| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 3, 2000 | W | Buffalo Bills | Tennessee Titans | 16 | 13 | box | |
| 2 | Sun | September 10, 2000 | W | Buffalo Bills | Green Bay Packers | 27 | 18 | box | |
| 3 | Sun | September 17, 2000 | L | Buffalo Bills | @ | New York Jets | 14 | 27 | box |
| 4 | Sun | October 1, 2000 | L | Buffalo Bills | Indianapolis Colts | 16 | 18 | box | |
| 5 | Sun | October 8, 2000 | L | Buffalo Bills | @ | Miami Dolphins | 13 | 22 | box |
| 6 | Sun | October 15, 2000 | W | Buffalo Bills | San Diego Chargers | 27 | 24 | box | |
| 7 | Sun | November 19, 2000 | W | Buffalo Bills | @ | Kansas City Chiefs | 21 | 17 | box |
| 8 | Sun | November 26, 2000 | L | Buffalo Bills | @ | Tampa Bay Buccaneers | 17 | 31 | box |
| 9 | Sun | December 3, 2000 | L | Buffalo Bills | Miami Dolphins | 6 | 33 | box | |
| 10 | Mon | December 11, 2000 | L | Buffalo Bills | @ | Indianapolis Colts | 20 | 44 | box |
| 11 | Sun | December 17, 2000 | L | Buffalo Bills | New England Patriots | 10 | 13 | box |