| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 10, 2006 | L | Buffalo Bills | @ | New England Patriots | 17 | 19 | box |
| 2 | Sun | September 17, 2006 | W | Buffalo Bills | @ | Miami Dolphins | 16 | 6 | box |
| 3 | Sun | September 24, 2006 | L | Buffalo Bills | New York Jets | 20 | 28 | box | |
| 4 | Sun | October 1, 2006 | W | Buffalo Bills | Minnesota Vikings | 17 | 12 | box | |
| 5 | Sun | October 8, 2006 | L | Buffalo Bills | @ | Chicago Bears | 7 | 40 | box |
| 6 | Sun | October 15, 2006 | L | Buffalo Bills | @ | Detroit Lions | 17 | 20 | box |
| 7 | Sun | October 22, 2006 | L | Buffalo Bills | New England Patriots | 6 | 28 | box | |
| 8 | Sun | November 5, 2006 | W | Buffalo Bills | Green Bay Packers | 24 | 10 | box | |
| 9 | Sun | November 12, 2006 | L | Buffalo Bills | @ | Indianapolis Colts | 16 | 17 | box |
| 10 | Sun | November 19, 2006 | W | Buffalo Bills | @ | Houston Texans | 24 | 21 | box |
| 11 | Sun | November 26, 2006 | W | Buffalo Bills | Jacksonville Jaguars | 27 | 24 | box | |
| 12 | Sun | December 3, 2006 | L | Buffalo Bills | San Diego Chargers | 21 | 24 | box | |
| 13 | Sun | December 10, 2006 | W | Buffalo Bills | @ | New York Jets | 31 | 13 | box |
| 14 | Sun | December 17, 2006 | W | Buffalo Bills | Miami Dolphins | 21 | 0 | box | |
| 15 | Sun | December 24, 2006 | L | Buffalo Bills | Tennessee Titans | 29 | 30 | box | |
| 16 | Sun | December 31, 2006 | L | Buffalo Bills | @ | Baltimore Ravens | 7 | 19 | box |