| Offensive Starters | | | | | |
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| QB | Gardner Minshew II | 23 | Rook | 12 | 285 for 470, 3,271 yards, 21 td, 6 int, & 67 rushes for 344 yards and 0 td | |
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| RB | Leonard Fournette | 24 | 2 | 15 | 265 rushes for 1,152 yards, 3 td, & 76 catches for 522 yards and 0 td | |
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| WR | DJ Chark* | 23 | 1 | 14 | 73 catches for 1,008 yards, 8 td, & 2 rushes for 20 yards and 0 td | |
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| WR | Chris Conley | 27 | 4 | 14 | 47 catches for 775 yards, 5 td | |
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| WR | Dede Westbrook | 26 | 2 | 11 | 66 catches for 660 yards, 3 td, & 5 rushes for 27 yards and 0 td | |
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| TE | James O'Shaughnessy | 27 | 4 | 5 | 14 catches for 153 yards, 2 td | |
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| LT | Cam Robinson | 24 | 2 | 14 | 1 fumble recovered | |
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| LG | Andrew Norwell | 28 | 5 | 16 | | |
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| C | Brandon Linder | 27 | 5 | 16 | 1 fumble recovered | |
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| RG | A.J. Cann | 28 | 4 | 16 | 1 fumble recovered | |
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| RT | Jawaan Taylor | 22 | Rook | 16 | | |
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| Defensive Starters | | | | | |
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| LDE | Yannick Ngakoue | 24 | 3 | 15 | 8.0 sacks, 1 interception, 1 fumble recovered | |
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| LDT | Abry Jones | 28 | 6 | 15 | 2.0 sacks, 0 interceptions, 1 fumble recovered | |
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| RDT | Taven Bryan | 23 | 1 | 8 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| RDE | Calais Campbell* | 33 | 11 | 16 | 6.5 sacks, 0 interceptions, 1 fumble recovered | |
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| LLB | Quincy Williams | 23 | Rook | 8 | | |
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| MLB | Myles Jack | 24 | 3 | 11 | 0.5 sacks, 1 interception, 0 fumbles recovered | |
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| RLB | Leon Jacobs | 24 | 1 | 7 | 2.0 sacks, 0 interceptions, 1 fumble recovered | |
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| LCB | Tre Herndon | 23 | 1 | 14 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
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| RCB | A.J. Bouye | 28 | 6 | 14 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
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| SS | Ronnie Harrison | 22 | 1 | 14 | 2.0 sacks, 2 interceptions, 1 fumble recovered | |
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| FS | Jarrod Wilson | 25 | 3 | 16 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
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Roster