1981 Week 4
| Sep 27, 1981 | ||
| Buffalo Bills | 24 | Final |
| Cincinnati Bengals | 27 | OT |
| PassYds | Anderson-CIN | 328 |
| RushYds | Johnson-CIN | 85 |
| RecYds | Lewis-BUF | 132 |
| Sep 27, 1981 | ||
| Atlanta Falcons | 17 | Final |
| Cleveland Browns | 28 | |
| PassYds | Sipe-CLE | 215 |
| RushYds | Pruitt-CLE | 99 |
| RecYds | Jenkins-ATL | 136 |
| Sep 27, 1981 | ||
| Oakland Raiders | 0 | Final |
| Detroit Lions | 16 | |
| PassYds | Plunkett-OAK | 102 |
| RushYds | Sims-DET | 133 |
| RecYds | Branch-OAK | 49 |
| Sep 27, 1981 | ||
| Houston Oilers | 17 | Final |
| New York Jets | 33 | |
| PassYds | Todd-NYJ | 312 |
| RushYds | Campbell-HOU | 88 |
| RecYds | Walker-NYJ | 128 |
| Sep 27, 1981 | ||
| Washington Redskins | 13 | Final |
| Philadelphia Eagles | 36 | |
| PassYds | Theismann-WAS | 265 |
| RushYds | Jackson-WAS | 64 |
| RecYds | Metcalf-WAS | 123 |
| Sep 27, 1981 | ||
| New England Patriots | 21 | Final |
| Pittsburgh Steelers | 27 | OT |
| PassYds | Cavanaugh-NWE | 325 |
| RushYds | Pollard-PIT | 75 |
| RecYds | Jackson-NWE | 126 |
| Sep 27, 1981 | ||
| Miami Dolphins | 31 | Final |
| Baltimore Colts | 28 | |
| PassYds | Jones-BAL | 357 |
| RushYds | Dickey-BAL | 77 |
| RecYds | Butler-BAL | 145 |
| Sep 27, 1981 | ||
| Minnesota Vikings | 30 | Final |
| Green Bay Packers | 13 | |
| PassYds | Kramer-MIN | 253 |
| RushYds | Brown-MIN | 109 |
| RecYds | Jefferson-GNB | 121 |
| Sep 27, 1981 | ||
| New York Giants | 10 | Final |
| Dallas Cowboys | 18 | |
| PassYds | Simms-NYG | 285 |
| RushYds | Dorsett-DAL | 70 |
| RecYds | Perkins-NYG | 129 |
| Sep 27, 1981 | ||
| San Diego Chargers | 24 | Final |
| Denver Broncos | 42 | |
| PassYds | Morton-DEN | 308 |
| RushYds | Canada-DEN | 43 |
| RecYds | Watson-DEN | 178 |
| Sep 27, 1981 | ||
| Kansas City Chiefs | 20 | Final |
| Seattle Seahawks | 14 | |
| PassYds | Zorn-SEA | 308 |
| RushYds | Zorn-SEA | 48 |
| RecYds | Hughes-SEA | 103 |
| Sep 27, 1981 | ||
| New Orleans Saints | 14 | Final |
| San Francisco 49ers | 21 | |
| PassYds | Wilson-NOR | 180 |
| RushYds | Rogers-NOR | 115 |
| RecYds | Solomon-SFO | 80 |
| Sep 27, 1981 | ||
| St. Louis Cardinals | 10 | Final |
| Tampa Bay Buccaneers | 20 | |
| PassYds | Williams-TAM | 162 |
| RushYds | Anderson-STL | 97 |
| RecYds | Wilder-TAM | 72 |
| Sep 28, 1981 | ||
| Los Angeles Rams | 24 | Final |
| Chicago Bears | 7 | |
| PassYds | Haden-RAM | 210 |
| RushYds | Tyler-RAM | 68 |
| RecYds | Payton-CHI | 111 |
1981 Week Summaries