| Rank | Player (age), + - HOFer, Bold - Active | Att | Years | Teams |
|---|---|---|---|---|
| 1. | Brett Favre (38) | 8,758 | 1991-2007 | 2TM |
| 2. | Vinny Testaverde (44) | 6,701 | 1987-2007 | 7TM |
| 3. | Peyton Manning (31) | 5,405 | 1998-2007 | clt |
| 4. | Kerry Collins (35) | 5,254 | 1995-2007 | 5TM |
| 5. | Steve McNair (34) | 4,544 | 1995-2007 | 2TM |
| 6. | Brad Johnson (39) | 4,248 | 1994-2007 | 4TM |
| 7. | Jon Kitna (35) | 3,994 | 1997-2007 | 3TM |
| 8. | Donovan McNabb (31) | 3,732 | 1999-2007 | phi |
| 9. | Trent Green (37) | 3,668 | 1997-2007 | 4TM |
| 10. | Tom Brady (30) | 3,642 | 2000-2007 | nwe |
| 11. | Jeff Garcia (37) | 3,300 | 1999-2007 | 5TM |
| 12. | Trent Dilfer (35) | 3,172 | 1994-2007 | 5TM |
| 13. | Matt Hasselbeck (32) | 3,138 | 1999-2007 | 2TM |
| 14. | Drew Brees (28) | 3,015 | 2001-2007 | 2TM |
| 15. | Kurt Warner (36) | 2,959 | 1998-2007 | 3TM |
| 16. | Daunte Culpepper (30) | 2,927 | 1999-2007 | 3TM |
| 17. | Gus Frerotte (36) | 2,805 | 1994-2007 | 7TM |
| 18. | Brian Griese (32) | 2,612 | 1998-2007 | 4TM |
| 19. | Joey Harrington (29) | 2,538 | 2002-2007 | 3TM |
| 20. | Marc Bulger (30) | 2,484 | 2002-2007 | ram |
| 21. | David Carr (28) | 2,206 | 2002-2007 | 2TM |
| 22. | Carson Palmer (28) | 2,036 | 2004-2007 | cin |
| 23. | Jake Delhomme (32) | 2,020 | 1999-2007 | 2TM |
| 24. | Chad Pennington (31) | 1,919 | 2000-2007 | nyj |
| 25. | Eli Manning (26) | 1,805 | 2004-2007 | nyg |
| 26. | Charlie Batch (33) | 1,459 | 1998-2007 | 2TM |
| 27. | Ben Roethlisberger (25) | 1,436 | 2004-2007 | pit |
| 28. | Byron Leftwich (27) | 1,402 | 2003-2007 | 2TM |
| 29. | Kyle Boller (26) | 1,311 | 2003-2007 | rav |
| 30. | Josh McCown (28) | 1,052 | 2002-2007 | 3TM |
| 31. | Philip Rivers (26) | 950 | 2004-2007 | sdg |
| 32. | Patrick Ramsey (28) | 910 | 2002-2007 | 3TM |
| 33. | Rex Grossman (27) | 900 | 2003-2007 | chi |
| 34. | Kelly Holcomb (34) | 893 | 1997-2007 | 4TM |
| 35. | Damon Huard (34) | 865 | 1998-2007 | 3TM |
| 36. | David Garrard (29) | 864 | 2002-2007 | jax |
| 37. | Tony Romo (27) | 857 | 2004-2007 | dal |
| 38. | J.P. Losman (26) | 837 | 2004-2007 | buf |
| 39. | Alex Smith (23) | 800 | 2005-2007 | sfo |
| 40. | Vince Young (24) | 739 | 2006-2007 | oti |
| 41. | Tim Rattay (30) | 714 | 2000-2007 | 3TM |
| 42. | Chris Weinke (35) | 709 | 2001-2007 | 2TM |
| 43. | A.J. Feeley (30) | 665 | 2001-2007 | 2TM |
| 44. | Todd Collins (36) | 651 | 1995-2007 | 3TM |
| 45. | Derek Anderson (24) | 644 | 2006-2007 | cle |
| 46. | Jason Campbell (26) | 624 | 2006-2007 | was |
| 47. | Anthony Wright (31) | 605 | 2000-2007 | 4TM |
| 48. | Jay Cutler (24) | 604 | 2006-2007 | den |
| 49. | Charlie Frye (26) | 566 | 2005-2007 | 2TM |
| 50. | Jamie Martin (37) | 541 | 1996-2007 | 3TM |