16 Games
| Rk | Date | Day | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2010-09-12 | Sun | W | Houston Texans | Indianapolis Colts | 34 | 24 | boxscore | |
| 2 | 2010-09-19 | Sun | W | Houston Texans | @ | Washington Redskins | 30 | 27 | boxscore |
| 3 | 2010-09-26 | Sun | L | Houston Texans | Dallas Cowboys | 13 | 27 | boxscore | |
| 4 | 2010-10-03 | Sun | W | Houston Texans | @ | Oakland Raiders | 31 | 24 | boxscore |
| 5 | 2010-10-10 | Sun | L | Houston Texans | New York Giants | 10 | 34 | boxscore | |
| 6 | 2010-10-17 | Sun | W | Houston Texans | Kansas City Chiefs | 35 | 31 | boxscore | |
| 7 | 2010-11-01 | Mon | L | Houston Texans | @ | Indianapolis Colts | 17 | 30 | boxscore |
| 8 | 2010-11-07 | Sun | L | Houston Texans | San Diego Chargers | 23 | 29 | boxscore | |
| 9 | 2010-11-14 | Sun | L | Houston Texans | @ | Jacksonville Jaguars | 24 | 31 | boxscore |
| 10 | 2010-11-21 | Sun | L | Houston Texans | @ | New York Jets | 27 | 30 | boxscore |
| 11 | 2010-11-28 | Sun | W | Houston Texans | Tennessee Titans | 20 | 0 | boxscore | |
| 12 | 2010-12-02 | Thu | L | Houston Texans | @ | Philadelphia Eagles | 24 | 34 | boxscore |
| 13 | 2010-12-13 | Mon | L | Houston Texans | Baltimore Ravens | 28 | 34 | boxscore | |
| 14 | 2010-12-19 | Sun | L | Houston Texans | @ | Tennessee Titans | 17 | 31 | boxscore |
| 15 | 2010-12-26 | Sun | L | Houston Texans | @ | Denver Broncos | 23 | 24 | boxscore |
| 16 | 2011-01-02 | Sun | W | Houston Texans | Jacksonville Jaguars | 34 | 17 | boxscore |
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