| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Sun | September 7, 2008 | L | Houston Texans | @ | Pittsburgh Steelers | 17 | 38 | box |
| 2 | Sun | September 21, 2008 | L | Houston Texans | @ | Tennessee Titans | 12 | 31 | box |
| 3 | Sun | September 28, 2008 | L | Houston Texans | @ | Jacksonville Jaguars | 27 | 30 | box |
| 4 | Sun | October 12, 2008 | W | Houston Texans | Miami Dolphins | 29 | 28 | box | |
| 5 | Sun | October 19, 2008 | W | Houston Texans | Detroit Lions | 28 | 21 | box | |
| 6 | Sun | October 26, 2008 | W | Houston Texans | Cincinnati Bengals | 35 | 6 | box | |
| 7 | Sun | November 2, 2008 | L | Houston Texans | @ | Minnesota Vikings | 21 | 28 | box |
| 8 | Sun | December 7, 2008 | W | Houston Texans | @ | Green Bay Packers | 24 | 21 | box |
| 9 | Sun | December 14, 2008 | W | Houston Texans | Tennessee Titans | 13 | 12 | box | |
| 10 | Sun | December 21, 2008 | L | Houston Texans | @ | Oakland Raiders | 16 | 27 | box |
| 11 | Sun | December 28, 2008 | W | Houston Texans | Chicago Bears | 31 | 24 | box |