| Offensive Starters | | | | | |
|---|
| QB | Jared Goff | 27 | 5 | 14 | 332 for 494, 3,245 yards, 19 td, 8 int, & 17 rushes for 87 yards and 0 td | |
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| RB | Jamaal Williams | 26 | 4 | 11 | 153 rushes for 601 yards, 3 td, & 26 catches for 157 yards and 0 td | |
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| WR | Kalif Raymond | 27 | 5 | 14 | 48 catches for 576 yards, 4 td, & 4 rushes for 28 yards and 0 td | |
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| WR | Amon-Ra St. Brown | 22 | Rook | 9 | 90 catches for 912 yards, 5 td, & 7 rushes for 61 yards and 1 td | |
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| TE | Darren Fells | 35 | 7 | 5 | 4 catches for 43 yards, 0 td | |
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| TE | T.J. Hockenson | 24 | 2 | 12 | 61 catches for 583 yards, 4 td | |
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| LT | Taylor Decker | 28 | 5 | 9 | | |
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| LG | Jonah Jackson* | 24 | 1 | 16 | | |
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| C | Evan Brown | 25 | 2 | 12 | 1 fumble recovered | |
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| RG | Halapoulivaati Vaitai | 28 | 5 | 15 | | |
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| Defensive Starters | | | | | |
|---|
| LDE | Michael Brockers | 31 | 9 | 16 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| NT | Alim McNeill | 21 | Rook | 6 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDE | Nick Williams | 31 | 7 | 17 | 0.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LOLB | Trey Flowers | 28 | 6 | 7 | 1.5 sacks, 0 interceptions, 1 fumble recovered | |
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| LILB | Alex Anzalone | 27 | 4 | 14 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
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| RILB | Jalen Reeves-Maybin | 26 | 4 | 11 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
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| ROLB | Charles Harris | 26 | 4 | 14 | 7.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LCB | Jerry Jacobs | 24 | Rook | 9 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
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| RCB | Amani Oruwariye | 25 | 2 | 14 | 0.0 sacks, 6 interceptions, 1 fumble recovered | |
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| SS | Tracy Walker | 26 | 3 | 15 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
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| FS | Will Harris | 26 | 2 | 17 | 0.5 sacks, 0 interceptions, 0 fumbles recovered | |
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Roster