| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 12, 1999 | W | Indianapolis Colts | Buffalo Bills | 31 | 14 | box | |
| 2 | Sun | September 19, 1999 | L | Indianapolis Colts | @ | New England Patriots | 28 | 31 | box |
| 3 | Sun | September 26, 1999 | W | Indianapolis Colts | @ | San Diego Chargers | 27 | 19 | box |
| 4 | Sun | October 10, 1999 | L | Indianapolis Colts | Miami Dolphins | 31 | 34 | box | |
| 5 | Sun | October 17, 1999 | W | Indianapolis Colts | @ | New York Jets | 16 | 13 | box |
| 6 | Sun | October 24, 1999 | W | Indianapolis Colts | Cincinnati Bengals | 31 | 10 | box | |
| 7 | Sun | October 31, 1999 | W | Indianapolis Colts | Dallas Cowboys | 34 | 24 | box | |
| 8 | Sun | November 7, 1999 | W | Indianapolis Colts | Kansas City Chiefs | 25 | 17 | box | |
| 9 | Sun | November 14, 1999 | W | Indianapolis Colts | @ | New York Giants | 27 | 19 | box |
| 10 | Sun | November 21, 1999 | W | Indianapolis Colts | @ | Philadelphia Eagles | 44 | 17 | box |
| 11 | Sun | November 28, 1999 | W | Indianapolis Colts | New York Jets | 13 | 6 | box | |
| 12 | Sun | December 5, 1999 | W | Indianapolis Colts | @ | Miami Dolphins | 37 | 34 | box |
| 13 | Sun | December 12, 1999 | W | Indianapolis Colts | New England Patriots | 20 | 15 | box | |
| 14 | Sun | December 19, 1999 | W | Indianapolis Colts | Washington Redskins | 24 | 21 | box | |
| 15 | Sun | December 26, 1999 | W | Indianapolis Colts | @ | Cleveland Browns | 29 | 28 | box |
| 16 | Sun | January 2, 2000 | L | Indianapolis Colts | @ | Buffalo Bills | 6 | 31 | box |
| 17 | Sun | January 16, 2000 | L | Indianapolis Colts | Tennessee Titans | 16 | 19 | box |