| Offensive Starters | | | | | |
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| QB | Trevor Lawrence* | 23 | 1 | 17 | 387 for 584, 4,113 yards, 25 td, 8 int, & 62 rushes for 291 yards and 5 td | |
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| RB | Travis Etienne | 23 | Rook | 12 | 220 rushes for 1,125 yards, 5 td, & 35 catches for 316 yards and 0 td | |
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| WR | Zay Jones | 27 | 5 | 15 | 82 catches for 823 yards, 5 td, & 4 rushes for 18 yards and 0 td | |
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| WR | Christian Kirk | 26 | 4 | 17 | 84 catches for 1,108 yards, 8 td, & 5 rushes for 11 yards and 0 td | |
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| TE | Evan Engram | 28 | 5 | 14 | 73 catches for 766 yards, 4 td, & 2 rushes for 13 yards and 0 td | |
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| TE | Chris Manhertz | 30 | 6 | 11 | 6 catches for 42 yards, 0 td | |
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| LT | Cam Robinson | 27 | 5 | 14 | | |
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| LG | Tyler Shatley | 31 | 8 | 12 | 1 fumble recovered | |
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| C | Luke Fortner | 24 | Rook | 17 | 1 fumble recovered | |
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| RG | Brandon Scherff | 31 | 7 | 17 | | |
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| RT | Jawaan Taylor | 25 | 3 | 17 | | |
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| Defensive Starters | | | | | |
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| LDE | Roy Robertson-Harris | 29 | 5 | 17 | 3.0 sacks, 0 interceptions, 0 fumbles recovered | |
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| NT | DaVon Hamilton | 25 | 2 | 14 | 2.5 sacks, 0 interceptions, 1 fumble recovered | |
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| RDE | Folorunso Fatukasi | 27 | 4 | 13 | 1.5 sacks, 0 interceptions, 0 fumbles recovered | |
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| LOLB | Josh Allen | 25 | 3 | 17 | 7.0 sacks, 0 interceptions, 2 fumbles recovered | |
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| LILB | Foyesade Oluokun | 27 | 4 | 17 | 2.0 sacks, 0 interceptions, 2 fumbles recovered | |
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| RILB | Devin Lloyd | 24 | Rook | 15 | 0.0 sacks, 3 interceptions, 2 fumbles recovered | |
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| ROLB | Travon Walker | 22 | Rook | 14 | 3.5 sacks, 1 interception, 0 fumbles recovered | |
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| LCB | Darious Williams | 29 | 4 | 12 | | |
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| RCB | Tyson Campbell | 22 | 1 | 17 | 0.0 sacks, 3 interceptions, 2 fumbles recovered | |
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| SS | Rayshawn Jenkins | 28 | 5 | 17 | 1.0 sacks, 3 interceptions, 0 fumbles recovered | |
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| FS | Andre Cisco | 22 | 1 | 15 | 1.0 sacks, 3 interceptions, 0 fumbles recovered | |
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Roster