| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 3, 2000 | W | Minnesota Vikings | Chicago Bears | 30 | 27 | box | |
| 2 | Sun | September 10, 2000 | W | Minnesota Vikings | Miami Dolphins | 13 | 7 | box | |
| 3 | Sun | September 17, 2000 | W | Minnesota Vikings | @ | New England Patriots | 21 | 13 | box |
| 4 | Sun | October 1, 2000 | W | Minnesota Vikings | @ | Detroit Lions | 31 | 24 | box |
| 5 | Mon | October 9, 2000 | W | Minnesota Vikings | Tampa Bay Buccaneers | 30 | 23 | box | |
| 6 | Sun | October 15, 2000 | W | Minnesota Vikings | @ | Chicago Bears | 28 | 16 | box |
| 7 | Sun | October 22, 2000 | W | Minnesota Vikings | Buffalo Bills | 31 | 27 | box | |
| 8 | Sun | October 29, 2000 | L | Minnesota Vikings | @ | Tampa Bay Buccaneers | 13 | 41 | box |
| 9 | Mon | November 6, 2000 | L | Minnesota Vikings | @ | Green Bay Packers | 20 | 26 | box |
| 10 | Sun | November 12, 2000 | W | Minnesota Vikings | Arizona Cardinals | 31 | 14 | box | |
| 11 | Sun | November 19, 2000 | W | Minnesota Vikings | Carolina Panthers | 31 | 17 | box | |
| 12 | Thu | November 23, 2000 | W | Minnesota Vikings | @ | Dallas Cowboys | 27 | 15 | box |
| 13 | Thu | November 30, 2000 | W | Minnesota Vikings | Detroit Lions | 24 | 17 | box | |
| 14 | Sun | December 10, 2000 | L | Minnesota Vikings | @ | St. Louis Rams | 29 | 40 | box |
| 15 | Sun | December 17, 2000 | L | Minnesota Vikings | Green Bay Packers | 28 | 33 | box | |
| 16 | Sun | December 24, 2000 | L | Minnesota Vikings | @ | Indianapolis Colts | 10 | 31 | box |
| 17 | Sat | January 6, 2001 | W | Minnesota Vikings | New Orleans Saints | 34 | 16 | box | |
| 18 | Sun | January 14, 2001 | L | Minnesota Vikings | @ | New York Giants | 0 | 41 | box |