Trades
- March 11, 2022: Traded 2022 6th round pick (193rd overall, Devin Harper) and 2022 5th round pick (155th overall, Matt Waletzko) to Cowboys for Amari Cooper and 2022 6th round pick (202nd overall, Michael Woods)
- March 15, 2022: Traded Mack Wilson to Patriots for Chase Winovich
- March 18, 2022: Traded 2022 1st round pick (13th overall subsequently traded , Jordan Davis), 2023 1st round pick (12th overall subsequently traded , Jahmyr Gibbs), a 2024 1st round pick, 2023 3rd round pick (73rd overall subsequently traded , Jalin Hyatt), a 2024 4th round pick and 2022 4th round pick (107th overall, Dameon Pierce) to Texans for Deshaun Watson and a 2024 6th round pick
- March 19, 2022: Traded Case Keenum to Bills for 2022 7th round pick (246th overall, Dawson Deaton)
- April 29, 2022: Traded 2022 2nd round pick (44th overall, John Metchie) to Texans for 2022 3rd round pick (68th overall, Martin Emerson), 2022 4th round pick (108th overall, Perrion Winfrey) and 2022 4th round pick (124th overall, Cade York)
- April 30, 2022: Traded 2022 4th round pick (118th overall, Akayleb Evans) to Vikings for 2022 5th round pick (156th overall, Jerome Ford) and 2023 4th round pick (126th overall, Isaiah McGuire)
- April 30, 2022: Traded Troy Hill to Rams for 2023 5th round pick (140th overall, Dorian Thompson-Robinson)
- July 6, 2022: Traded Baker Mayfield to Panthers for a 2024 5th round pick
- October 10, 2022: Traded a 2024 6th round pick to Falcons for Deion Jones and a 2024 7th round pick
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