| Single-season | Passing | Rushing | Receiving | Returns | Kicking | Scoring | |
| Career | Passing | Rushing | Receiving | Returns | Kicking | Scoring | Defense |
| Rushing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Rk | From | To | G | Att | Yds | TD | Lng | Fmb | |||
| 1 | DeShaun Foster | 2003 | 2007 | 63 | 851 | 3336 | 10 | 71 | 3.9 | 53.0 | 16 |
| 2 | DeAngelo Williams | 2006 | 2009 | 58 | 754 | 3850 | 30 | 77 | 5.1 | 66.4 | 5 |
| 3 | Tim Biakabutuka | 1996 | 2001 | 50 | 611 | 2530 | 14 | 67 | 4.1 | 50.6 | 12 |
| 4 | Stephen Davis | 2003 | 2005 | 29 | 522 | 2085 | 20 | 40 | 4.0 | 71.9 | 5 |
| 5 | Fred Lane | 1997 | 1999 | 42 | 502 | 2001 | 13 | 50 | 4.0 | 47.6 | 9 |
| 6 | Anthony Johnson | 1995 | 1999 | 71 | 482 | 1795 | 7 | 29 | 3.7 | 25.3 | 8 |
| 7 | Jonathan Stewart | 2008 | 2009 | 32 | 405 | 1969 | 20 | 67 | 4.9 | 61.5 | 5 |
| 8 | Nick Goings | 2001 | 2008 | 101 | 400 | 1470 | 6 | 57 | 3.7 | 14.6 | 5 |
| 9 | Brad Hoover | 2000 | 2009 | 148 | 284 | 961 | 3 | 35 | 3.4 | 6.5 | 7 |
| 10 | Lamar Smith | 2002 | 2002 | 11 | 209 | 737 | 7 | 59 | 3.5 | 67.0 | 2 |
| 11 | Derrick Moore | 1995 | 1995 | 13 | 195 | 740 | 4 | 53 | 3.8 | 56.9 | 4 |
| 12 | Richard Huntley | 2001 | 2001 | 14 | 165 | 665 | 2 | 25 | 4.0 | 47.5 | 3 |
| 13 | Jake Delhomme | 2003 | 2009 | 91 | 152 | 260 | 5 | 13 | 1.7 | 2.9 | 57 |
| 14 | Steve Beuerlein | 1996 | 2000 | 59 | 109 | 305 | 3 | 20 | 2.8 | 5.2 | 44 |
| 15 | Kerry Collins | 1995 | 1998 | 45 | 107 | 217 | 4 | 21 | 2.0 | 4.8 | 32 |
| 16 | Dee Brown | 2002 | 2002 | 14 | 102 | 360 | 4 | 24 | 3.5 | 25.7 | 4 |
| 17 | William Floyd | 1998 | 2000 | 42 | 79 | 182 | 7 | 16 | 2.3 | 4.3 | 2 |
| 18 | Howard Griffith | 1995 | 1996 | 31 | 77 | 204 | 2 | 15 | 2.6 | 6.6 | 2 |
| 19 | Chris Weinke | 2001 | 2006 | 27 | 54 | 148 | 6 | 23 | 2.7 | 5.5 | 13 |
| 20 | Winslow Oliver | 1996 | 1997 | 22 | 48 | 183 | 0 | 16 | 3.8 | 8.3 | 6 |
| 21 | Steve Smith | 2001 | 2009 | 120 | 47 | 295 | 2 | 39 | 6.3 | 2.5 | 25 |
| 22 | Scott Greene | 1997 | 1997 | 16 | 45 | 157 | 1 | 10 | 3.5 | 9.8 | 1 |
| 23 | Bob Christian | 1995 | 1995 | 14 | 41 | 158 | 0 | 17 | 3.9 | 11.3 | 1 |
| 24 | Vince Workman | 1995 | 1995 | 9 | 35 | 139 | 1 | 14 | 4.0 | 15.4 | 0 |
| 25 | Chris Hetherington | 1999 | 2001 | 46 | 30 | 84 | 2 | 14 | 2.8 | 1.8 | 0 |
| 26 | Rod Smart | 2002 | 2005 | 47 | 27 | 61 | 0 | 6 | 2.3 | 1.3 | 4 |
| 27 | Randy Baldwin | 1995 | 1995 | 7 | 23 | 61 | 0 | 9 | 2.7 | 8.7 | 1 |
| 28 | Rodney Peete | 2002 | 2004 | 15 | 23 | 13 | 0 | 10 | 0.6 | 0.9 | 10 |
| 29 | Mike Goodson | 2009 | 2009 | 7 | 22 | 49 | 0 | 11 | 2.2 | 7.0 | 1 |
| Rushing | |||||||||||
| Rk | From | To | G | Att | Yds | TD | Lng | Fmb | |||
| 30 | Blair Thomas | 1995 | 1995 | 7 | 22 | 90 | 0 | 13 | 4.1 | 12.9 | 0 |
| 31 | Randy Fasani | 2002 | 2002 | 4 | 18 | 95 | 0 | 19 | 5.3 | 23.8 | 2 |
| 32 | David Carr | 2007 | 2007 | 6 | 17 | 59 | 0 | 15 | 3.5 | 9.8 | 1 |
| 33 | Joey Harris | 2004 | 2004 | 4 | 15 | 53 | 0 | 19 | 3.5 | 13.3 | 0 |
| 34 | Rocket Ismail | 1996 | 1998 | 42 | 15 | 154 | 1 | 36 | 10.3 | 3.7 | 2 |
| 35 | Matt Moore | 2007 | 2009 | 16 | 15 | 2 | 0 | 5 | 0.1 | 0.1 | 4 |
| 36 | Jamal Robertson | 2005 | 2005 | 6 | 14 | 41 | 1 | 11 | 2.9 | 6.8 | 1 |
| 37 | Jeff Lewis | 1999 | 2000 | 7 | 12 | 37 | 0 | 19 | 3.1 | 5.3 | 1 |
| 38 | Dino Philyaw | 1996 | 1996 | 9 | 12 | 38 | 1 | 8 | 3.2 | 4.2 | 0 |
| 39 | Tyrell Sutton | 2009 | 2009 | 6 | 12 | 68 | 0 | 20 | 5.7 | 11.3 | 0 |
| 40 | Muhsin Muhammad | 1996 | 2004 | 70 | 11 | 64 | 0 | 20 | 5.8 | 0.9 | 7 |
| 41 | Vinny Testaverde | 2007 | 2007 | 7 | 9 | 22 | 0 | 16 | 2.4 | 3.1 | 3 |
| 42 | Michael Bates | 1999 | 2000 | 32 | 8 | 25 | 0 | 12 | 3.1 | 0.8 | 5 |
| 43 | Eric Shelton | 2006 | 2006 | 9 | 8 | 23 | 0 | 9 | 2.9 | 2.6 | 0 |
| 44 | Rae Carruth | 1997 | 1999 | 20 | 7 | 27 | 0 | 6 | 3.9 | 1.4 | 2 |
| 45 | Joe Montgomery | 2002 | 2002 | 3 | 7 | 20 | 0 | 5 | 2.9 | 6.7 | 0 |
| 46 | Brandon Bennett | 2004 | 2004 | 8 | 6 | 17 | 1 | 11 | 2.8 | 2.1 | 0 |
| 47 | Dameyune Craig | 2000 | 2001 | 6 | 5 | 24 | 0 | 13 | 4.8 | 4.0 | 1 |
| 48 | Leroy Hoard | 1996 | 1996 | 3 | 5 | 11 | 0 | 5 | 2.2 | 3.7 | 0 |
| 49 | Ken Walter | 1997 | 2000 | 48 | 5 | -5 | 0 | 0 | -1.0 | -0.1 | 4 |
| 50 | Josh McCown | 2008 | 2008 | 2 | 4 | -3 | 0 | 0 | -0.8 | -1.5 | 0 |
| 51 | Mark Carrier | 1995 | 1995 | 16 | 3 | -4 | 0 | 4 | -1.3 | -0.3 | 0 |
| 52 | Alex Haynes | 2007 | 2007 | 10 | 3 | 3 | 0 | 3 | 1.0 | 0.3 | 0 |
| 53 | Steve Bono | 1999 | 1999 | 2 | 2 | -2 | 0 | -1 | -1.0 | -1.0 | 0 |
| 54 | Isaac Byrd | 2001 | 2002 | 28 | 2 | -2 | 0 | 0 | -1.0 | -0.1 | 1 |
| 55 | Drew Carter | 2006 | 2006 | 14 | 2 | 18 | 0 | 11 | 9.0 | 1.3 | 0 |
| 56 | Eric Guliford | 1995 | 1995 | 14 | 2 | 2 | 0 | 1 | 1.0 | 0.1 | 1 |
| 57 | Karl Hankton | 2002 | 2002 | 16 | 2 | -4 | 0 | 2 | -2.0 | -0.3 | 0 |
| 58 | Patrick Jeffers | 1999 | 1999 | 15 | 2 | 16 | 0 | 23 | 8.0 | 1.1 | 0 |
| 59 | Matt Lytle | 2001 | 2001 | 3 | 2 | 8 | 0 | 4 | 4.0 | 2.7 | 0 |
| Rushing | |||||||||||
| Rk | From | To | G | Att | Yds | TD | Lng | Fmb | |||
| 60 | Eric Metcalf | 1999 | 1999 | 16 | 2 | 20 | 0 | 17 | 10.0 | 1.3 | 2 |
| 61 | Ricky Proehl | 2004 | 2005 | 32 | 2 | 1 | 0 | 9 | 0.5 | 0.0 | 0 |
| 62 | Dwight Stone | 1995 | 1996 | 32 | 2 | 9 | 0 | 6 | 4.5 | 0.3 | 0 |
| 63 | Brett Basanez | 2006 | 2006 | 1 | 1 | 2 | 0 | 2 | 2.0 | 2.0 | 0 |
| 64 | Keary Colbert | 2005 | 2005 | 16 | 1 | 6 | 0 | 6 | 6.0 | 0.4 | 1 |
| 65 | Willie Green | 1996 | 1996 | 15 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| 66 | Dwayne Jarrett | 2007 | 2007 | 7 | 1 | 11 | 0 | 11 | 11.0 | 1.6 | 0 |
| 67 | Keyshawn Johnson | 2006 | 2006 | 16 | 1 | 4 | 1 | 4 | 4.0 | 0.3 | 1 |
| 68 | Frank Reich | 1995 | 1995 | 3 | 1 | 3 | 0 | 3 | 3.0 | 1.0 | 3 |
| 69 | Todd Sauerbrun | 2001 | 2001 | 16 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |