All Matchups, San Francisco 49ers vs. Buffalo Bills
Buffalo Bills lead series, 7-6 (all regular season)
Postseason games noted in bold.
13 Games
| Rk | Date | Day | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 1972-09-24 | Sun | L | San Francisco 49ers | @ | Buffalo Bills | 20 | 27 | boxscore |
| 2 | 1980-12-21 | Sun | L | San Francisco 49ers | Buffalo Bills | 13 | 18 | boxscore | |
| 3 | 1983-12-11 | Sun | W | San Francisco 49ers | @ | Buffalo Bills | 23 | 10 | boxscore |
| 4 | 1989-12-17 | Sun | W | San Francisco 49ers | Buffalo Bills | 21 | 10 | boxscore | |
| 5 | 1992-09-13 | Sun | L | San Francisco 49ers | Buffalo Bills | 31 | 34 | boxscore | |
| 6 | 1995-12-03 | Sun | W | San Francisco 49ers | Buffalo Bills | 27 | 17 | boxscore | |
| 7 | 1998-10-04 | Sun | L | San Francisco 49ers | @ | Buffalo Bills | 21 | 26 | boxscore |
| 8 | 2001-12-02 | Sun | W | San Francisco 49ers | Buffalo Bills | 35 | 0 | boxscore | |
| 9 | 2004-12-26 | Sun | L | San Francisco 49ers | Buffalo Bills | 7 | 41 | boxscore | |
| 10 | 2008-11-30 | Sun | W | San Francisco 49ers | @ | Buffalo Bills | 10 | 3 | boxscore |
| 11 | 2012-10-07 | Sun | W | San Francisco 49ers | Buffalo Bills | 45 | 3 | boxscore | |
| 12 | 2016-10-16 | Sun | L | San Francisco 49ers | @ | Buffalo Bills | 16 | 45 | boxscore |
| 13 | 2020-12-07 | Mon | L | San Francisco 49ers | Buffalo Bills | 24 | 34 | boxscore |
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