| Rank | Player (age), + - HOFer, Bold - Active | TD | Years | Teams |
|---|---|---|---|---|
| 1. | LaDainian Tomlinson (29) | 144 | 2001-2009 | sdg |
| 2. | Terrell Owens (35) | 143 | 1996-2009 | 4TM |
| 3. | Randy Moss (31) | 140 | 1998-2009 | 3TM |
| 4. | Isaac Bruce (36) | 91 | 1994-2009 | 2TM |
| Edgerrin James (30) | 91 | 1999-2009 | 3TM | |
| 6. | Tony Gonzalez (32) | 79 | 1997-2009 | 2TM |
| 7. | Clinton Portis (27) | 78 | 2002-2009 | 2TM |
| 8. | Hines Ward (32) | 75 | 1998-2009 | pit |
| 9. | Torry Holt (32) | 74 | 1999-2009 | 2TM |
| 10. | Ahman Green (31) | 73 | 1998-2009 | 3TM |
| 11. | Fred Taylor (32) | 72 | 1998-2009 | 2TM |
| 12. | Brian Westbrook (29) | 68 | 2002-2009 | phi |
| 13. | Ricky Williams (31) | 62 | 1999-2009 | 2TM |
| Jamal Lewis (29) | 62 | 2000-2009 | 2TM | |
| 15. | Larry Johnson (29) | 61 | 2003-2009 | kan |
| Muhsin Muhammad (35) | 61 | 1996-2009 | 2TM | |
| 17. | Derrick Mason (34) | 59 | 1997-2009 | 2TM |
| Reggie Wayne (30) | 59 | 2001-2009 | clt | |
| 19. | Chad Ochocinco (30) | 58 | 2001-2009 | cin |
| Thomas Jones (30) | 58 | 2000-2009 | 4TM | |
| 21. | Antonio Gates (28) | 53 | 2003-2009 | sdg |
| Chris Chambers (30) | 53 | 2001-2009 | 2TM | |
| 23. | Steve Smith (29) | 52 | 2001-2009 | car |
| 24. | Larry Fitzgerald (25) | 51 | 2004-2009 | crd |
| 25. | Maurice Jones-Drew (23) | 50 | 2006-2009 | jax |
| 26. | Santana Moss (29) | 48 | 2001-2009 | 2TM |
| 27. | Donald Driver (33) | 47 | 1999-2009 | gnb |
| Laveranues Coles (31) | 47 | 2000-2009 | 3TM | |
| 29. | Marion Barber (25) | 46 | 2005-2009 | dal |
| Willis McGahee (27) | 46 | 2004-2009 | 2TM | |
| 31. | Steven Jackson (25) | 45 | 2004-2009 | ram |
| 32. | Anquan Boldin (28) | 41 | 2003-2009 | crd |
| 33. | T.J. Houshmandzadeh (31) | 40 | 2001-2009 | 2TM |
| 34. | Brandon Jacobs (26) | 39 | 2005-2009 | nyg |
| 35. | Andre Johnson (27) | 37 | 2003-2009 | htx |
| Bobby Engram (35) | 37 | 1996-2009 | 3TM | |
| 37. | Marty Booker (32) | 36 | 1999-2009 | 3TM |
| Alge Crumpler (31) | 36 | 2001-2009 | 2TM | |
| 39. | Joseph Addai (25) | 35 | 2006-2009 | clt |
| Lee Evans (27) | 35 | 2004-2009 | buf | |
| 41. | Daunte Culpepper (31) | 34 | 1999-2009 | 4TM |
| Dallas Clark (29) | 34 | 2003-2009 | clt | |
| 43. | Roy E. Williams (27) | 32 | 2004-2009 | 2TM |
| DeAngelo Williams (25) | 32 | 2006-2009 | car | |
| Javon Walker (30) | 32 | 2002-2009 | 3TM | |
| Brandon Stokley (32) | 32 | 1999-2009 | 3TM | |
| Adrian Peterson (23) | 32 | 2007-2009 | min | |
| Todd Heap (28) | 32 | 2001-2009 | rav | |
| Ronnie Brown (27) | 32 | 2005-2009 | mia | |
| 50. | Nate Burleson (27) | 31 | 2003-2009 | 2TM |
| Kevin Faulk (32) | 31 | 1999-2009 | nwe | |
| Frank Gore (25) | 31 | 2005-2009 | sfo | |
| LaMont Jordan (30) | 31 | 2001-2009 | 4TM | |
| Michael Turner (26) | 31 | 2004-2009 | 2TM |