| Offensive Starters | | | | | |
| QB | Kyler Murray | 27 | 5 | 17 | 372 for 541, 3,851 yards, 21 td, 11 int, & 78 rushes for 572 yards and 5 td | |
| RB | James Conner | 29 | 7 | 16 | 236 rushes for 1,094 yards, 8 td, & 47 catches for 414 yards and 1 td | |
| WR | Marvin Harrison Jr. | 22 | Rook | 16 | 62 catches for 885 yards, 8 td | |
| WR | Michael Wilson | 24 | 1 | 13 | 47 catches for 548 yards, 4 td, & 1 rush for 7 yards and 0 td | |
| TE | Trey McBride* | 25 | 2 | 16 | 111 catches for 1,146 yards, 2 td, & 1 rush for 2 yards and 1 td | |
| TE | Tip Reiman | 23 | Rook | 9 | 6 catches for 37 yards, 0 td | |
| LT | Paris Johnson | 23 | 1 | 14 | | |
| LG | Evan Brown | 28 | 5 | 17 | | |
| C | Hjalte Froholdt | 28 | 4 | 17 | 1 fumble recovered | |
| RG | Trystan Colon | 26 | 4 | 7 | | |
| RT | Kelvin Beachum | 35 | 12 | 12 | | |
| Defensive Starters | | | | | |
| LDE | L.J. Collier | 29 | 5 | 15 | 3.5 sacks, 0 interceptions, 1 fumble recovered | |
| DT | Dante Stills | 25 | 1 | 10 | 4.5 sacks, 0 interceptions, 0 fumbles recovered | |
| NT | Roy Lopez | 27 | 3 | 16 | 1.0 sacks, 0 interceptions, 1 fumble recovered | |
| LOLB | Zaven Collins | 25 | 3 | 17 | 5.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LILB | Mack Wilson | 26 | 5 | 16 | 3.0 sacks, 1 interception, 1 fumble recovered | |
| RILB | Kyzir White | 28 | 6 | 17 | 2.5 sacks, 1 interception, 1 fumble recovered | |
| LCB | Garrett Williams | 23 | 1 | 11 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| RCB | Starling Thomas | 24 | 1 | 15 | | |
| SS | Jalen Thompson | 26 | 5 | 15 | 0.0 sacks, 0 interceptions, 2 fumbles recovered | |
| FS | Budda Baker* | 28 | 7 | 17 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
| DB | Sean Murphy-Bunting | 27 | 5 | 15 | | |
Roster