Regular Season Record (all-time) : 522-423-15
Playoff Record (all-time) : 26-18 (Last appearance after 2002 season)
Super Bowls Won: 5 out of 5 appearances
Championships Won: 5
Passing Leader (all-time): Joe Montana - 35,124 yards
Rushing Leader (all-time): Joe Perry - 8,689 yards
Receiving Leader (all-time): Jerry Rice - 19,247 yards
Winningest Coach (all-time): George Seifert - 98 wins
Top Player by Approximate Value (all-time): Jerry Rice - 215 AV
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| Single-season | Passing | Rushing | Receiving | Returns | Kicking | Scoring | ||
| Career | Passing | Rushing | Receiving | Returns | Kicking | Scoring | Defense | Approximate Value |
| Rushing | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rk | From | To | G | AV | Att | Yds | TD | Lng | Fmb | |||
| 1 | Joe Perry | 1948 | 1963 | 156 | 84 | 1667 | 8689 | 68 | 78 | 5.2 | 55.7 | 60 |
| 2 | Frank Gore | 2005 | 2011 | 84 | 59 | 1653 | 7625 | 43 | 80 | 4.6 | 90.8 | 28 |
| 3 | Roger Craig | 1983 | 1990 | 121 | 100 | 1686 | 7064 | 50 | 71 | 4.2 | 58.4 | 37 |
| 4 | Ken Willard | 1965 | 1973 | 125 | 71 | 1582 | 5930 | 45 | 69 | 3.7 | 47.4 | 41 |
| 5 | Garrison Hearst | 1997 | 2003 | 73 | 63 | 1189 | 5535 | 26 | 96 | 4.7 | 75.8 | 13 |
| 6 | J.D. Smith | 1958 | 1964 | 80 | 56 | 1007 | 4370 | 37 | 80 | 4.3 | 54.6 | 15 |
| 7 | Hugh McElhenny | 1952 | 1960 | 97 | 93 | 877 | 4288 | 35 | 89 | 4.9 | 44.2 | 43 |
| 8 | Kevan Barlow | 2001 | 2005 | 72 | 35 | 891 | 3614 | 24 | 78 | 4.1 | 50.2 | 12 |
| 9 | Steve Young | 1987 | 1999 | 150 | 158 | 608 | 3581 | 37 | 49 | 5.9 | 23.9 | 53 |
| 10 | Johnny Strzykalski | 1946 | 1952 | 81 | 18 | 662 | 3415 | 19 | 50 | 5.2 | 42.2 | 2 |
| 11 | Wendell Tyler | 1983 | 1986 | 48 | 30 | 624 | 3112 | 17 | 40 | 5.0 | 64.8 | 27 |
| 12 | Delvin Williams | 1974 | 1977 | 54 | 35 | 669 | 2966 | 20 | 80 | 4.4 | 54.9 | 12 |
| 13 | Wilbur Jackson | 1974 | 1979 | 72 | 36 | 745 | 2955 | 10 | 80 | 4.0 | 41.0 | 24 |
| 14 | Ricky Watters | 1992 | 1994 | 43 | 49 | 653 | 2840 | 25 | 43 | 4.3 | 66.0 | 15 |
| 15 | Charlie Garner | 1999 | 2000 | 32 | 30 | 499 | 2371 | 11 | 53 | 4.8 | 74.1 | 8 |
| 16 | Tom Rathman | 1986 | 1993 | 115 | 44 | 516 | 1902 | 26 | 35 | 3.7 | 16.5 | 7 |
| 17 | Norm Standlee | 1946 | 1952 | 76 | 20 | 405 | 1830 | 18 | 57 | 4.5 | 24.1 | 2 |
| 18 | Vic Washington | 1971 | 1973 | 40 | 27 | 483 | 1813 | 14 | 42 | 3.8 | 45.3 | 26 |
| 19 | Paul Hofer | 1976 | 1981 | 77 | 26 | 416 | 1746 | 16 | 47 | 4.2 | 22.7 | 15 |
| 20 | Larry Schreiber | 1971 | 1975 | 60 | 24 | 502 | 1734 | 10 | 23 | 3.5 | 28.9 | 13 |
| 21 | Joe Montana | 1979 | 1992 | 167 | 146 | 414 | 1595 | 20 | 21 | 3.9 | 9.6 | 45 |
| 22 | Jeff Garcia | 1999 | 2003 | 74 | 74 | 318 | 1571 | 21 | 33 | 4.9 | 21.2 | 32 |
| 23 | Doug Cunningham | 1967 | 1973 | 82 | 25 | 401 | 1498 | 10 | 64 | 3.7 | 18.3 | 20 |
| 24 | John David Crow | 1965 | 1968 | 56 | 31 | 370 | 1474 | 5 | 39 | 4.0 | 26.3 | 7 |
| 25 | Gary Lewis | 1964 | 1969 | 72 | 16 | 343 | 1421 | 13 | 60 | 4.1 | 19.7 | 12 |
| 26 | Frankie Albert | 1946 | 1952 | 90 | 27 | 329 | 1272 | 27 | 42 | 3.9 | 14.1 | 7 |
| 27 | Terry Kirby | 1996 | 1998 | 39 | 19 | 307 | 1235 | 12 | 38 | 4.0 | 31.7 | 4 |
| 28 | Len Eshmont | 1946 | 1949 | 48 | 0 | 232 | 1181 | 7 | 0 | 5.1 | 24.6 | 0 |
| 29 | John Brodie | 1957 | 1973 | 201 | 140 | 235 | 1167 | 22 | 38 | 5.0 | 5.8 | 48 |
| Rushing | ||||||||||||
| Rk | From | To | G | AV | Att | Yds | TD | Lng | Fmb | |||
| 30 | Earl Cooper | 1980 | 1985 | 72 | 25 | 298 | 1152 | 6 | 47 | 3.9 | 16.0 | 12 |
| 31 | Billy Kilmer | 1961 | 1966 | 39 | 14 | 228 | 1123 | 15 | 35 | 4.9 | 28.8 | 16 |
| 32 | O.J. Simpson | 1978 | 1979 | 23 | 9 | 281 | 1053 | 4 | 34 | 3.7 | 45.8 | 8 |
| 33 | Derek Loville | 1994 | 1996 | 42 | 15 | 319 | 1051 | 12 | 27 | 3.3 | 25.0 | 1 |
| 34 | John Henry Johnson | 1954 | 1956 | 31 | 14 | 228 | 1051 | 12 | 54 | 4.6 | 33.9 | 6 |
| 35 | Dexter Carter | 1990 | 1996 | 90 | 20 | 247 | 1042 | 5 | 74 | 4.2 | 11.6 | 26 |
| 36 | Verl Lillywhite | 1948 | 1951 | 47 | 13 | 196 | 1004 | 6 | 60 | 5.1 | 21.4 | 4 |
| 37 | Joe Arenas | 1951 | 1957 | 72 | 26 | 203 | 987 | 10 | 60 | 4.9 | 13.7 | 19 |
| 38 | William Floyd | 1994 | 1997 | 48 | 27 | 276 | 959 | 13 | 26 | 3.5 | 20.0 | 7 |
| 39 | Joe Cribbs | 1986 | 1987 | 25 | 12 | 222 | 890 | 6 | 20 | 4.0 | 35.6 | 6 |
| 40 | Maurice Hicks | 2004 | 2007 | 55 | 8 | 205 | 869 | 6 | 73 | 4.2 | 15.8 | 8 |
| 41 | Jimmy Thomas | 1969 | 1973 | 63 | 17 | 165 | 824 | 4 | 75 | 5.0 | 13.1 | 7 |
| 42 | Bill Ring | 1981 | 1986 | 69 | 10 | 183 | 732 | 7 | 34 | 4.0 | 10.6 | 3 |
| 43 | Bob Ferrell | 1976 | 1979 | 56 | 6 | 183 | 692 | 3 | 20 | 3.8 | 12.4 | 10 |
| 44 | Keith Henderson | 1989 | 1992 | 24 | 10 | 160 | 642 | 3 | 25 | 4.0 | 26.8 | 8 |
| 45 | Harry Sydney | 1987 | 1991 | 69 | 8 | 139 | 642 | 7 | 32 | 4.6 | 9.3 | 7 |
| 46 | Y.A. Tittle | 1951 | 1960 | 112 | 89 | 196 | 637 | 23 | 45 | 3.3 | 5.7 | 32 |
| 47 | C.R. Roberts | 1959 | 1962 | 27 | 11 | 155 | 637 | 4 | 54 | 4.1 | 23.6 | 5 |
| 48 | Alex Smith | 2005 | 2011 | 54 | 21 | 181 | 629 | 4 | 25 | 3.5 | 11.6 | 41 |
| 49 | Jerry Rice | 1985 | 2000 | 222 | 203 | 84 | 625 | 10 | 43 | 7.4 | 2.8 | 21 |
| 50 | Fred Beasley | 1999 | 2004 | 89 | 25 | 183 | 610 | 8 | 44 | 3.3 | 6.9 | 3 |
| 51 | Amp Lee | 1992 | 1993 | 31 | 9 | 163 | 592 | 3 | 43 | 3.6 | 19.1 | 2 |
| 52 | Dave Kopay | 1964 | 1967 | 48 | 8 | 156 | 577 | 3 | 32 | 3.7 | 12.0 | 5 |
| 53 | Don Lisbon | 1963 | 1964 | 20 | 7 | 164 | 561 | 0 | 25 | 3.4 | 28.1 | 6 |
| 54 | Ricky Patton | 1980 | 1981 | 25 | 5 | 153 | 544 | 4 | 28 | 3.6 | 21.8 | 4 |
| 55 | Sam Cathcart | 1949 | 1952 | 36 | 8 | 108 | 509 | 1 | 57 | 4.7 | 14.1 | 0 |
| 56 | Lenvil Elliott | 1979 | 1981 | 35 | 9 | 116 | 505 | 5 | 20 | 4.4 | 14.4 | 9 |
| 57 | Pete Schabarum | 1951 | 1954 | 34 | 7 | 115 | 494 | 3 | 67 | 4.3 | 14.5 | 5 |
| 58 | Earle Parsons | 1946 | 1947 | 21 | 0 | 107 | 487 | 2 | 0 | 4.6 | 23.2 | 0 |
| 59 | Sammy Johnson | 1974 | 1976 | 34 | 7 | 123 | 474 | 7 | 32 | 3.9 | 13.9 | 4 |
| Rushing | ||||||||||||
| Rk | From | To | G | AV | Att | Yds | TD | Lng | Fmb | |||
| 60 | Kendall Hunter | 2011 | 2011 | 112 | 473 | 2 | 44 | 4.2 | 1 | |||
| 61 | Marc Logan | 1992 | 1994 | 40 | 11 | 99 | 467 | 9 | 45 | 4.7 | 11.7 | 2 |
| 62 | Forrest Hall | 1948 | 1948 | 14 | 0 | 66 | 413 | 2 | 65 | 6.3 | 29.5 | 0 |
| 63 | George Mira | 1964 | 1968 | 47 | 9 | 41 | 372 | 0 | 38 | 9.1 | 7.9 | 17 |
| 64 | Greg Boykin | 1978 | 1978 | 16 | 3 | 102 | 361 | 2 | 23 | 3.5 | 22.6 | 3 |
| 65 | Derrick Harmon | 1984 | 1986 | 39 | 5 | 94 | 361 | 2 | 19 | 3.8 | 9.3 | 4 |
| 66 | Jim Cason | 1948 | 1954 | 55 | 25 | 82 | 351 | 4 | 59 | 4.3 | 6.4 | 5 |
| 67 | Bill Tucker | 1967 | 1970 | 55 | 8 | 95 | 349 | 6 | 24 | 3.7 | 6.3 | 8 |
| 68 | Brian Westbrook | 2010 | 2010 | 14 | 3 | 77 | 340 | 4 | 30 | 4.4 | 24.3 | 0 |
| 69 | Gene Babb | 1957 | 1958 | 24 | 8 | 109 | 339 | 3 | 19 | 3.1 | 14.1 | 4 |
| 70 | Ned Mathews | 1946 | 1947 | 18 | 0 | 57 | 332 | 2 | 0 | 5.8 | 18.4 | 0 |
| 71 | Terry Jackson | 1999 | 2005 | 79 | 11 | 70 | 331 | 2 | 15 | 4.7 | 4.2 | 5 |
| 72 | Freddie Solomon | 1978 | 1985 | 114 | 52 | 47 | 329 | 3 | 56 | 7.0 | 2.9 | 20 |
| 73 | Jeff Moore | 1982 | 1983 | 24 | 12 | 100 | 324 | 5 | 19 | 3.2 | 13.5 | 4 |
| 74 | Anthony Dixon | 2010 | 2011 | 16 | 1 | 99 | 324 | 4 | 34 | 3.3 | 20.3 | 0 |
| 75 | Dicky Moegle | 1955 | 1959 | 43 | 26 | 60 | 310 | 6 | 39 | 5.2 | 7.2 | 2 |
| 76 | Johnny Davis | 1981 | 1981 | 16 | 2 | 94 | 297 | 7 | 14 | 3.2 | 18.6 | 1 |
| 77 | Michael Robinson | 2006 | 2009 | 62 | 4 | 86 | 289 | 2 | 33 | 3.4 | 4.7 | 2 |
| 78 | Eddie Carr | 1947 | 1949 | 30 | 0 | 44 | 283 | 3 | 0 | 6.4 | 9.4 | 0 |
| 79 | Mike Lind | 1963 | 1964 | 24 | 6 | 108 | 282 | 7 | 21 | 2.6 | 11.8 | 3 |
| 80 | Bob Waters | 1960 | 1963 | 30 | 5 | 65 | 281 | 3 | 35 | 4.3 | 9.4 | 7 |
| 81 | Walt Easley | 1981 | 1982 | 13 | 2 | 81 | 235 | 1 | 9 | 2.9 | 18.1 | 2 |
| 82 | DeShaun Foster | 2008 | 2008 | 16 | 3 | 76 | 234 | 1 | 18 | 3.1 | 14.6 | 2 |
| 83 | Don Woods | 1980 | 1980 | 10 | 3 | 50 | 229 | 0 | 23 | 4.6 | 22.9 | 2 |
| 84 | Glen Coffee | 2009 | 2009 | 14 | 2 | 83 | 226 | 1 | 17 | 2.7 | 16.1 | 0 |
| 85 | Joe Reed | 1972 | 1974 | 21 | 5 | 35 | 214 | 0 | 27 | 6.1 | 10.2 | 6 |
| 86 | Steve Spurrier | 1967 | 1975 | 89 | 21 | 49 | 210 | 2 | 29 | 4.3 | 2.4 | 14 |
| 87 | Jamal Robertson | 2003 | 2004 | 16 | 2 | 48 | 207 | 1 | 23 | 4.3 | 12.9 | 3 |
| 88 | Chuck Levy | 1997 | 1998 | 26 | 4 | 41 | 202 | 1 | 24 | 4.9 | 7.8 | 1 |
| 89 | Joe Vetrano | 1946 | 1949 | 53 | 0 | 56 | 201 | 2 | 0 | 3.6 | 3.8 | 0 |
| Rushing | ||||||||||||
| Rk | From | To | G | AV | Att | Yds | TD | Lng | Fmb | |||
| 90 | Shaun Hill | 2007 | 2009 | 18 | 11 | 44 | 199 | 3 | 24 | 4.5 | 11.1 | 14 |
| 91 | Tommy Vardell | 1996 | 1999 | 17 | 4 | 64 | 198 | 3 | 17 | 3.1 | 11.6 | 0 |
| 92 | Billy Mixon | 1953 | 1954 | 22 | 8 | 32 | 195 | 1 | 33 | 6.1 | 8.9 | 0 |
| 93 | Paul Smith | 2000 | 2002 | 36 | 2 | 40 | 189 | 1 | 16 | 4.7 | 5.3 | 3 |
| 94 | Scott Bull | 1976 | 1978 | 36 | 5 | 49 | 186 | 3 | 18 | 3.8 | 5.2 | 10 |
| 95 | Anthony Lynn | 1995 | 1996 | 22 | 1 | 26 | 175 | 0 | 67 | 6.7 | 8.0 | 0 |
| 96 | Ted Kwalick | 1970 | 1973 | 56 | 37 | 19 | 175 | 0 | 45 | 9.2 | 3.1 | 5 |
| 97 | Len Masini | 1947 | 1947 | 11 | 0 | 38 | 167 | 2 | 0 | 4.4 | 15.2 | 0 |
| 98 | Jim Plunkett | 1976 | 1977 | 26 | 17 | 47 | 166 | 1 | 12 | 3.5 | 6.4 | 3 |
| 99 | Bishop Strickland | 1951 | 1951 | 9 | 1 | 34 | 165 | 0 | 15 | 4.9 | 18.3 | 2 |
| 100 | Terrell Owens | 1998 | 2003 | 75 | 72 | 21 | 162 | 2 | 38 | 7.7 | 2.2 | 4 |
| 101 | Jim Vollenweider | 1962 | 1963 | 27 | 2 | 58 | 161 | 2 | 12 | 2.8 | 6.0 | 1 |
| 102 | James Pace | 1958 | 1958 | 12 | 1 | 52 | 161 | 2 | 34 | 3.1 | 13.4 | 0 |
| 103 | Bob Gaiters | 1962 | 1962 | 9 | 2 | 36 | 158 | 0 | 53 | 4.4 | 17.6 | 1 |
| 104 | Phil Francis | 1979 | 1980 | 21 | 3 | 38 | 154 | 1 | 16 | 4.1 | 7.3 | 2 |
| 105 | Doug DuBose | 1987 | 1988 | 16 | 2 | 34 | 149 | 2 | 37 | 4.4 | 9.3 | 2 |
| 106 | Terrence Flagler | 1987 | 1989 | 21 | 3 | 42 | 145 | 1 | 29 | 3.5 | 6.9 | 7 |
| 107 | J.T. O'Sullivan | 2008 | 2008 | 9 | 6 | 30 | 145 | 0 | 18 | 4.8 | 16.1 | 11 |
| 108 | Lawrence Phillips | 1999 | 1999 | 8 | 2 | 30 | 144 | 2 | 68 | 4.8 | 18.0 | 2 |
| 109 | Don Durdan | 1946 | 1947 | 13 | 0 | 33 | 134 | 0 | 2 | 4.1 | 10.3 | 0 |
| 110 | Kermit Johnson | 1975 | 1976 | 22 | 1 | 36 | 124 | 1 | 19 | 3.4 | 5.6 | 2 |
| 111 | Bob Sullivan | 1948 | 1948 | 13 | 0 | 33 | 121 | 0 | 0 | 3.7 | 9.3 | 0 |
| 112 | Troy Smith | 2010 | 2010 | 6 | 4 | 23 | 121 | 1 | 16 | 5.3 | 20.2 | 6 |
| 113 | Don Garlin | 1949 | 1950 | 19 | 1 | 24 | 116 | 1 | 60 | 4.8 | 6.1 | 0 |
| 114 | Adam Walker | 1993 | 1995 | 31 | 2 | 32 | 115 | 2 | 16 | 3.6 | 3.7 | 2 |
| 115 | Lloyd Winston | 1962 | 1963 | 6 | 1 | 28 | 112 | 1 | 38 | 4.0 | 18.7 | 1 |
| 116 | Marc Edwards | 1997 | 1998 | 31 | 7 | 27 | 111 | 1 | 32 | 4.1 | 3.6 | 0 |
| 117 | Tony Cherry | 1986 | 1987 | 6 | 1 | 24 | 107 | 1 | 16 | 4.5 | 17.8 | 2 |
| 118 | Emil Sitko | 1950 | 1950 | 8 | 1 | 23 | 105 | 1 | 15 | 4.6 | 13.1 | 1 |
| 119 | Ken Casanega | 1946 | 1946 | 14 | 0 | 29 | 90 | 1 | 0 | 3.1 | 6.4 | 0 |
| Rushing | ||||||||||||
| Rk | From | To | G | AV | Att | Yds | TD | Lng | Fmb | |||
| 120 | Ricky Ervins | 1995 | 1995 | 14 | 1 | 23 | 88 | 0 | 13 | 3.8 | 6.3 | 0 |
| 121 | Bryan Gilmore | 2006 | 2007 | 26 | 3 | 8 | 86 | 0 | 22 | 10.8 | 3.3 | 1 |
| 122 | Dick Renfro | 1946 | 1946 | 3 | 0 | 18 | 85 | 3 | 0 | 4.7 | 28.3 | 0 |
| 123 | Tommy Davis | 1965 | 1969 | 35 | 0 | 6 | 85 | 0 | 22 | 14.2 | 2.4 | 0 |
| 124 | Jim Monachino | 1951 | 1953 | 13 | 3 | 25 | 84 | 2 | 7 | 3.4 | 6.5 | 3 |
| 125 | Steve Bono | 1991 | 1993 | 33 | 11 | 44 | 83 | 1 | 19 | 1.9 | 2.5 | 9 |
| 126 | Mike Varajon | 1987 | 1987 | 3 | 1 | 18 | 82 | 0 | 11 | 4.6 | 27.3 | 0 |
| 127 | John Isenbarger | 1970 | 1973 | 55 | 5 | 27 | 80 | 0 | 27 | 3.0 | 1.5 | 0 |
| 128 | Ted Ginn Jr. | 2010 | 2011 | 13 | 2 | 10 | 79 | 0 | 24 | 7.9 | 6.1 | 1 |
| 129 | Larry Barnes | 1957 | 1957 | 10 | 2 | 20 | 78 | 0 | 16 | 3.9 | 7.8 | 2 |
| 130 | Josh Morgan | 2009 | 2010 | 32 | 10 | 7 | 78 | 0 | 20 | 11.1 | 2.4 | 2 |
| 131 | Arnaz Battle | 2003 | 2008 | 73 | 19 | 22 | 77 | 1 | 18 | 3.5 | 1.1 | 9 |
| 132 | Wally Yonamine | 1947 | 1947 | 12 | 0 | 19 | 74 | 0 | 0 | 3.9 | 6.2 | 0 |
| 133 | Alyn Beals | 1946 | 1949 | 39 | 0 | 11 | 73 | 0 | 0 | 6.6 | 1.9 | 0 |
| 134 | J.R. Boone | 1952 | 1952 | 12 | 6 | 24 | 72 | 0 | 12 | 3.0 | 6.0 | 1 |
| 135 | Tim Rattay | 2000 | 2005 | 32 | 11 | 39 | 69 | 0 | 15 | 1.8 | 2.2 | 17 |
| 136 | Fred Gehrke | 1950 | 1950 | 4 | 1 | 22 | 69 | 1 | 12 | 3.1 | 17.3 | 2 |
| 137 | Vince Williams | 1982 | 1982 | 2 | 1 | 20 | 68 | 0 | 12 | 3.4 | 34.0 | 0 |
| 138 | Bob Windsor | 1967 | 1971 | 41 | 14 | 7 | 67 | 0 | 21 | 9.6 | 1.6 | 2 |
| 139 | Bob White | 1951 | 1952 | 24 | 2 | 32 | 66 | 1 | 17 | 2.1 | 2.8 | 1 |
| 140 | Moran Norris | 2006 | 2010 | 62 | 7 | 26 | 66 | 1 | 15 | 2.5 | 1.1 | 1 |
| 141 | Tom Wittum | 1973 | 1975 | 42 | 0 | 3 | 66 | 0 | 63 | 22.0 | 1.6 | 1 |
| 142 | Paul Crowe | 1948 | 1949 | 16 | 0 | 14 | 65 | 0 | 0 | 4.6 | 4.1 | 0 |
| 143 | Carl Monroe | 1983 | 1987 | 24 | 4 | 15 | 62 | 0 | 17 | 4.1 | 2.6 | 3 |
| 144 | Lamar McHan | 1963 | 1963 | 11 | 4 | 17 | 59 | 0 | 16 | 3.5 | 5.4 | 3 |
| 145 | Bud Laughlin | 1955 | 1955 | 10 | 1 | 20 | 58 | 0 | 14 | 2.9 | 5.8 | 4 |
| 146 | Rudy Johnson | 1964 | 1965 | 19 | 2 | 22 | 57 | 1 | 24 | 2.6 | 3.0 | 2 |
| 147 | Elvis Grbac | 1994 | 1996 | 43 | 11 | 56 | 55 | 4 | 12 | 1.0 | 1.3 | 7 |
| 148 | Amos Lawrence | 1981 | 1982 | 21 | 1 | 18 | 55 | 1 | 14 | 3.1 | 2.6 | 4 |
| 149 | Norm Snead | 1974 | 1975 | 12 | 6 | 10 | 55 | 1 | 25 | 5.5 | 4.6 | 5 |
| Rushing | ||||||||||||
| Rk | From | To | G | AV | Att | Yds | TD | Lng | Fmb | |||
| 150 | Jeff Brohm | 1996 | 1997 | 8 | 2 | 20 | 54 | 0 | 22 | 2.7 | 6.8 | 4 |
| 151 | Dwight Clark | 1981 | 1983 | 32 | 19 | 6 | 50 | 0 | 18 | 8.3 | 1.6 | 0 |
| 152 | Jeff Kemp | 1986 | 1986 | 10 | 5 | 15 | 49 | 0 | 12 | 3.3 | 4.9 | 3 |
| 153 | Travis Jervey | 1999 | 2000 | 16 | 0 | 7 | 49 | 1 | 33 | 7.0 | 3.1 | 0 |
| 154 | Andre Hardy | 1987 | 1987 | 1 | 1 | 7 | 48 | 0 | 14 | 6.9 | 48.0 | 0 |
| 155 | Cody Pickett | 2004 | 2005 | 7 | 1 | 14 | 47 | 0 | 12 | 3.4 | 6.7 | 4 |
| 156 | Del Rodgers | 1987 | 1987 | 7 | 1 | 11 | 46 | 1 | 15 | 4.2 | 6.6 | 1 |
| 157 | Mark Stevens | 1987 | 1987 | 2 | 1 | 10 | 45 | 1 | 16 | 4.5 | 22.5 | 0 |
| 158 | Delanie Walker | 2008 | 2011 | 45 | 6 | 11 | 44 | 0 | 16 | 4.0 | 1.0 | 6 |
| 159 | Spencer Tillman | 1991 | 1991 | 16 | 0 | 13 | 40 | 0 | 8 | 3.1 | 2.5 | 2 |
| 160 | Abe Woodson | 1958 | 1961 | 35 | 33 | 20 | 39 | 0 | 14 | 2.0 | 1.1 | 5 |
| 161 | Tom Orosz | 1983 | 1983 | 16 | 0 | 2 | 39 | 0 | 23 | 19.5 | 2.4 | 1 |
| 162 | Tom Owen | 1974 | 1975 | 14 | 6 | 17 | 37 | 1 | 7 | 2.2 | 2.6 | 5 |
| 163 | Carroll Hardy | 1955 | 1955 | 10 | 1 | 15 | 37 | 0 | 14 | 2.5 | 3.7 | 2 |
| 164 | Clem Daniels | 1968 | 1968 | 9 | 1 | 12 | 37 | 0 | 11 | 3.1 | 4.1 | 0 |
| 165 | Bennie Aldridge | 1952 | 1952 | 11 | 2 | 13 | 36 | 0 | 11 | 2.8 | 3.3 | 1 |
| 166 | Jamal Willis | 1995 | 1995 | 11 | 0 | 12 | 35 | 0 | 15 | 2.9 | 3.2 | 0 |
| 167 | Steve DeBerg | 1978 | 1980 | 39 | 18 | 38 | 34 | 1 | 8 | 0.9 | 0.9 | 19 |
| 168 | Manfred Moore | 1974 | 1975 | 28 | 1 | 13 | 34 | 1 | 8 | 2.6 | 1.2 | 6 |
| 169 | James Owens | 1979 | 1979 | 16 | 2 | 7 | 33 | 0 | 11 | 4.7 | 2.1 | 4 |
| 170 | Kyle Williams | 2011 | 2011 | 2 | 32 | 0 | 25 | 16.0 | 2 | |||
| 171 | Parker Hall | 1946 | 1946 | 11 | 0 | 17 | 31 | 0 | 0 | 1.8 | 2.8 | 0 |
| 172 | Mike Hogan | 1979 | 1979 | 2 | 1 | 9 | 31 | 0 | 6 | 3.4 | 15.5 | 0 |
| 173 | John Taylor | 1989 | 1994 | 55 | 39 | 6 | 31 | 0 | 12 | 5.2 | 0.6 | 5 |
| 174 | Don McIlhenny | 1961 | 1961 | 5 | 0 | 8 | 30 | 0 | 15 | 3.8 | 6.0 | 0 |
| 175 | Lenny Lyles | 1959 | 1959 | 12 | 1 | 13 | 28 | 1 | 13 | 2.2 | 2.3 | 1 |
| 176 | Lem Harkey | 1955 | 1955 | 4 | 1 | 6 | 27 | 0 | 15 | 4.5 | 6.8 | 0 |
| 177 | Lowell Wagner | 1949 | 1953 | 32 | 14 | 6 | 26 | 0 | 4 | 4.3 | 0.8 | 1 |
| 178 | Trent Dilfer | 2007 | 2007 | 7 | -1 | 10 | 25 | 0 | 11 | 2.5 | 3.6 | 8 |
| 179 | Dave Williams | 1977 | 1978 | 28 | 3 | 17 | 24 | 0 | 6 | 1.4 | 0.9 | 6 |
| Rushing | ||||||||||||
| Rk | From | To | G | AV | Att | Yds | TD | Lng | Fmb | |||
| 180 | Bernie Casey | 1966 | 1966 | 13 | 6 | 1 | 23 | 0 | 23 | 23.0 | 1.8 | 1 |
| 181 | Mike Moroski | 1986 | 1986 | 15 | 2 | 6 | 22 | 1 | 12 | 3.7 | 1.5 | 3 |
| 182 | Dave Atkins | 1973 | 1973 | 5 | 0 | 4 | 19 | 1 | 8 | 4.8 | 3.8 | 0 |
| 183 | Mike Shumann | 1979 | 1979 | 16 | 4 | 1 | 19 | 0 | 19 | 19.0 | 1.2 | 0 |
| 184 | J.W. Lockett | 1961 | 1961 | 2 | 1 | 11 | 18 | 1 | 9 | 1.6 | 9.0 | 1 |
| 185 | Ken Dorsey | 2004 | 2005 | 12 | 1 | 9 | 18 | 0 | 6 | 2.0 | 1.5 | 7 |
| 186 | Ed Robnett | 1947 | 1947 | 4 | 0 | 7 | 18 | 0 | 0 | 2.6 | 4.5 | 0 |
| 187 | Marty Domres | 1976 | 1976 | 5 | 1 | 4 | 18 | 0 | 8 | 4.5 | 3.6 | 0 |
| 188 | Frank Cassara | 1954 | 1954 | 6 | 1 | 3 | 17 | 0 | 10 | 5.7 | 2.8 | 1 |
| 189 | Ken Roskie | 1946 | 1946 | 8 | 0 | 9 | 16 | 0 | 0 | 1.8 | 2.0 | 0 |
| 190 | Vinny Sutherland | 2001 | 2001 | 15 | 0 | 1 | 16 | 0 | 16 | 16.0 | 1.1 | 1 |
| 191 | Bill Cooper | 1961 | 1962 | 22 | 2 | 10 | 15 | 1 | 6 | 1.5 | 0.7 | 0 |
| 192 | Kenny Harrison | 1977 | 1977 | 14 | 3 | 6 | 15 | 0 | 15 | 2.5 | 1.1 | 4 |
| 193 | Steve Stenstrom | 1999 | 1999 | 6 | 2 | 3 | 15 | 0 | 8 | 5.0 | 2.5 | 3 |
| 194 | Dale Messer | 1961 | 1961 | 4 | 0 | 3 | 13 | 0 | 6 | 4.3 | 3.3 | 0 |
| 195 | Vernon Davis | 2006 | 2011 | 26 | 9 | 5 | 11 | 0 | 11 | 2.2 | 0.4 | 6 |
| 196 | Randy Jackson | 1973 | 1973 | 2 | 0 | 6 | 10 | 0 | 5 | 1.7 | 5.0 | 0 |
| 197 | Earl Morrall | 1956 | 1956 | 12 | 1 | 6 | 10 | 0 | 8 | 1.7 | 0.8 | 1 |
| 198 | Willie McGee | 1976 | 1977 | 13 | 3 | 4 | 9 | 0 | 19 | 2.3 | 0.7 | 0 |
| 199 | Bruce Miller | 2011 | 2011 | 4 | 8 | 0 | 3 | 2.0 | 1 | |||
| 200 | Ty Detmer | 1998 | 1998 | 16 | 1 | 8 | 7 | 0 | 10 | 0.9 | 0.4 | 1 |
| 201 | Jim Jackson | 1966 | 1966 | 10 | 1 | 4 | 7 | 0 | 4 | 1.8 | 0.7 | 1 |
| 202 | Rex Berry | 1952 | 1952 | 12 | 9 | 1 | 7 | 0 | 7 | 7.0 | 0.6 | 0 |
| 203 | Michael Crabtree | 2011 | 2011 | 1 | 6 | 0 | 6 | 6.0 | 0 | |||
| 204 | Jonas Lewis | 2000 | 2000 | 10 | 1 | 1 | 6 | 0 | 6 | 6.0 | 0.6 | 0 |
| 205 | J.J. Stokes | 2000 | 2000 | 16 | 6 | 1 | 6 | 0 | 6 | 6.0 | 0.4 | 0 |
| 206 | Royal Cathcart | 1950 | 1950 | 2 | 1 | 3 | 5 | 0 | 3 | 1.7 | 2.5 | 6 |
| 207 | Jim Lash | 1976 | 1976 | 8 | 2 | 3 | 5 | 0 | 8 | 1.7 | 0.6 | 0 |
| 208 | Jason Hill | 2008 | 2008 | 16 | 3 | 2 | 5 | 0 | 9 | 2.5 | 0.3 | 1 |
| 209 | Billy Atkins | 1958 | 1958 | 12 | 1 | 1 | 5 | 0 | 5 | 5.0 | 0.4 | 0 |
| Rushing | ||||||||||||
| Rk | From | To | G | AV | Att | Yds | TD | Lng | Fmb | |||
| 210 | Leo Nomellini | 1952 | 1952 | 12 | 13 | 1 | 5 | 0 | 5 | 5.0 | 0.4 | 1 |
| 211 | Bev Wallace | 1948 | 1949 | 19 | 0 | 5 | 4 | 1 | 0 | 0.8 | 0.2 | 0 |
| 212 | Zak Keasey | 2007 | 2007 | 13 | 1 | 2 | 4 | 0 | 3 | 2.0 | 0.3 | 0 |
| 213 | Tom McCormick | 1956 | 1956 | 6 | 1 | 2 | 4 | 0 | 2 | 2.0 | 0.7 | 0 |
| 214 | Gene Moore | 1969 | 1969 | 5 | 0 | 2 | 4 | 0 | 2 | 2.0 | 0.8 | 0 |
| 215 | Jim Strong | 1970 | 1970 | 3 | 0 | 2 | 3 | 0 | 3 | 1.5 | 1.0 | 0 |
| 216 | Chris Hetherington | 2005 | 2005 | 16 | 1 | 1 | 3 | 0 | 3 | 3.0 | 0.2 | 0 |
| 217 | Hal Ledyard | 1953 | 1953 | 10 | 2 | 1 | 3 | 0 | 3 | 3.0 | 0.3 | 0 |
| 218 | Micheal Spurlock | 2009 | 2009 | 4 | 0 | 1 | 3 | 0 | 3 | 3.0 | 0.8 | 1 |
| 219 | Matt Cavanaugh | 1983 | 1985 | 29 | 3 | 9 | 2 | 0 | 13 | 0.2 | 0.1 | 0 |
| 220 | Terry Beasley | 1974 | 1975 | 21 | 6 | 2 | 2 | 0 | 5 | 1.0 | 0.1 | 1 |
| 221 | Guy Benjamin | 1981 | 1983 | 8 | 1 | 2 | 2 | 0 | 1 | 1.0 | 0.3 | 1 |
| 222 | Cedrick Wilson | 2003 | 2004 | 31 | 9 | 2 | 2 | 0 | 6 | 1.0 | 0.1 | 1 |
| 223 | Earl Carr | 1978 | 1978 | 14 | 0 | 1 | 2 | 0 | 2 | 2.0 | 0.1 | 0 |
| 224 | Arnie Galiffa | 1954 | 1954 | 4 | 1 | 1 | 2 | 0 | 2 | 2.0 | 0.5 | 0 |
| 225 | Bob Meyers | 1952 | 1952 | 1 | 1 | 1 | 2 | 0 | 2 | 2.0 | 2.0 | 0 |
| 226 | Bob Titchenal | 1946 | 1946 | 14 | 0 | 1 | 2 | 0 | 2 | 2.0 | 0.1 | 0 |
| 227 | Eason Ramson | 1980 | 1983 | 32 | 6 | 3 | 1 | 0 | 4 | 0.3 | 0.0 | 2 |
| 228 | Dwight Lee | 1968 | 1968 | 2 | 0 | 2 | 1 | 0 | 1 | 0.5 | 0.5 | 0 |
| 229 | Ken Bahnsen | 1953 | 1953 | 7 | 2 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| 230 | Gail Bruce | 1948 | 1948 | 14 | 0 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| 231 | Allen Rossum | 2008 | 2008 | 13 | 2 | 1 | 1 | 1 | 1 | 1.0 | 0.1 | 0 |
| 232 | Hal Shoener | 1950 | 1950 | 12 | 7 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 0 |
| 233 | Billy Tidwell | 1954 | 1954 | 10 | 1 | 1 | 1 | 0 | 1 | 1.0 | 0.1 | 1 |
| 234 | Ray Norton | 1960 | 1961 | 9 | 0 | 4 | 0 | 0 | 9 | 0.0 | 0.0 | 1 |
| 235 | Klaus Wilmsmeyer | 1992 | 1993 | 30 | 0 | 4 | 0 | 0 | 10 | 0.0 | 0.0 | 3 |
| 236 | Dan Melville | 1979 | 1979 | 16 | 0 | 3 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 237 | Rick Mirer | 2000 | 2000 | 1 | 0 | 3 | 0 | 0 | 3 | 0.0 | 0.0 | 0 |
| 238 | Barry Helton | 1988 | 1989 | 31 | 0 | 2 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 239 | Jason Baker | 2001 | 2001 | 16 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| Rushing | ||||||||||||
| Rk | From | To | G | AV | Att | Yds | TD | Lng | Fmb | |||
| 240 | Ed Blount | 1987 | 1987 | 1 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 241 | Bruce Elia | 1978 | 1978 | 16 | 1 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 242 | Jasen Isom | 2004 | 2004 | 5 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 243 | Bill LaFleur | 2003 | 2003 | 16 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 244 | Dennis Morrison | 1974 | 1974 | 3 | 1 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 245 | R.C. Owens | 1959 | 1959 | 12 | 1 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 246 | Reggie Roby | 1998 | 1998 | 14 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 247 | Chad Stanley | 1999 | 1999 | 16 | 0 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 0 |
| 248 | Tai Streets | 2000 | 2000 | 15 | 3 | 1 | 0 | 0 | 0 | 0.0 | 0.0 | 1 |
| 249 | Gene A. Washington | 1969 | 1976 | 56 | 27 | 5 | -1 | 0 | 7 | -0.2 | 0.0 | 1 |
| 250 | John Frank | 1986 | 1987 | 28 | 8 | 2 | -1 | 0 | 2 | -0.5 | 0.0 | 2 |
| 251 | Clifton McNeil | 1968 | 1968 | 14 | 11 | 1 | -1 | 0 | -1 | -1.0 | -0.1 | 1 |
| 252 | Renaldo Nehemiah | 1982 | 1982 | 8 | 2 | 1 | -1 | 0 | -1 | -1.0 | -0.1 | 0 |
| 253 | Dave Parks | 1966 | 1966 | 13 | 9 | 1 | -1 | 0 | -1 | -1.0 | -0.1 | 0 |
| 254 | Bob Hayes | 1975 | 1975 | 4 | 1 | 2 | -2 | 0 | -1 | -1.0 | -0.5 | 0 |
| 255 | Colin Kaepernick | 2011 | 2011 | 2 | -2 | 0 | -1 | -1.0 | 0 | |||
| 256 | Tom Mitchell | 1974 | 1974 | 14 | 5 | 1 | -2 | 0 | -2 | -2.0 | -0.1 | 0 |
| 257 | Bill Musgrave | 1993 | 1993 | 1 | 0 | 3 | -3 | 0 | -1 | -1.0 | -3.0 | 0 |
| 258 | Bob Bruer | 1979 | 1979 | 16 | 4 | 5 | -4 | 0 | 6 | -0.8 | -0.3 | 1 |
| 259 | Mike Holmes | 1975 | 1975 | 14 | 5 | 1 | -4 | 0 | -4 | -4.0 | -0.3 | 1 |
| 260 | Gordie Soltau | 1951 | 1951 | 12 | 9 | 1 | -4 | 0 | -4 | -4.0 | -0.3 | 3 |
| 261 | Pete Franceschi | 1946 | 1946 | 9 | 0 | 8 | -5 | 1 | 0 | -0.6 | -0.6 | 0 |
| 262 | Maury Duncan | 1955 | 1955 | 11 | 1 | 1 | -5 | 0 | -5 | -5.0 | -0.5 | 1 |
| 263 | Bill Jessup | 1954 | 1954 | 12 | 4 | 1 | -5 | 0 | -5 | -5.0 | -0.4 | 2 |
| 264 | Max Runager | 1984 | 1984 | 14 | 0 | 1 | -5 | 0 | -5 | -5.0 | -0.4 | 0 |
| 265 | Jim Powers | 1950 | 1953 | 22 | 9 | 6 | -6 | 0 | 3 | -1.0 | -0.3 | 1 |
| 266 | Pete Brown | 1954 | 1954 | 12 | 1 | 1 | -6 | 0 | -6 | -6.0 | -0.5 | 0 |
| 267 | Rasheed Marshall | 2005 | 2005 | 12 | 0 | 1 | -7 | 0 | -7 | -7.0 | -0.6 | 4 |
| 268 | Taylor Jacobs | 2007 | 2007 | 4 | 0 | 1 | -8 | 0 | -8 | -8.0 | -2.0 | 0 |
| 269 | Larry Jones | 1978 | 1978 | 9 | 0 | 1 | -9 | 0 | -9 | -9.0 | -1.0 | 1 |
| Rushing | ||||||||||||
| Rk | From | To | G | AV | Att | Yds | TD | Lng | Fmb | |||
| 270 | Jim Druckenmiller | 1997 | 1998 | 6 | 1 | 13 | -10 | 0 | 2 | -0.8 | -1.7 | 0 |
| 271 | Joe Prokop | 1991 | 1991 | 11 | 0 | 1 | -10 | 0 | -10 | -10.0 | -0.9 | 1 |
| 272 | Isaac Bruce | 2008 | 2009 | 26 | 9 | 2 | -11 | 0 | -3 | -5.5 | -0.4 | 0 |
| 273 | Jim Miller | 1980 | 1980 | 16 | 0 | 2 | -12 | 0 | 0 | -6.0 | -0.8 | 0 |
| 274 | Jim McCann | 1971 | 1971 | 13 | 0 | 2 | -15 | 0 | -6 | -7.5 | -1.2 | 3 |
| 275 | Andy Lee | 2011 | 2011 | 1 | -18 | 0 | -18 | -18.0 | 0 | |||
| 276 | Aaron Thomas | 1961 | 1962 | 16 | 5 | 2 | -24 | 0 | -9 | -12.0 | -1.5 | 1 |
| 277 | Jesse Freitas | 1946 | 1947 | 20 | 0 | 12 | -30 | 0 | 0 | -2.5 | -1.5 | 0 |