| Single-season | Passing | Rushing | Receiving | Returns | Kicking | Scoring | |
| Career | Passing | Rushing | Receiving | Returns | Kicking | Scoring | Defense |
| Rk | Year | Age | Tm | Pos | G | GS | Rec | Yds | TD | Lng | Fmb | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jerry Rice | 1995*+ | 33 | SFO | WR | 16 | 16 | 122 | 1848 | 15.1 | 15 | 81 | 7.6 | 115.5 | 3 |
| 2 | Jerry Rice | 1994*+ | 32 | SFO | WR | 16 | 16 | 112 | 1499 | 13.4 | 13 | 69 | 7.0 | 93.7 | 1 |
| 3 | Jerry Rice | 1996*+ | 34 | SFO | WR | 16 | 16 | 108 | 1254 | 11.6 | 8 | 39 | 6.8 | 78.4 | 0 |
| 4 | Terrell Owens | 2002*+ | 29 | SFO | WR | 14 | 14 | 100 | 1300 | 13.0 | 13 | 76 | 7.1 | 92.9 | 0 |
| 5 | Jerry Rice | 1990*+ | 28 | SFO | WR | 16 | 16 | 100 | 1502 | 15.0 | 13 | 64 | 6.3 | 93.9 | 1 |
| 6 | Jerry Rice | 1993*+ | 31 | SFO | WR | 16 | 16 | 98 | 1503 | 15.3 | 15 | 80 | 6.1 | 93.9 | 3 |
| 7 | Terrell Owens | 2000*+ | 27 | SFO | WR | 14 | 13 | 97 | 1451 | 15.0 | 13 | 69 | 6.9 | 103.6 | 3 |
| 8 | Terrell Owens | 2001*+ | 28 | SFO | WR | 16 | 16 | 93 | 1412 | 15.2 | 16 | 60 | 5.8 | 88.3 | 0 |
| 9 | Roger Craig | 1985* | 25 | SFO | FB | 16 | 16 | 92 | 1016 | 11.0 | 6 | 73 | 5.8 | 63.5 | 5 |
| 10 | Derek Loville | 1995 | 27 | SFO | RB | 16 | 16 | 87 | 662 | 7.6 | 3 | 31 | 5.4 | 41.4 | 1 |
| 11 | Jerry Rice | 1986*+ | 24 | SFO | WR | 16 | 15 | 86 | 1570 | 18.3 | 15 | 66 | 5.4 | 98.1 | 2 |
| 12 | Dwight Clark | 1981* | 24 | SFO | WR | 16 | 16 | 85 | 1105 | 13.0 | 4 | 78 | 5.3 | 69.1 | 0 |
| 13 | Jerry Rice | 1992*+ | 30 | SFO | WR | 16 | 16 | 84 | 1201 | 14.3 | 10 | 80 | 5.3 | 75.1 | 2 |
| 14 | Earl Cooper | 1980 | 23 | SFO | FB | 16 | 16 | 83 | 567 | 6.8 | 4 | 66 | 5.2 | 35.4 | 8 |
| 15 | Dwight Clark | 1980 | 23 | SFO | WR | 16 | 12 | 82 | 991 | 12.1 | 8 | 71 | 5.1 | 61.9 | 2 |
| 16 | Eric Johnson | 2004 | 25 | SFO | TE | 16 | 14 | 82 | 825 | 10.1 | 2 | 25 | 5.1 | 51.6 | 1 |
| 17 | Jerry Rice | 1998* | 36 | SFO | WR | 16 | 16 | 82 | 1157 | 14.1 | 9 | 75 | 5.1 | 72.3 | 2 |
| 18 | Jerry Rice | 1989*+ | 27 | SFO | WR | 16 | 16 | 82 | 1483 | 18.1 | 17 | 68 | 5.1 | 92.7 | 0 |
| 19 | Roger Craig | 1986 | 26 | SFO | FB | 16 | 15 | 81 | 624 | 7.7 | 0 | 48 | 5.1 | 39.0 | 4 |
| 20 | Terrell Owens | 2003* | 30 | SFO | WR | 15 | 15 | 80 | 1102 | 13.8 | 9 | 75 | 5.3 | 73.5 | 0 |
| 21 | Dave Parks | 1965*+ | 24 | SFO | SE | 14 | 14 | 80 | 1344 | 16.8 | 12 | 53 | 5.7 | 96.0 | 1 |
| 22 | Jerry Rice | 1991* | 29 | SFO | WR | 16 | 16 | 80 | 1206 | 15.1 | 14 | 73 | 5.0 | 75.4 | 1 |
| 23 | Roger Craig | 1988*+ | 28 | SFO | RB | 16 | 15 | 76 | 534 | 7.0 | 1 | 22 | 4.8 | 33.4 | 8 |
| 24 | Jerry Rice | 2000 | 38 | SFO | WR | 16 | 16 | 75 | 805 | 10.7 | 7 | 68 | 4.7 | 50.3 | 3 |
| 25 | Tom Rathman | 1989 | 27 | SFO | FB | 16 | 16 | 73 | 616 | 8.4 | 1 | 36 | 4.6 | 38.5 | 1 |
| 26 | Tai Streets | 2002 | 25 | SFO | WR | 16 | 14 | 72 | 756 | 10.5 | 5 | 47 | 4.5 | 47.3 | 1 |
| 27 | Roger Craig | 1984 | 24 | SFO | FB | 16 | 16 | 71 | 675 | 9.5 | 3 | 64 | 4.4 | 42.2 | 3 |
| 28 | Clifton McNeil | 1968*+ | 28 | SFO | FL | 14 | 14 | 71 | 994 | 14.0 | 7 | 65 | 5.1 | 71.0 | 1 |
| 29 | Dwight Clark | 1983 | 26 | SFO | WR | 16 | 13 | 70 | 840 | 12.0 | 8 | 46 | 4.4 | 52.5 | 0 |
| Rk | Year | Age | Tm | Pos | G | GS | Rec | Yds | TD | Lng | Fmb | ||||
| 30 | Charlie Garner | 2000* | 28 | SFO | RB | 16 | 15 | 68 | 647 | 9.5 | 3 | 62 | 4.3 | 40.4 | 4 |
| 31 | Brent Jones | 1993* | 30 | SFO | TE | 16 | 16 | 68 | 735 | 10.8 | 3 | 29 | 4.3 | 45.9 | 2 |
| 32 | Terrell Owens | 1998 | 25 | SFO | wr | 16 | 10 | 67 | 1097 | 16.4 | 14 | 79 | 4.2 | 68.6 | 1 |
| 33 | Jerry Rice | 1999 | 37 | SFO | WR | 16 | 16 | 67 | 830 | 12.4 | 5 | 62 | 4.2 | 51.9 | 0 |
| 34 | Roger Craig | 1987* | 27 | SFO | RB/fb | 14 | 14 | 66 | 492 | 7.5 | 1 | 35 | 4.7 | 35.1 | 5 |
| 35 | Dave Parks | 1966* | 25 | SFO | SE | 13 | 13 | 66 | 974 | 14.8 | 5 | 65 | 5.1 | 74.9 | 0 |
| 36 | Ricky Watters | 1994* | 25 | SFO | RB | 16 | 16 | 66 | 719 | 10.9 | 5 | 65 | 4.1 | 44.9 | 8 |
| 37 | Jerry Rice | 1987*+ | 25 | SFO | WR | 12 | 12 | 65 | 1078 | 16.6 | 22 | 57 | 5.4 | 89.8 | 2 |
| 38 | Jerry Rice | 1988*+ | 26 | SFO | WR | 16 | 16 | 64 | 1306 | 20.4 | 9 | 96 | 4.0 | 81.6 | 2 |
| 39 | John Taylor | 1991 | 29 | SFO | WR | 16 | 16 | 64 | 1011 | 15.8 | 9 | 97 | 4.0 | 63.2 | 1 |
| 40 | J.J. Stokes | 1998 | 26 | SFO | WR | 16 | 11 | 63 | 770 | 12.2 | 8 | 33 | 3.9 | 48.1 | 0 |
| 41 | Dwight Clark | 1986 | 29 | SFO | WR | 16 | 14 | 61 | 794 | 13.0 | 2 | 45 | 3.8 | 49.6 | 0 |
| 42 | Frank Gore | 2006* | 23 | SFO | RB | 16 | 16 | 61 | 485 | 8.0 | 1 | 39 | 3.8 | 30.3 | 6 |
| 43 | Dwight Clark | 1982*+ | 25 | SFO | WR | 9 | 8 | 60 | 913 | 15.2 | 5 | 51 | 6.7 | 101.4 | 1 |
| 44 | Brent Jones | 1995* | 32 | SFO | TE | 16 | 16 | 60 | 595 | 9.9 | 3 | 39 | 3.8 | 37.2 | 3 |
| 45 | Terrell Owens | 1997 | 24 | SFO | WR | 16 | 15 | 60 | 936 | 15.6 | 8 | 56 | 3.8 | 58.5 | 1 |
| 46 | Terrell Owens | 1999 | 26 | SFO | WR | 14 | 14 | 60 | 754 | 12.6 | 4 | 36 | 4.3 | 53.9 | 1 |
| 47 | John Taylor | 1989* | 27 | SFO | WR | 15 | 15 | 60 | 1077 | 18.0 | 10 | 95 | 4.0 | 71.8 | 3 |
| 48 | Billy Wilson | 1956* | 29 | SFO | RE | 12 | 0 | 60 | 889 | 14.8 | 5 | 77 | 5.0 | 74.1 | 1 |
| 49 | Billy Wilson | 1954* | 27 | SFO | RE | 12 | 0 | 60 | 830 | 13.8 | 5 | 43 | 5.0 | 69.2 | 1 |
| 50 | Arnaz Battle | 2006 | 26 | SFO | WR | 16 | 15 | 59 | 686 | 11.6 | 3 | 56 | 3.7 | 42.9 | 2 |
| 51 | Bernie Casey | 1965 | 26 | SFO | RH | 14 | 14 | 59 | 765 | 13.0 | 8 | 59 | 4.2 | 54.6 | 0 |
| 52 | Freddie Solomon | 1981 | 28 | SFO | WR | 15 | 15 | 59 | 969 | 16.4 | 8 | 60 | 3.9 | 64.6 | 3 |
| 53 | Gordie Soltau | 1951* | 26 | SFO | LE | 12 | 0 | 59 | 826 | 14.0 | 7 | 48 | 4.9 | 68.8 | 3 |
| 54 | Bernie Casey | 1964 | 25 | SFO | RH/lh | 13 | 13 | 58 | 808 | 13.9 | 4 | 63 | 4.5 | 62.2 | 0 |
| 55 | Paul Hofer | 1979 | 27 | SFO | rb | 15 | 7 | 58 | 662 | 11.4 | 2 | 44 | 3.9 | 44.1 | 3 |
| 56 | J.J. Stokes | 1997 | 25 | SFO | WR | 16 | 16 | 58 | 733 | 12.6 | 4 | 36 | 3.6 | 45.8 | 1 |
| 57 | Freddie Solomon | 1979 | 26 | SFO | WR | 15 | 12 | 57 | 807 | 14.2 | 7 | 44 | 3.8 | 53.8 | 3 |
| 58 | Charlie Garner | 1999 | 27 | SFO | RB | 16 | 15 | 56 | 535 | 9.6 | 2 | 53 | 3.5 | 33.4 | 4 |
| 59 | Brent Jones | 1990 | 27 | SFO | TE | 16 | 16 | 56 | 747 | 13.3 | 5 | 67 | 3.5 | 46.7 | 2 |
| Rk | Year | Age | Tm | Pos | G | GS | Rec | Yds | TD | Lng | Fmb | ||||
| 60 | John Taylor | 1993 | 31 | SFO | WR | 16 | 16 | 56 | 940 | 16.8 | 5 | 76 | 3.5 | 58.8 | 1 |
| 61 | R.C. Owens | 1961 | 28 | SFO | RH | 14 | 14 | 55 | 1032 | 18.8 | 5 | 54 | 3.9 | 73.7 | 1 |
| 62 | Gordie Soltau | 1952*+ | 27 | SFO | LE | 12 | 0 | 55 | 774 | 14.1 | 7 | 49 | 4.6 | 64.5 | 1 |
| 63 | Dwight Clark | 1985 | 28 | SFO | WR | 16 | 14 | 54 | 705 | 13.1 | 10 | 49 | 3.4 | 44.1 | 0 |
| 64 | J.J. Stokes | 2001 | 29 | SFO | WR | 16 | 16 | 54 | 585 | 10.8 | 7 | 47 | 3.4 | 36.6 | 0 |
| 65 | Bernie Casey | 1962 | 23 | SFO | RH/te | 13 | 11 | 53 | 819 | 15.5 | 6 | 48 | 4.1 | 63.0 | 1 |
| 66 | Frank Gore | 2007 | 24 | SFO | RB | 15 | 15 | 53 | 436 | 8.2 | 1 | 23 | 3.5 | 29.1 | 4 |
| 67 | Wilbur Jackson | 1979 | 28 | SFO | FB | 16 | 14 | 53 | 422 | 8.0 | 0 | 34 | 3.3 | 26.4 | 6 |
| 68 | Gene A. Washington | 1970*+ | 23 | SFO | WR | 13 | 0 | 53 | 1100 | 20.8 | 12 | 79 | 4.1 | 84.6 | 0 |
| 69 | Billy Wilson | 1955* | 28 | SFO | RE | 12 | 0 | 53 | 831 | 15.7 | 7 | 72 | 4.4 | 69.3 | 0 |
| 70 | Dwight Clark | 1984 | 27 | SFO | WR | 16 | 14 | 52 | 880 | 16.9 | 6 | 80 | 3.3 | 55.0 | 0 |
| 71 | Vernon Davis | 2007 | 23 | SFO | TE | 14 | 14 | 52 | 509 | 9.8 | 4 | 31 | 3.7 | 36.4 | 1 |
| 72 | Terry Kirby | 1996 | 26 | SFO | RB | 14 | 10 | 52 | 439 | 8.4 | 1 | 52 | 3.7 | 31.4 | 1 |
| 73 | Ted Kwalick | 1971* | 24 | SFO | TE | 14 | 14 | 52 | 664 | 12.8 | 5 | 42 | 3.7 | 47.4 | 2 |
| 74 | Billy Wilson | 1957*+ | 30 | SFO | RE | 11 | 0 | 52 | 757 | 14.6 | 6 | 40 | 4.7 | 68.8 | 0 |
| 75 | Earl Cooper | 1981 | 24 | SFO | FB | 16 | 11 | 51 | 477 | 9.4 | 0 | 50 | 3.2 | 29.8 | 3 |
| 76 | Doug Cunningham | 1969 | 24 | SFO | HB | 14 | 13 | 51 | 484 | 9.5 | 0 | 58 | 3.6 | 34.6 | 5 |
| 77 | Gene A. Washington | 1969*+ | 22 | SFO | SE | 14 | 14 | 51 | 711 | 13.9 | 3 | 52 | 3.6 | 50.8 | 0 |
| 78 | Billy Wilson | 1953 | 26 | SFO | RE | 12 | 0 | 51 | 840 | 16.5 | 10 | 61 | 4.3 | 70.0 | 1 |
| 79 | Arnaz Battle | 2007 | 27 | SFO | WR | 16 | 15 | 50 | 600 | 12.0 | 5 | 57 | 3.1 | 37.5 | 3 |
| 80 | Bernie Casey | 1966 | 27 | SFO | FL | 13 | 13 | 50 | 669 | 13.4 | 1 | 32 | 3.8 | 51.5 | 1 |
| 81 | Clyde Conner | 1958 | 25 | SFO | LE | 12 | 0 | 49 | 512 | 10.4 | 5 | 26 | 4.1 | 42.7 | 1 |
| 82 | Roger Craig | 1989* | 29 | SFO | RB | 16 | 16 | 49 | 473 | 9.7 | 1 | 44 | 3.1 | 29.6 | 4 |
| 83 | Brent Jones | 1994* | 31 | SFO | TE | 15 | 15 | 49 | 670 | 13.7 | 9 | 69 | 3.3 | 44.7 | 1 |
| 84 | Jerry Rice | 1985 | 23 | SFO | 16 | 4 | 49 | 927 | 18.9 | 3 | 66 | 3.1 | 57.9 | 1 | |
| 85 | John Taylor | 1990 | 28 | SFO | WR | 14 | 14 | 49 | 748 | 15.3 | 7 | 78 | 3.5 | 53.4 | 2 |
| 86 | Bob Windsor | 1969 | 27 | SFO | TE | 14 | 14 | 49 | 597 | 12.2 | 2 | 32 | 3.5 | 42.6 | 0 |
| 87 | Roger Craig | 1983 | 23 | SFO | FB | 16 | 13 | 48 | 427 | 8.9 | 4 | 23 | 3.0 | 26.7 | 6 |
| 88 | Garrison Hearst | 2002 | 31 | SFO | RB | 16 | 16 | 48 | 317 | 6.6 | 1 | 16 | 3.0 | 19.8 | 4 |
| 89 | Brandon Lloyd | 2005 | 24 | SFO | WR | 16 | 15 | 48 | 733 | 15.3 | 5 | 89 | 3.0 | 45.8 | 1 |
| Rk | Year | Age | Tm | Pos | G | GS | Rec | Yds | TD | Lng | Fmb | ||||
| 90 | Tom Rathman | 1990 | 28 | SFO | FB | 16 | 16 | 48 | 327 | 6.8 | 0 | 28 | 3.0 | 20.4 | 2 |
| 91 | Freddie Solomon | 1980 | 27 | SFO | WR | 16 | 13 | 48 | 658 | 13.7 | 8 | 93 | 3.0 | 41.1 | 5 |
| 92 | Alyn Beals | 1947 | 26 | SFO | RE | 13 | 9 | 47 | 655 | 13.9 | 10 | 54 | 3.6 | 50.4 | 0 |
| 93 | Bernie Casey | 1963 | 24 | SFO | RH | 14 | 10 | 47 | 762 | 16.2 | 7 | 68 | 3.4 | 54.4 | 0 |
| 94 | William Floyd | 1995 | 23 | SFO | FB | 8 | 8 | 47 | 348 | 7.4 | 1 | 23 | 5.9 | 43.5 | 1 |
| 95 | Ted Kwalick | 1973* | 26 | SFO | TE | 14 | 14 | 47 | 729 | 15.5 | 5 | 48 | 3.4 | 52.1 | 1 |
| 96 | Tai Streets | 2003 | 26 | SFO | WR | 16 | 16 | 47 | 595 | 12.7 | 7 | 41 | 2.9 | 37.2 | 0 |
| 97 | Cedrick Wilson | 2004 | 26 | SFO | WR | 15 | 15 | 47 | 641 | 13.6 | 3 | 39 | 3.1 | 42.7 | 0 |
| 98 | Alyn Beals | 1948 | 27 | SFO | RE | 14 | 13 | 46 | 591 | 12.8 | 14 | 0 | 3.3 | 42.2 | 0 |
| 99 | Darrell Jackson | 2007 | 29 | SFO | WR | 15 | 15 | 46 | 497 | 10.8 | 3 | 34 | 3.1 | 33.1 | 1 |
| 100 | Gene A. Washington | 1971* | 24 | SFO | WR | 14 | 14 | 46 | 884 | 19.2 | 4 | 71 | 3.3 | 63.1 | 0 |
| 101 | Gene A. Washington | 1972*+ | 25 | SFO | WR | 14 | 14 | 46 | 918 | 20.0 | 12 | 62 | 3.3 | 65.6 | 0 |
| 102 | Dick Witcher | 1967 | 23 | SFO | FL | 14 | 9 | 46 | 705 | 15.3 | 3 | 63 | 3.3 | 50.4 | 0 |
| 103 | Brent Jones | 1992* | 29 | SFO | TE | 15 | 15 | 45 | 628 | 14.0 | 4 | 43 | 3.0 | 41.9 | 1 |
| 104 | Alyn Beals | 1949 | 28 | SFO | RE | 12 | 8 | 44 | 678 | 15.4 | 12 | 0 | 3.7 | 56.5 | 0 |
| 105 | Russ Francis | 1985 | 32 | SFO | TE | 16 | 16 | 44 | 478 | 10.9 | 3 | 25 | 2.8 | 29.9 | 2 |
| 106 | Tom Rathman | 1992 | 30 | SFO | FB | 15 | 15 | 44 | 343 | 7.8 | 4 | 27 | 2.9 | 22.9 | 1 |
| 107 | Gene A. Washington | 1975 | 28 | SFO | WR | 14 | 14 | 44 | 735 | 16.7 | 9 | 68 | 3.1 | 52.5 | 1 |
| 108 | Billy Wilson | 1959* | 32 | SFO | RE | 10 | 0 | 44 | 540 | 12.3 | 4 | 57 | 4.4 | 54.0 | 0 |
| 109 | Brandon Lloyd | 2004 | 23 | SFO | WR | 13 | 13 | 43 | 565 | 13.1 | 6 | 52 | 3.3 | 43.5 | 0 |
| 110 | Gordie Soltau | 1953* | 28 | SFO | LE | 12 | 0 | 43 | 620 | 14.4 | 6 | 54 | 3.6 | 51.7 | 1 |
| 111 | Monty Stickles | 1961 | 23 | SFO | TE | 14 | 12 | 43 | 794 | 18.5 | 5 | 54 | 3.1 | 56.7 | 0 |
| 112 | Vic Washington | 1972 | 26 | SFO | RB | 13 | 13 | 43 | 393 | 9.1 | 1 | 33 | 3.3 | 30.2 | 7 |
| 113 | Ricky Watters | 1992* | 23 | SFO | RB | 14 | 13 | 43 | 405 | 9.4 | 2 | 35 | 3.1 | 28.9 | 2 |
| 114 | Billy Wilson | 1958* | 31 | SFO | RE | 9 | 0 | 43 | 592 | 13.8 | 5 | 44 | 4.8 | 65.8 | 0 |
| 115 | Tom Rathman | 1988 | 26 | SFO | FB | 16 | 16 | 42 | 382 | 9.1 | 0 | 24 | 2.6 | 23.9 | 0 |
| 116 | Ken Willard | 1966* | 23 | SFO | FB | 14 | 14 | 42 | 351 | 8.4 | 2 | 52 | 3.0 | 25.1 | 7 |
| 117 | Earl Cooper | 1984 | 27 | SFO | TE | 16 | 8 | 41 | 459 | 11.2 | 4 | 26 | 2.6 | 28.7 | 0 |
| 118 | Russ Francis | 1986 | 33 | SFO | TE | 16 | 14 | 41 | 505 | 12.3 | 1 | 52 | 2.6 | 31.6 | 0 |
| 119 | Garrison Hearst | 2001* | 30 | SFO | RB | 16 | 16 | 41 | 347 | 8.5 | 1 | 60 | 2.6 | 21.7 | 1 |
| Rk | Year | Age | Tm | Pos | G | GS | Rec | Yds | TD | Lng | Fmb | ||||
| 120 | Paul Hofer | 1980 | 28 | SFO | RB | 6 | 6 | 41 | 467 | 11.4 | 2 | 28 | 6.8 | 77.8 | 0 |
| 121 | John Taylor | 1994 | 32 | SFO | WR | 15 | 15 | 41 | 531 | 13.0 | 5 | 35 | 2.7 | 35.4 | 1 |
| 122 | Alyn Beals | 1946 | 25 | SFO | le | 14 | 1 | 40 | 586 | 14.7 | 10 | 0 | 2.9 | 41.9 | 0 |
| 123 | Antonio Bryant | 2006 | 25 | SFO | WR | 14 | 13 | 40 | 733 | 18.3 | 3 | 72 | 2.9 | 52.4 | 0 |
| 124 | Eric Johnson | 2001 | 22 | SFO | TE | 16 | 14 | 40 | 362 | 9.1 | 3 | 24 | 2.5 | 22.6 | 1 |
| 125 | Brent Jones | 1989 | 26 | SFO | TE | 16 | 16 | 40 | 500 | 12.5 | 4 | 36 | 2.5 | 31.3 | 0 |
| 126 | Ted Kwalick | 1972*+ | 25 | SFO | TE | 14 | 14 | 40 | 751 | 18.8 | 9 | 81 | 2.9 | 53.6 | 2 |
| 127 | R.C. Owens | 1958 | 25 | SFO | RH | 12 | 0 | 40 | 620 | 15.5 | 1 | 48 | 3.3 | 51.7 | 1 |
| 128 | Larry Schreiber | 1975 | 28 | SFO | FB | 14 | 14 | 40 | 289 | 7.2 | 1 | 20 | 2.9 | 20.6 | 6 |
| 129 | Freddie Solomon | 1984 | 31 | SFO | WR | 14 | 13 | 40 | 737 | 18.4 | 10 | 64 | 2.9 | 52.6 | 0 |
| 130 | Monty Stickles | 1964 | 26 | SFO | TE | 14 | 14 | 40 | 685 | 17.1 | 3 | 53 | 2.9 | 48.9 | 1 |
| 131 | Garrison Hearst | 1998* | 27 | SFO | RB | 16 | 16 | 39 | 535 | 13.7 | 2 | 81 | 2.4 | 33.4 | 4 |
| 132 | Mike Shumann | 1979 | 24 | SFO | WR | 16 | 14 | 39 | 452 | 11.6 | 4 | 39 | 2.4 | 28.3 | 0 |
| 133 | Dick Witcher | 1968 | 24 | SFO | SE | 14 | 13 | 39 | 531 | 13.6 | 1 | 59 | 2.8 | 37.9 | 1 |
| 134 | Greg Clark | 2000 | 28 | SFO | TE | 15 | 15 | 38 | 342 | 9.0 | 2 | 34 | 2.5 | 22.8 | 1 |
| 135 | Clyde Conner | 1960 | 27 | SFO | SE | 10 | 10 | 38 | 531 | 14.0 | 2 | 65 | 3.8 | 53.1 | 0 |
| 136 | Curtis Conway | 2004 | 33 | SFO | wr | 16 | 5 | 38 | 403 | 10.6 | 3 | 37 | 2.4 | 25.2 | 0 |
| 137 | Mike Sherrard | 1992 | 29 | SFO | wr | 16 | 8 | 38 | 607 | 16.0 | 0 | 56 | 2.4 | 37.9 | 1 |
| 138 | J.J. Stokes | 1995 | 23 | SFO | 12 | 2 | 38 | 517 | 13.6 | 4 | 41 | 3.2 | 43.1 | 0 | |
| 139 | William Floyd | 1997 | 25 | SFO | FB | 15 | 15 | 37 | 321 | 8.7 | 1 | 44 | 2.5 | 21.4 | 2 |
| 140 | Marc Logan | 1993 | 28 | SFO | FB | 14 | 12 | 37 | 348 | 9.4 | 0 | 24 | 2.6 | 24.9 | 2 |
| 141 | Hugh McElhenny | 1957* | 29 | SFO | LH | 12 | 0 | 37 | 458 | 12.4 | 2 | 43 | 3.1 | 38.2 | 8 |
| 142 | Jeff Moore | 1982 | 26 | SFO | RB | 9 | 4 | 37 | 405 | 10.9 | 4 | 55 | 4.1 | 45.0 | 4 |
| 143 | R.C. Owens | 1960 | 27 | SFO | RH | 12 | 10 | 37 | 532 | 14.4 | 6 | 42 | 3.1 | 44.3 | 1 |
| 144 | Gene A. Washington | 1973 | 26 | SFO | WR | 13 | 13 | 37 | 606 | 16.4 | 2 | 58 | 2.8 | 46.6 | 1 |
| 145 | Charle Young | 1981 | 30 | SFO | TE | 16 | 16 | 37 | 400 | 10.8 | 5 | 29 | 2.3 | 25.0 | 0 |
| 146 | Eric Johnson | 2002 | 23 | SFO | TE | 12 | 10 | 36 | 321 | 8.9 | 0 | 38 | 3.0 | 26.8 | 0 |
| 147 | Dave Parks | 1964* | 23 | SFO | SE | 14 | 14 | 36 | 703 | 19.5 | 8 | 83 | 2.6 | 50.2 | 2 |
| 148 | J.D. Smith | 1960 | 28 | SFO | FB/lh | 12 | 12 | 36 | 181 | 5.0 | 1 | 21 | 3.0 | 15.1 | 1 |
| 149 | Vic Washington | 1971* | 25 | SFO | RB | 14 | 0 | 36 | 317 | 8.8 | 4 | 40 | 2.6 | 22.6 | 10 |
| Rk | Year | Age | Tm | Pos | G | GS | Rec | Yds | TD | Lng | Fmb | ||||
| 150 | Ken Willard | 1969* | 26 | SFO | FB | 14 | 14 | 36 | 326 | 9.1 | 3 | 36 | 2.6 | 23.3 | 6 |
| 151 | Ken Willard | 1968* | 25 | SFO | FB | 14 | 14 | 36 | 232 | 6.4 | 0 | 20 | 2.6 | 16.6 | 4 |
| 152 | Danny Abramowicz | 1973 | 28 | SFO | WR | 12 | 11 | 35 | 442 | 12.6 | 1 | 54 | 2.9 | 36.8 | 0 |
| 153 | Kevan Barlow | 2003 | 24 | SFO | rb | 16 | 4 | 35 | 307 | 8.8 | 1 | 48 | 2.2 | 19.2 | 5 |
| 154 | Kevan Barlow | 2004 | 25 | SFO | RB | 15 | 14 | 35 | 212 | 6.1 | 0 | 15 | 2.3 | 14.1 | 2 |
| 155 | Joe Cribbs | 1986 | 28 | SFO | RB | 14 | 10 | 35 | 346 | 9.9 | 0 | 33 | 2.5 | 24.7 | 5 |
| 156 | Doug Cunningham | 1970 | 25 | SFO | RB | 12 | 0 | 35 | 209 | 6.0 | 0 | 29 | 2.9 | 17.4 | 4 |
| 157 | Terrell Owens | 1996 | 23 | SFO | WR | 16 | 10 | 35 | 520 | 14.9 | 4 | 46 | 2.2 | 32.5 | 1 |
| 158 | Monty Stickles | 1965 | 27 | SFO | TE | 14 | 14 | 35 | 343 | 9.8 | 1 | 22 | 2.5 | 24.5 | 0 |
| 159 | Jed Weaver | 2003 | 27 | SFO | TE | 16 | 16 | 35 |