| Offensive Starters | | | | | |
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| QB | C.J. Stroud | 23 | 1 | 17 | 336 for 532, 3,727 yards, 20 td, 12 int, & 52 rushes for 233 yards and 0 td | |
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| RB | Joe Mixon* | 28 | 7 | 14 | 245 rushes for 1,016 yards, 11 td, & 36 catches for 309 yards and 1 td | |
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| WR | Nico Collins* | 25 | 3 | 12 | 68 catches for 1,006 yards, 7 td | |
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| WR | Tank Dell | 25 | 1 | 10 | 51 catches for 667 yards, 3 td, & 9 rushes for 43 yards and 0 td | |
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| TE | Dalton Schultz | 28 | 6 | 13 | 53 catches for 532 yards, 2 td | |
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| TE | Cade Stover | 24 | Rook | 9 | 15 catches for 133 yards, 1 td | |
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| LT | Laremy Tunsil* | 30 | 8 | 17 | | |
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| LG | Kenyon Green | 23 | 2 | 9 | | |
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| C | Jarrett Patterson | 25 | 1 | 9 | | |
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| RG | Shaq Mason | 31 | 9 | 15 | | |
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| RT | Tytus Howard | 28 | 5 | 16 | 1 fumble recovered | |
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| Defensive Starters | | | | | |
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| LDE | Will Anderson | 23 | 1 | 14 | 11.0 sacks, 0 interceptions, 1 fumble recovered | |
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| LDT | Folorunso Fatukasi | 29 | 6 | 11 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDT | Tim Settle | 27 | 6 | 11 | 5.0 sacks, 0 interceptions, 1 fumble recovered | |
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| RDE | Danielle Hunter* | 30 | 9 | 17 | 12.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| LLB | Henry To'oTo'o | 23 | 1 | 15 | 1.5 sacks, 1 interception, 0 fumbles recovered | |
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| MLB | Azeez Al-Shaair | 27 | 5 | 11 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| LCB | Derek Stingley Jr.*+ | 23 | 2 | 17 | 0.0 sacks, 5 interceptions, 0 fumbles recovered | |
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| RCB | Kamari Lassiter | 21 | Rook | 14 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
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| SS | Eric Murray | 30 | 8 | 14 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
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| FS | Calen Bullock | 21 | Rook | 13 | 0.0 sacks, 5 interceptions, 1 fumble recovered | |
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| DB | Jalen Pitre | 25 | 2 | 12 | | |
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Roster