| Offensive Starters | | | | | |
| QB | Patrick Mahomes* | 26 | 4 | 17 | 436 for 658, 4,839 yards, 37 td, 13 int, & 66 rushes for 381 yards and 2 td | |
| RB | Clyde Edwards-Helaire | 22 | 1 | 10 | 119 rushes for 517 yards, 4 td, & 19 catches for 129 yards and 2 td | |
| WR | Mecole Hardman | 23 | 2 | 8 | 59 catches for 693 yards, 2 td, & 8 rushes for 46 yards and 0 td | |
| WR | Tyreek Hill* | 27 | 5 | 16 | 111 catches for 1,239 yards, 9 td, & 9 rushes for 96 yards and 0 td | |
| WR | Demarcus Robinson | 27 | 5 | 10 | 25 catches for 264 yards, 3 td | |
| TE | Travis Kelce* | 32 | 8 | 16 | 92 catches for 1,125 yards, 9 td, & 2 rushes for 3 yards and 1 td | |
| LT | Orlando Brown Jr.* | 25 | 3 | 16 | | |
| LG | Joe Thuney | 29 | 5 | 17 | 1 fumble recovered | |
| C | Creed Humphrey | 22 | Rook | 17 | | |
| RG | Trey Smith | 22 | Rook | 17 | 1 fumble recovered | |
| RT | Lucas Niang | 23 | 1 | 9 | | |
| Defensive Starters | | | | | |
| LDE | Melvin Ingram | 32 | 9 | 6 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LDT | Jarran Reed | 29 | 5 | 17 | 2.5 sacks, 0 interceptions, 1 fumble recovered | |
| RDT | Chris Jones* | 27 | 5 | 14 | 9.0 sacks, 0 interceptions, 1 fumble recovered | |
| RDE | Frank Clark* | 28 | 6 | 14 | 4.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LLB | Willie Gay Jr. | 23 | 1 | 11 | 0.5 sacks, 2 interceptions, 0 fumbles recovered | |
| MLB | Anthony Hitchens | 29 | 7 | 15 | 0.0 sacks, 1 interception, 0 fumbles recovered | |
| RLB | Nick Bolton | 21 | Rook | 12 | 0.0 sacks, 0 interceptions, 1 fumble recovered | |
| LCB | Charvarius Ward | 25 | 3 | 12 | 0.0 sacks, 2 interceptions, 0 fumbles recovered | |
| RCB | L'Jarius Sneed | 24 | 1 | 15 | 1.0 sacks, 2 interceptions, 1 fumble recovered | |
| SS | Tyrann Mathieu* | 29 | 8 | 16 | 1.0 sacks, 3 interceptions, 3 fumbles recovered | |
| FS | Juan Thornhill | 26 | 2 | 12 | 0.0 sacks, 1 interception, 1 fumble recovered | |
Roster