Trades
- March 10, 2022: Traded Khalil Mack to Chargers for 2022 2nd round pick (48th overall, Jaquan Brisker) and 2023 6th round pick (200th overall subsequently traded , Scott Matlock)
- April 30, 2022: Traded 2022 5th round pick (148th overall, Khalil Shakir) to Bills for 2022 5th round pick (168th overall, Braxton Jones) and 2022 6th round pick (203rd overall, Trestan Ebner)
- April 30, 2022: Traded 2022 5th round pick (150th overall, Thomas Booker) to Texans for 2022 5th round pick (166th overall subsequently traded , Tycen Anderson) and 2022 6th round pick (207th overall, Doug Kramer)
- April 30, 2022: Traded 2022 5th round pick (166th overall, Tycen Anderson) to Bengals for 2022 5th round pick (174th overall, Dominique Robinson) and 2022 7th round pick (226th overall, Ja'Tyre Carter)
- April 30, 2022: Traded 2023 6th round pick (200th overall, Scott Matlock) to Chargers for 2022 7th round pick (254th overall, Elijah Hicks) and 2022 7th round pick (255th overall, Trenton Gill)
- July 12, 2022: Traded a 2024 7th round pick to Patriots for N'Keal Harry
- October 26, 2022: Traded Robert Quinn to Eagles for 2023 4th round pick (133rd overall, Tyler Scott)
- October 31, 2022: Traded Roquan Smith to Ravens for 2023 2nd round pick (53rd overall, Gervon Dexter), 2023 5th round pick (148th overall, Noah Sewell) and A.J. Klein
- November 1, 2022: Traded 2023 2nd round pick (32nd overall, Joey Porter) to Steelers for Chase Claypool
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