| Single-season | Passing | Rushing | Receiving | Returns | Kicking | Scoring | |
| Career | Passing | Rushing | Receiving | Returns | Kicking | Scoring | Defense |
| Rk | From | To | G | QBrec | Cmp | Att | Yds | TD | Int | Lng | Sk | Yds | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jake Delhomme | 2003 | 2009 | 90 | 49-30-0 | 1566 | 2635 | 59.4 | 19128 | 120 | 4.6 | 85 | 3.2 | 80 | 7.3 | 6.7 | 12.2 | 212.5 | 83.6 | 151 | 1132 | 6.5 | 5.9 | 5.4 |
| 2 | Steve Beuerlein | 1996 | 2000 | 59 | 23-28-0 | 1041 | 1723 | 60.4 | 12690 | 86 | 5.0 | 50 | 2.9 | 88 | 7.4 | 7.1 | 12.2 | 215.1 | 87.7 | 191 | 1109 | 6.1 | 5.8 | 10.0 |
| 3 | Kerry Collins | 1995 | 1998 | 45 | 22-20-0 | 694 | 1340 | 51.8 | 8306 | 47 | 3.5 | 54 | 4.0 | 89 | 6.2 | 5.1 | 12.0 | 184.6 | 66.0 | 79 | 515 | 5.5 | 4.4 | 5.6 |
| 4 | Chris Weinke | 2001 | 2006 | 27 | 2-17-0 | 373 | 687 | 54.3 | 3800 | 14 | 2.0 | 26 | 3.8 | 48 | 5.5 | 4.2 | 10.2 | 140.7 | 61.4 | 42 | 267 | 4.8 | 3.6 | 5.8 |
| 5 | Rodney Peete | 2002 | 2004 | 16 | 8-7-0 | 228 | 392 | 58.2 | 2652 | 15 | 3.8 | 14 | 3.6 | 69 | 6.8 | 5.9 | 11.6 | 165.8 | 76.6 | 34 | 212 | 5.7 | 5.0 | 8.0 |
| 6 | Vinny Testaverde | 2007 | 2007 | 7 | 2-4-0 | 94 | 172 | 54.7 | 952 | 5 | 2.9 | 6 | 3.5 | 65 | 5.5 | 4.5 | 10.1 | 136.0 | 65.8 | 9 | 46 | 5.0 | 4.1 | 5.0 |
| 7 | David Carr | 2007 | 2007 | 6 | 1-3-0 | 73 | 136 | 53.7 | 635 | 3 | 2.2 | 5 | 3.7 | 38 | 4.7 | 3.5 | 8.7 | 105.8 | 58.3 | 13 | 74 | 3.8 | 2.7 | 8.7 |
| 8 | Matt Moore | 2007 | 2009 | 11 | 2-1-0 | 69 | 123 | 56.1 | 793 | 3 | 2.4 | 6 | 4.9 | 57 | 6.4 | 4.7 | 11.5 | 72.1 | 63.5 | 7 | 50 | 5.7 | 4.1 | 5.4 |
| 9 | Frank Reich | 1995 | 1995 | 3 | 0-3-0 | 37 | 84 | 44.0 | 441 | 2 | 2.4 | 2 | 2.4 | 46 | 5.3 | 4.7 | 11.9 | 147.0 | 58.7 | 12 | 100 | 3.6 | 3.0 | 12.5 |
| 10 | Randy Fasani | 2002 | 2002 | 4 | 0-1-0 | 15 | 44 | 34.1 | 171 | 0 | 0.0 | 4 | 9.1 | 27 | 3.9 | -0.2 | 11.4 | 42.8 | 8.8 | 7 | 60 | 2.2 | -1.4 | 13.7 |
| 11 | Jeff Lewis | 1999 | 2000 | 7 | 18 | 35 | 51.4 | 131 | 0 | 0.0 | 1 | 2.9 | 16 | 3.7 | 2.5 | 7.3 | 18.7 | 48.6 | 8 | 57 | 1.7 | 0.7 | 18.6 | |
| 12 | Matt Lytle | 2001 | 2001 | 3 | 0-1-0 | 17 | 30 | 56.7 | 133 | 1 | 3.3 | 3 | 10.0 | 28 | 4.4 | 0.6 | 7.8 | 44.3 | 39.3 | 3 | 24 | 3.3 | -0.2 | 9.1 |
| 13 | Jack Trudeau | 1995 | 1995 | 1 | 11 | 17 | 64.7 | 100 | 0 | 0.0 | 3 | 17.6 | 19 | 5.9 | -2.1 | 9.1 | 100.0 | 40.9 | 2 | 8 | 4.8 | -2.3 | 10.5 | |
| 14 | Brett Basanez | 2006 | 2006 | 1 | 6 | 11 | 54.5 | 56 | 0 | 0.0 | 1 | 9.1 | 18 | 5.1 | 1.0 | 9.3 | 56.0 | 30.9 | 0 | 0 | 5.1 | 1.0 | 0.0 | |
| 15 | Dameyune Craig | 2001 | 2001 | 2 | 4 | 8 | 50.0 | 34 | 0 | 0.0 | 0 | 0.0 | 18 | 4.3 | 4.3 | 8.5 | 17.0 | 61.5 | 2 | 15 | 1.9 | 1.9 | 20.0 | |
| 16 | Josh McCown | 2009 | 2009 | 1 | 1 | 6 | 16.7 | 2 | 0 | 0.0 | 0 | 0.0 | 2 | 0.3 | 0.3 | 2.0 | 2.0 | 39.6 | 1 | 6 | -0.6 | -0.6 | 14.3 | |
| 17 | Eric Guliford | 1995 | 1995 | 14 | 1 | 2 | 50.0 | 46 | 0 | 0.0 | 1 | 50.0 | 46 | 23.0 | 0.5 | 46.0 | 3.3 | 56.2 | 0 | 0 | 23.0 | 0.5 | 0.0 | |
| 18 | Ken Walter | 1998 | 2000 | 32 | 0 | 2 | 0.0 | 0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0.0 | 0.0 | 39.6 | 0 | 0 | 0.0 | 0.0 | 0.0 | ||
| 19 | Steve Bono | 1999 | 1999 | 2 | 0 | 1 | 0.0 | 0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0.0 | 0.0 | 39.6 | 0 | 0 | 0.0 | 0.0 | 0.0 | ||
| 20 | Dee Brown | 2002 | 2002 | 14 | 0 | 1 | 0.0 | 0 | 0 | 0.0 | 1 | 100.0 | 0 | 0.0 | -45.0 | 0.0 | 0.0 | 0 | 0 | 0.0 | -45.0 | 0.0 | ||
| 21 | William Floyd | 1998 | 1998 | 16 | 0 | 1 | 0.0 | 0 | 0 | 0.0 | 1 | 100.0 | 0 | 0.0 | -45.0 | 0.0 | 0.0 | 0 | 0 | 0.0 | -45.0 | 0.0 | ||
| 22 | DeShaun Foster | 2005 | 2005 | 15 | 0 | 1 | 0.0 | 0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0.0 | 0.0 | 39.6 | 0 | 0 | 0.0 | 0.0 | 0.0 | ||
| 23 | Richard Huntley | 2001 | 2001 | 14 | 0 | 1 | 0.0 | 0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0.0 | 0.0 | 39.6 | 1 | 0 | 0.0 | 0.0 | 50.0 | ||
| 24 | Keyshawn Johnson | 2006 | 2006 | 16 | 0 | 1 | 0.0 | 0 | 0 | 0.0 | 1 | 100.0 | 0 | 0.0 | -45.0 | 0.0 | 0.0 | 0 | 0 | 0.0 | -45.0 | 0.0 | ||
| 25 | Ricky Proehl | 2004 | 2004 | 16 | 0 | 1 | 0.0 | 0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0.0 | 0.0 | 39.6 | 0 | 0 | 0.0 | 0.0 | 0.0 | ||
| 26 | Todd Sauerbrun | 2003 | 2003 | 16 | 0 | 1 | 0.0 | 0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0.0 | 0.0 | 39.6 | 0 | 0 | 0.0 | 0.0 | 0.0 | ||
| 27 | Steve Smith | 2004 | 2004 | 1 | 0 | 1 | 0.0 | 0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0.0 | 0.0 | 39.6 | 0 | 0 | 0.0 | 0.0 | 0.0 | ||
| 28 | Vince Workman | 1995 | 1995 | 9 | 0 | 1 | 0.0 | 0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0.0 | 0.0 | 39.6 | 0 | 0 | 0.0 | 0.0 | 0.0 |