| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 3, 2000 | L | Tennessee Titans | @ | Buffalo Bills | 13 | 16 | box |
| 2 | Sun | September 10, 2000 | W | Tennessee Titans | Kansas City Chiefs | 17 | 14 | box | |
| 3 | Sun | October 1, 2000 | W | Tennessee Titans | New York Giants | 28 | 14 | box | |
| 4 | Sun | October 8, 2000 | W | Tennessee Titans | @ | Cincinnati Bengals | 23 | 14 | box |
| 5 | Mon | October 16, 2000 | W | Tennessee Titans | Jacksonville Jaguars | 27 | 13 | box | |
| 6 | Sun | October 22, 2000 | W | Tennessee Titans | @ | Baltimore Ravens | 14 | 6 | box |
| 7 | Mon | October 30, 2000 | W | Tennessee Titans | @ | Washington Redskins | 27 | 21 | box |
| 8 | Sun | November 5, 2000 | W | Tennessee Titans | Pittsburgh Steelers | 9 | 7 | box | |
| 9 | Sun | November 12, 2000 | L | Tennessee Titans | Baltimore Ravens | 23 | 24 | box | |
| 10 | Sun | November 19, 2000 | W | Tennessee Titans | Cleveland Browns | 24 | 10 | box | |
| 11 | Sun | November 26, 2000 | L | Tennessee Titans | @ | Jacksonville Jaguars | 13 | 16 | box |
| 12 | Sun | December 3, 2000 | W | Tennessee Titans | @ | Philadelphia Eagles | 15 | 13 | box |
| 13 | Sun | December 10, 2000 | W | Tennessee Titans | Cincinnati Bengals | 35 | 3 | box | |
| 14 | Sun | December 17, 2000 | W | Tennessee Titans | @ | Cleveland Browns | 24 | 0 | box |
| 15 | Mon | December 25, 2000 | W | Tennessee Titans | Dallas Cowboys | 31 | 0 | box | |
| 16 | Sun | January 7, 2001 | L | Tennessee Titans | Baltimore Ravens | 10 | 24 | box |