| Rk | Day | Date | Tm | Opp | Tm | Opp | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Mon | September 8, 1980 | W | Dallas Cowboys | @ | Washington Redskins | 17 | 3 | box |
| 2 | Sun | September 14, 1980 | L | Dallas Cowboys | @ | Denver Broncos | 20 | 41 | box |
| 3 | Sun | September 21, 1980 | W | Dallas Cowboys | Tampa Bay Buccaneers | 28 | 17 | box | |
| 4 | Sun | September 28, 1980 | W | Dallas Cowboys | @ | Green Bay Packers | 28 | 7 | box |
| 5 | Sun | October 5, 1980 | W | Dallas Cowboys | New York Giants | 24 | 3 | box | |
| 6 | Sun | October 12, 1980 | W | Dallas Cowboys | San Francisco 49ers | 59 | 14 | box | |
| 7 | Sun | October 19, 1980 | L | Dallas Cowboys | @ | Philadelphia Eagles | 10 | 17 | box |
| 8 | Sun | October 26, 1980 | W | Dallas Cowboys | San Diego Chargers | 42 | 31 | box | |
| 9 | Sun | November 2, 1980 | W | Dallas Cowboys | @ | St. Louis Cardinals | 27 | 24 | box |
| 10 | Sun | November 9, 1980 | L | Dallas Cowboys | @ | New York Giants | 35 | 38 | box |
| 11 | Sun | November 16, 1980 | W | Dallas Cowboys | St. Louis Cardinals | 31 | 21 | box | |
| 12 | Sun | November 23, 1980 | W | Dallas Cowboys | Washington Redskins | 14 | 10 | box | |
| 13 | Thu | November 27, 1980 | W | Dallas Cowboys | Seattle Seahawks | 51 | 7 | box | |
| 14 | Sun | December 7, 1980 | W | Dallas Cowboys | @ | Oakland Raiders | 19 | 13 | box |
| 15 | Mon | December 15, 1980 | L | Dallas Cowboys | @ | Los Angeles Rams | 14 | 38 | box |
| 16 | Sun | December 21, 1980 | W | Dallas Cowboys | Philadelphia Eagles | 35 | 27 | box | |
| 17 | Sun | December 28, 1980 | W | Dallas Cowboys | Los Angeles Rams | 34 | 13 | box | |
| 18 | Sun | January 4, 1981 | W | Dallas Cowboys | @ | Atlanta Falcons | 30 | 27 | box |
| 19 | Sun | January 11, 1981 | L | Dallas Cowboys | @ | Philadelphia Eagles | 7 | 20 | box |