| Offensive Starters | | | | | |
| QB | Mitchell Trubisky | 25 | 2 | 15 | 326 for 516, 3,138 yards, 17 td, 10 int, & 48 rushes for 193 yards and 2 td | |
| RB | Tarik Cohen | 24 | 2 | 11 | 64 rushes for 213 yards, 0 td, & 79 catches for 456 yards and 3 td | |
| WR | Taylor Gabriel | 28 | 5 | 7 | 29 catches for 353 yards, 4 td, & 3 rushes for 20 yards and 0 td | |
| WR | Anthony Miller | 25 | 1 | 7 | 52 catches for 656 yards, 2 td, & 1 rush for -1 yards and 0 td | |
| WR | Allen Robinson | 26 | 5 | 15 | 98 catches for 1,147 yards, 7 td, & 1 rush for 2 yards and 0 td | |
| TE | J.P. Holtz | 26 | Rook | 7 | 7 catches for 91 yards, 0 td | |
| LT | Charles Leno Jr. | 28 | 5 | 16 | | |
| LG | James Daniels | 22 | 1 | 16 | | |
| C | Cody Whitehair | 27 | 3 | 16 | | |
| RG | Rashaad Coward | 25 | 2 | 10 | | |
| RT | Bobby Massie | 30 | 7 | 10 | | |
| Defensive Starters | | | | | |
| DE | Roy Robertson-Harris | 26 | 2 | 7 | 2.5 sacks, 0 interceptions, 0 fumbles recovered | |
| DT | Bilal Nichols | 23 | 1 | 12 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
| NT | Eddie Goldman | 25 | 4 | 15 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LOLB | Khalil Mack* | 28 | 5 | 16 | 8.5 sacks, 0 interceptions, 1 fumble recovered | |
| LILB | Danny Trevathan | 29 | 7 | 9 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RILB | Roquan Smith | 22 | 1 | 12 | 2.0 sacks, 1 interception, 0 fumbles recovered | |
| ROLB | Leonard Floyd | 27 | 3 | 16 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LCB | Kyle Fuller* | 27 | 5 | 16 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
| RCB | Prince Amukamara | 30 | 8 | 15 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
| FS | Ha Ha Clinton-Dix | 27 | 5 | 16 | 0.0 sacks, 2 interceptions, 2 fumbles recovered | |
| FS | Eddie Jackson* | 26 | 2 | 16 | 1.0 sacks, 2 interceptions, 1 fumble recovered | |
Roster