| Offensive Starters | | | | | |
| QB | Trevor Lawrence | 26 | 4 | 17 | 341 for 560, 4,007 yards, 29 td, 12 int, & 82 rushes for 359 yards and 9 td | |
| RB | Travis Etienne | 26 | 3 | 16 | 260 rushes for 1,107 yards, 7 td, & 36 catches for 292 yards and 6 td | |
| WR | Brian Thomas | 23 | 1 | 14 | 48 catches for 707 yards, 2 td, & 3 rushes for 21 yards and 1 td | |
| WR | Parker Washington | 23 | 2 | 7 | 58 catches for 847 yards, 5 td, & 7 rushes for yards and 0 td | |
| TE | Brenton Strange | 25 | 2 | 12 | 46 catches for 540 yards, 3 td | |
| LT | Walker Little | 26 | 4 | 14 | | |
| LG | Ezra Cleveland | 27 | 5 | 16 | | |
| C | Robert Hainsey | 27 | 4 | 15 | | |
| RG | Patrick Mekari | 28 | 6 | 14 | | |
| RT | Anton Harrison | 23 | 2 | 15 | 1 fumble recovered | |
| Defensive Starters | | | | | |
| DE | Josh Hines-Allen | 28 | 6 | 17 | 8.0 sacks, 0 interceptions, 0 fumbles recovered | |
| DE | Travon Walker | 25 | 3 | 12 | 3.5 sacks, 0 interceptions, 0 fumbles recovered | |
| DT | Arik Armstead | 32 | 10 | 11 | 5.5 sacks, 0 interceptions, 0 fumbles recovered | |
| DT | DaVon Hamilton | 28 | 5 | 17 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LB | Devin Lloyd* | 27 | 3 | 15 | 1.5 sacks, 5 interceptions, 1 fumble recovered | |
| LB | Foyesade Oluokun | 30 | 7 | 17 | 1.0 sacks, 1 interception, 1 fumble recovered | |
| CB | Montaric Brown | 26 | 3 | 12 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| CB | Greg Newsome II | 25 | 4 | 11 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| S | Antonio Johnson | 24 | 2 | 9 | 2.0 sacks, 5 interceptions, 0 fumbles recovered | |
| S | Eric Murray | 31 | 9 | 12 | 1.0 sacks, 1 interception, 0 fumbles recovered | |
| S | Andrew Wingard | 29 | 6 | 16 | 0.0 sacks, 1 interception, 1 fumble recovered | |
Roster