| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 7, 1980 | W | New England Patriots | Cleveland Browns | 34 | 17 | box | |
| 2 | Sun | September 14, 1980 | L | New England Patriots | Atlanta Falcons | 21 | 37 | box | |
| 3 | Sun | September 21, 1980 | W | New England Patriots | @ | Seattle Seahawks | 37 | 31 | box |
| 4 | Mon | September 29, 1980 | W | New England Patriots | Denver Broncos | 23 | 14 | box | |
| 5 | Sun | October 5, 1980 | W | New England Patriots | @ | New York Jets | 21 | 11 | box |
| 6 | Sun | October 12, 1980 | W | New England Patriots | Miami Dolphins | 34 | 0 | box | |
| 7 | Sun | October 19, 1980 | W | New England Patriots | @ | Baltimore Colts | 37 | 21 | box |
| 8 | Sun | October 26, 1980 | L | New England Patriots | @ | Buffalo Bills | 13 | 31 | box |
| 9 | Sun | November 2, 1980 | W | New England Patriots | New York Jets | 34 | 21 | box | |
| 10 | Mon | November 10, 1980 | L | New England Patriots | @ | Houston Oilers | 34 | 38 | box |
| 11 | Sun | November 16, 1980 | L | New England Patriots | Los Angeles Rams | 14 | 17 | box | |
| 12 | Sun | November 30, 1980 | L | New England Patriots | @ | San Francisco 49ers | 17 | 21 | box |