| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 3, 2000 | W | New York Giants | Arizona Cardinals | 21 | 16 | box | |
| 2 | Sun | September 10, 2000 | W | New York Giants | @ | Philadelphia Eagles | 33 | 18 | box |
| 3 | Sun | September 17, 2000 | W | New York Giants | @ | Chicago Bears | 14 | 7 | box |
| 4 | Sun | September 24, 2000 | L | New York Giants | Washington Redskins | 6 | 16 | box | |
| 5 | Sun | October 1, 2000 | L | New York Giants | @ | Tennessee Titans | 14 | 28 | box |
| 6 | Sun | October 8, 2000 | W | New York Giants | @ | Atlanta Falcons | 13 | 6 | box |
| 7 | Sun | October 15, 2000 | W | New York Giants | Dallas Cowboys | 19 | 14 | box | |
| 8 | Sun | October 29, 2000 | W | New York Giants | Philadelphia Eagles | 24 | 7 | box | |
| 9 | Sun | November 5, 2000 | W | New York Giants | @ | Cleveland Browns | 24 | 3 | box |
| 10 | Sun | November 12, 2000 | L | New York Giants | St. Louis Rams | 24 | 38 | box | |
| 11 | Sun | November 19, 2000 | L | New York Giants | Detroit Lions | 21 | 31 | box | |
| 12 | Sun | November 26, 2000 | W | New York Giants | @ | Arizona Cardinals | 31 | 7 | box |
| 13 | Sun | December 3, 2000 | W | New York Giants | @ | Washington Redskins | 9 | 7 | box |
| 14 | Sun | December 10, 2000 | W | New York Giants | Pittsburgh Steelers | 30 | 10 | box | |
| 15 | Sun | December 17, 2000 | W | New York Giants | @ | Dallas Cowboys | 17 | 13 | box |
| 16 | Sat | December 23, 2000 | W | New York Giants | Jacksonville Jaguars | 28 | 25 | box | |
| 17 | Sun | January 7, 2001 | W | New York Giants | Philadelphia Eagles | 20 | 10 | box | |
| 18 | Sun | January 14, 2001 | W | New York Giants | Minnesota Vikings | 41 | 0 | box | |
| 19 | Sun | January 28, 2001 | L | New York Giants | N | Baltimore Ravens | 7 | 34 | box |