA | W 34-17 | 31 | 41 | 75.6% | 353 | 2 | 1 | 107.1 | 8.61 | 8.49 | |
| 68 | 2009 | 5 | 2009-10-11 | 33-201 | IND | @ | TEN | W 31-9 | 36 | 44 | 81.8% | 309 | 3 | 1 | 109.2 | 7.02 | 7.36 |
| 69 | 2009 | 7 | 2009-11-01 | 33-222 | IND | SFO | W 18-14 | 31 | 48 | 64.6% | 347 | 0 | 0 | 86.0 | 7.23 | 7.23 | |
| 70 | 2009 | 8 | 2009-11-08 | 33-229 | IND | HOU | W 20-17 | 34 | 50 | 68.0% | 318 | 1 | 1 | 83.6 | 6.36 | 5.86 | |
| 71 | 2009 | 9 | 2009-11-15 | 33-236 | IND | NWE | W 35-34 | 28 | 44 | 63.6% | 327 | 4 | 2 | 97.4 | 7.43 | 7.20 | |