| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 11, 2005 | L | Denver Broncos | @ | Miami Dolphins | 10 | 34 | box |
| 2 | Sun | September 18, 2005 | W | Denver Broncos | San Diego Chargers | 20 | 17 | box | |
| 3 | Mon | September 26, 2005 | W | Denver Broncos | Kansas City Chiefs | 30 | 10 | box | |
| 4 | Sun | October 2, 2005 | W | Denver Broncos | @ | Jacksonville Jaguars | 20 | 7 | box |
| 5 | Sun | October 9, 2005 | W | Denver Broncos | Washington Redskins | 21 | 19 | box | |
| 6 | Sun | October 16, 2005 | W | Denver Broncos | New England Patriots | 28 | 20 | box | |
| 7 | Sun | October 23, 2005 | L | Denver Broncos | @ | New York Giants | 23 | 24 | box |
| 8 | Sun | October 30, 2005 | W | Denver Broncos | Philadelphia Eagles | 49 | 21 | box | |
| 9 | Sun | November 13, 2005 | W | Denver Broncos | @ | Oakland Raiders | 31 | 17 | box |
| 10 | Sun | November 20, 2005 | W | Denver Broncos | New York Jets | 27 | 0 | box | |
| 11 | Thu | November 24, 2005 | W | Denver Broncos | @ | Dallas Cowboys | 24 | 21 | box |
| 12 | Sun | December 4, 2005 | L | Denver Broncos | @ | Kansas City Chiefs | 27 | 31 | box |
| 13 | Sun | December 11, 2005 | W | Denver Broncos | Baltimore Ravens | 12 | 10 | box | |
| 14 | Sat | December 17, 2005 | W | Denver Broncos | @ | Buffalo Bills | 28 | 17 | box |
| 15 | Sat | December 24, 2005 | W | Denver Broncos | Oakland Raiders | 22 | 3 | box | |
| 16 | Sat | December 31, 2005 | W | Denver Broncos | @ | San Diego Chargers | 23 | 7 | box |
| 17 | Sat | January 14, 2006 | W | Denver Broncos | New England Patriots | 27 | 13 | box | |
| 18 | Sun | January 22, 2006 | L | Denver Broncos | Pittsburgh Steelers | 17 | 34 | box |