| Offensive Starters | | | | | |
| QB | Geno Smith | 34 | 11 | 17 | 407 for 578, 4,320 yards, 21 td, 15 int, & 53 rushes for 272 yards and 2 td | |
| RB | Kenneth Walker III | 24 | 2 | 11 | 153 rushes for 573 yards, 7 td, & 46 catches for 299 yards and 1 td | |
| WR | Tyler Lockett | 32 | 9 | 14 | 49 catches for 600 yards, 2 td | |
| WR | D.K. Metcalf | 27 | 5 | 12 | 66 catches for 992 yards, 5 td | |
| WR | Jaxon Smith-Njigba* | 22 | 1 | 16 | 100 catches for 1,130 yards, 6 td, & 5 rushes for 26 yards and 0 td | |
| TE | Noah Fant | 27 | 5 | 9 | 48 catches for 500 yards, 1 td | |
| LT | Charles Cross | 24 | 2 | 17 | | |
| LG | Laken Tomlinson | 32 | 9 | 17 | 1 fumble recovered | |
| C | Connor Williams | 27 | 6 | 9 | | |
| RG | Anthony Bradford | 23 | 1 | 11 | 1 fumble recovered | |
| RT | Abraham Lucas | 26 | 2 | 7 | | |
| Defensive Starters | | | | | |
| LDE | Leonard Williams* | 30 | 9 | 16 | 11.0 sacks, 1 interception, 0 fumbles recovered | |
| NT | Byron Murphy | 22 | Rook | 9 | 0.5 sacks, 0 interceptions, 0 fumbles recovered | |
| RDE | Jarran Reed | 32 | 8 | 8 | 4.5 sacks, 0 interceptions, 0 fumbles recovered | |
| LOLB | Boye Mafe | 26 | 2 | 11 | 6.0 sacks, 0 interceptions, 0 fumbles recovered | |
| LILB | Tyrel Dodson | 26 | 4 | 9 | 2.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RILB | Derick Hall | 23 | 1 | 14 | 8.0 sacks, 0 interceptions, 1 fumble recovered | |
| ROLB | Tyrice Knight | 24 | Rook | 9 | 1.5 sacks, 0 interceptions, 1 fumble recovered | |
| LCB | Devon Witherspoon* | 24 | 1 | 17 | 1.0 sacks, 0 interceptions, 0 fumbles recovered | |
| RCB | Riq Woolen | 25 | 2 | 14 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
| SS | Coby Bryant | 25 | 2 | 11 | 0.0 sacks, 3 interceptions, 0 fumbles recovered | |
| FS | Julian Love | 26 | 5 | 17 | 0.0 sacks, 3 interceptions, 1 fumble recovered | |
Roster