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Output includes all games that meet at least one of the following criteria: 300+ yards passing, 100+ yards rushing, 100+ yards receiving, or 4+ passing touchdowns.
| Rushing | Receiving | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Att | Yds | TD | Rec | Yds | TD | |||
| 1 | 2001 | 1 | 2001-09-09 | 22-078 | SDG | WAS | W 30-3 | 36 | 113 | 3.14 | 2 | 0 | 0 | 0 | ||
| 2 | 2001 | 3 | 2001-09-30 | 22-099 | SDG | CIN | W 28-14 | 21 | 107 | 5.10 | 3 | 0 | 0 | 0 | ||
| 3 | 2001 | 4 | 2001-10-07 | 22-106 | SDG | @ | CLE | L 16-20 | 19 | 102 | 5.37 | 1 | 0 | 0 | 0 | |
| 4 | 2001 | 15 | 2001-12-23 | 22-183 | SDG | @ | KAN | L 17-20 | 27 | 145 | 5.37 | 0 | 0 | 0 | 0 | |
| Rushing | Receiving | |||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Att | Yds | TD | Rec | Yds | TD | |||
| 5 | 2002 | 1 | 2002-09-08 | 23-077 | SDG | @ | CIN | W 34-6 | 21 | 114 | 5.43 | 1 | 0 | 0 | 0 | |
| 6 | 2002 | 4 | 2002-09-29 | 23-098 | SDG | NWE | W 21-14 | 27 | 217 | 8.04 | 2 | 0 | 0 | 0 | ||
| 7 | 2002 | 7 | 2002-10-20 | 23-119 | SDG | @ | OAK | W 27-21 | 39 | 153 | 3.92 | 1 | 0 | 0 | 0 | |
| 8 | 2002 | 9 | 2002-11-10 | 23-140 | SDG | @ | STL | L 24-28 | 24 | 120 | 5.00 | 1 | 0 | 0 | 0 | |
| 9 | 2002 | 12 | 2002-12-01 | 23-161 | SDG | DEN | W 30-27 | 37 | 220 | 5.95 | 3 | 0 | 0 | 0 | ||
| 10 | 2002 | 14 | 2002-12-15 | 23-175 | SDG | @ | BUF | L 13-20 | 28 | 110 | 3.93 | 1 | 0 | 0 | 0 | |
| 11 | 2002 | 15 | 2002-12-22 | 23-182 | SDG | @ | KAN | L 22-24 | 24 | 131 | 5.46 | 0 | 0 | 0 | 0 | |
| Rushing | Receiving | |||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Att | Yds | TD | Rec | Yds | TD | |||
| 12 | 2003 | 3 | 2003-09-21 | 24-090 | SDG | BAL | L 10-24 | 23 | 105 | 4.57 | 1 | 0 | 0 | 0 | ||
| 13 | 2003 | 4 | 2003-09-28 | 24-097 | SDG | @ | OAK | L 31-34 | 28 | 187 | 6.68 | 1 | 0 | 0 | 0 | |
| 14 | 2003 | 6 | 2003-10-19 | 24-118 | SDG | @ | CLE | W 26-20 | 26 | 200 | 7.69 | 1 | 0 | 0 | 0 | |
| 15 | 2003 | 9 | 2003-11-09 | 24-139 | SDG | MIN | W 42-28 | 16 | 162 | 10.13 | 2 | 0 | 0 | 0 | ||
| 16 | 2003 | 12 | 2003-11-30 | 24-160 | SDG | KAN | L 24-28 | 19 | 106 | 5.58 | 1 | 0 | 0 | 0 | ||
| 17 | 2003 | 13 | 2003-12-07 | 24-167 | SDG | @ | DET | W 14-7 | 0 | 0 | 0 | 9 | 148 | 16.44 | 2 | |
| 18 | 2003 | 14 | 2003-12-14 | 24-174 | SDG | GNB | L 21-38 | 0 | 0 | 0 | 11 | 144 | 13.09 | 2 | ||
| 19 | 2003 | 16 | 2003-12-28 | 24-188 | SDG | OAK | W 21-14 | 31 | 243 | 7.84 | 2 | 0 | 0 | 0 | ||
| Rushing | Receiving | |||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Att | Yds | TD | Rec | Yds | TD | |||
| 20 | 2004 | 1 | 2004-09-12 | 25-081 | SDG | @ | HOU | W 27-20 | 26 | 121 | 4.65 | 1 | 0 | 0 | 0 | |
| 21 | 2004 | 4 | 2004-10-03 | 25-102 | SDG | TEN | W 38-17 | 17 | 147 | 8.65 | 1 | 0 | 0 | 0 | ||
| 22 | 2004 | 10 | 2004-11-21 | 25-151 | SDG | @ | OAK | W 23-17 | 37 | 164 | 4.43 | 1 | 0 | 0 | 0 | |
| 23 | 2004 | 12 | 2004-12-05 | 25-165 | SDG | DEN | W 20-17 | 30 | 113 | 3.77 | 2 | 0 | 0 | 0 | ||
| 24 | 2004 | 13 | 2004-12-12 | 25-172 | SDG | TAM | W 31-24 | 25 | 131 | 5.24 | 1 | 0 | 0 | 0 | ||
| 25 | 2004 | 14 | 2004-12-19 | 25-179 | SDG | @ | CLE | W 21-0 | 26 | 111 | 4.27 | 2 | 0 | 0 | 0 | |
| Rushing | Receiving | |||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Att | Yds | TD | Rec | Yds | TD | |||
| 26 | 2005 | 3 | 2005-09-25 | 26-094 | SDG | NYG | W 45-23 | 21 | 192 | 9.14 | 3 | 0 | 0 | 0 | ||
| 27 | 2005 | 4 | 2005-10-02 | 26-101 | SDG | @ | NWE | W 41-17 | 25 | 134 | 5.36 | 2 | 0 | 0 | 0 | |
| 28 | 2005 | 6 | 2005-10-16 | 26-115 | SDG | @ | OAK | W 27-14 | 31 | 140 | 4.52 | 1 | 0 | 0 | 0 | |
| 29 | 2005 | 9 | 2005-11-06 | 26-136 | SDG | @ | NYJ | W 31-26 | 25 | 107 | 4.28 | 3 | 0 | 0 | 0 | |
| 30 | 2005 | 11 | 2005-11-27 | 26-157 | SDG | @ | WAS | W 23-17 | 25 | 184 | 7.36 | 3 | 0 | 0 | 0 | |
| Rushing | Receiving | |||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Att | Yds | TD | Rec | Yds | TD | |||
| 31 | 2006 | 1 | 2006-09-11 | 27-080 | SDG | @ | OAK | W 27-0 | 31 | 131 | 4.23 | 1 | 0 | 0 | 0 | |
| 32 | 2006 | 7 | 2006-10-29 | 27-128 | SDG | STL | W 38-24 | 25 | 183 | 7.32 | 2 | 0 | 0 | 0 | ||
| 33 | 2006 | 8 | 2006-11-05 | 27-135 | SDG | CLE | W 32-25 | 18 | 172 | 9.56 | 3 | 0 | 0 | 0 | ||
| 34 | 2006 | 9 | 2006-11-12 | 27-142 | SDG | @ | CIN | W 49-41 | 22 | 104 | 4.73 | 4 | 0 | 0 | 0 | |
| 35 | 2006 | 10 | 2006-11-19 | 27-149 | SDG | @ | DEN | W 35-27 | 20 | 105 | 5.25 | 3 | 0 | 0 | 0 | |
| 36 | 2006 | 11 | 2006-11-26 | 27-156 | SDG | OAK | W 21-14 | 19 | 109 | 5.74 | 2 | 0 | 0 | 0 | ||
| 37 | 2006 | 12 | 2006-12-03 | 27-163 | SDG | @ | BUF | W 24-21 | 28 | 178 | 6.36 | 2 | 0 | 0 | 0 | |
| 38 | 2006 | 13 | 2006-12-10 | 27-170 | SDG | DEN | W 48-20 | 28 | 103 | 3.68 | 3 | 0 | 0 | 0 | ||
| 39 | 2006 | 14 | 2006-12-17 | 27-177 | SDG | KAN | W 20-9 | 25 | 199 | 7.96 | 2 | 0 | 0 | 0 | ||
| 40 | 2006 | 15 | 2006-12-24 | 27-184 | SDG | @ | SEA | W 20-17 | 22 | 123 | 5.59 | 0 | 0 | 0 | 0 | |
| 41 | 2006 | 17 | 2007-01-14 | 27-205 | SDG | NWE | L 21-24 | 23 | 123 | 5.35 | 2 | 0 | 0 | 0 | ||
| Rushing | Receiving | |||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Att | Yds | TD | Rec | Yds | TD | |||
| 42 | 2007 | 4 | 2007-09-30 | 28-099 | SDG | KAN | L 16-30 | 20 | 132 | 6.60 | 1 | 0 | 0 | 0 | ||
| 43 | 2007 | 6 | 2007-10-14 | 28-113 | SDG | OAK | W 28-14 | 24 | 198 | 8.25 | 4 | 0 | 0 | 0 | ||
| 44 | 2007 | 12 | 2007-12-02 | 28-162 | SDG | @ | KAN | W 24-10 | 23 | 177 | 7.70 | 2 | 0 | 0 | 0 | |
| 45 | 2007 | 13 | 2007-12-09 | 28-169 | SDG | @ | TEN | W 23-17 | 26 | 146 | 5.62 | 1 | 0 | 0 | 0 | |
| 46 | 2007 | 14 | 2007-12-16 | 28-176 | SDG | DET | W 51-14 | 15 | 116 | 7.73 | 2 | 0 | 0 | 0 | ||
| 47 | 2007 | 15 | 2007-12-24 | 28-184 | SDG | DEN | W 23-3 | 19 | 107 | 5.63 | 1 | 0 | 0 | 0 | ||
| Rushing | Receiving | |||||||||||||||
| Rk | Year | G# | Date | Age | Tm | Opp | Result | Att | Yds | TD | Rec | Yds | TD | |||
| 48 | 2008 | 4 | 2008-09-28 | 29-097 | SDG | @ | OAK | W 28-18 | 20 | 106 | 5.30 | 2 | 0 | 0 | 0 | |
| 49 | 2008 | 8 | 2008-10-26 | 29-125 | SDG | @ | NOR | L 32-37 | 19 | 105 | 5.53 | 0 | 0 | 0 | 0 | |