All Matchups, Buffalo Bills vs. San Francisco 49ers
Buffalo Bills lead series, 7-6 (all regular season)
Postseason games noted in bold.
13 Games
| Rk | Date | Day | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 1972-09-24 | Sun | W | Buffalo Bills | San Francisco 49ers | 27 | 20 | boxscore | |
| 2 | 1980-12-21 | Sun | W | Buffalo Bills | @ | San Francisco 49ers | 18 | 13 | boxscore |
| 3 | 1983-12-11 | Sun | L | Buffalo Bills | San Francisco 49ers | 10 | 23 | boxscore | |
| 4 | 1989-12-17 | Sun | L | Buffalo Bills | @ | San Francisco 49ers | 10 | 21 | boxscore |
| 5 | 1992-09-13 | Sun | W | Buffalo Bills | @ | San Francisco 49ers | 34 | 31 | boxscore |
| 6 | 1995-12-03 | Sun | L | Buffalo Bills | @ | San Francisco 49ers | 17 | 27 | boxscore |
| 7 | 1998-10-04 | Sun | W | Buffalo Bills | San Francisco 49ers | 26 | 21 | boxscore | |
| 8 | 2001-12-02 | Sun | L | Buffalo Bills | @ | San Francisco 49ers | 0 | 35 | boxscore |
| 9 | 2004-12-26 | Sun | W | Buffalo Bills | @ | San Francisco 49ers | 41 | 7 | boxscore |
| 10 | 2008-11-30 | Sun | L | Buffalo Bills | San Francisco 49ers | 3 | 10 | boxscore | |
| 11 | 2012-10-07 | Sun | L | Buffalo Bills | @ | San Francisco 49ers | 3 | 45 | boxscore |
| 12 | 2016-10-16 | Sun | W | Buffalo Bills | San Francisco 49ers | 45 | 16 | boxscore | |
| 13 | 2020-12-07 | Mon | W | Buffalo Bills | @ | San Francisco 49ers | 34 | 24 | boxscore |
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