| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 7, 2008 | W | Chicago Bears | @ | Indianapolis Colts | 29 | 13 | box |
| 2 | Sun | September 14, 2008 | L | Chicago Bears | @ | Carolina Panthers | 17 | 20 | box |
| 3 | Sun | September 21, 2008 | L | Chicago Bears | Tampa Bay Buccaneers | 24 | 27 | box | |
| 4 | Sun | September 28, 2008 | W | Chicago Bears | Philadelphia Eagles | 24 | 20 | box | |
| 5 | Sun | October 5, 2008 | W | Chicago Bears | @ | Detroit Lions | 34 | 7 | box |
| 6 | Sun | October 12, 2008 | L | Chicago Bears | @ | Atlanta Falcons | 20 | 22 | box |
| 7 | Sun | October 19, 2008 | W | Chicago Bears | Minnesota Vikings | 48 | 41 | box | |
| 8 | Sun | November 2, 2008 | W | Chicago Bears | Detroit Lions | 27 | 23 | box | |
| 9 | Sun | November 16, 2008 | L | Chicago Bears | @ | Green Bay Packers | 3 | 37 | box |
| 10 | Sun | November 23, 2008 | W | Chicago Bears | @ | St. Louis Rams | 27 | 3 | box |
| 11 | Sun | November 30, 2008 | L | Chicago Bears | @ | Minnesota Vikings | 14 | 34 | box |
| 12 | Sun | December 7, 2008 | W | Chicago Bears | Jacksonville Jaguars | 23 | 10 | box | |
| 13 | Thu | December 11, 2008 | W | Chicago Bears | New Orleans Saints | 27 | 24 | box | |
| 14 | Mon | December 22, 2008 | W | Chicago Bears | Green Bay Packers | 20 | 17 | box | |
| 15 | Sun | December 28, 2008 | L | Chicago Bears | @ | Houston Texans | 24 | 31 | box |