| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 7, 2003 | W | Buffalo Bills | New England Patriots | 31 | 0 | box | |
| 2 | Sun | September 14, 2003 | W | Buffalo Bills | @ | Jacksonville Jaguars | 38 | 17 | box |
| 3 | Sun | September 21, 2003 | L | Buffalo Bills | @ | Miami Dolphins | 7 | 17 | box |
| 4 | Sun | September 28, 2003 | L | Buffalo Bills | Philadelphia Eagles | 13 | 23 | box | |
| 5 | Sun | October 5, 2003 | W | Buffalo Bills | Cincinnati Bengals | 22 | 16 | box | |
| 6 | Sun | October 12, 2003 | L | Buffalo Bills | @ | New York Jets | 3 | 30 | box |
| 7 | Sun | October 19, 2003 | W | Buffalo Bills | Washington Redskins | 24 | 7 | box | |
| 8 | Sun | October 26, 2003 | L | Buffalo Bills | @ | Kansas City Chiefs | 5 | 38 | box |
| 9 | Sun | November 9, 2003 | L | Buffalo Bills | @ | Dallas Cowboys | 6 | 10 | box |
| 10 | Sun | November 16, 2003 | L | Buffalo Bills | Houston Texans | 10 | 12 | box | |
| 11 | Sun | November 23, 2003 | L | Buffalo Bills | Indianapolis Colts | 14 | 17 | box | |
| 12 | Sun | November 30, 2003 | W | Buffalo Bills | @ | New York Giants | 24 | 7 | box |
| 13 | Sun | December 7, 2003 | W | Buffalo Bills | New York Jets | 17 | 6 | box | |
| 14 | Sun | December 14, 2003 | L | Buffalo Bills | @ | Tennessee Titans | 26 | 28 | box |
| 15 | Sun | December 21, 2003 | L | Buffalo Bills | Miami Dolphins | 3 | 20 | box | |
| 16 | Sat | December 27, 2003 | L | Buffalo Bills | @ | New England Patriots | 0 | 31 | box |